From X-inactivation to neurodevelopment: CHD8-transcription factors (TFs) competitive binding at regulatory regions of CHD8 target genes can contribute to correct neuronal differentiation.
Chromatin remodeler
Chromodomain helicase DNA-Binding protein 8 (CHD8)
Competitive binding
Dosage sensitive gene regulation
Long non-coding RNA
Non-linear gene regulation
Sex bias
Transcription factors (TFs)
X-inactive specific transcript (Xist)
Yin Yang 1 (YY1)
Journal
Current research in neurobiology
ISSN: 2665-945X
Titre abrégé: Curr Res Neurobiol
Pays: Netherlands
ID NLM: 101778135
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
04
2023
revised:
19
09
2023
accepted:
15
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
The chromodomain helicase DNA-binding protein 8 (CHD8) is a chromatin remodeler whose mutation is associated, with high penetrance, with autism. Individuals with
Identifiants
pubmed: 38020809
doi: 10.1016/j.crneur.2023.100114
pii: S2665-945X(23)00042-6
pmc: PMC10663126
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100114Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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