Dual function of angiogenin-4 inducing intestinal stem cells and apoptosis.
Wnt signalling
antimicrobial peptide (AMP)
cell differentiation
intestinal epithelium
stem cells
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
03
2023
accepted:
17
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
The intestinal epithelium is the first line of host defense, and its homeostasis is dependent on soluble factors that comprise the crypt niche. Antimicrobial proteins are one of the mediators to maintain gut homeostasis. Angiogenin-4 (Ang4) is a member of the ribonuclease A superfamily and plays a pivotal role in antimicrobial activity against gut microbiota. However, the functions of Ang4 within the intestinal crypt niche, particularly its involvement in the development of intestinal epithelial cells (IECs), remain unknown. Here, we demonstrate that Ang4 plays a significant role in maintaining Lgr5
Identifiants
pubmed: 38020881
doi: 10.3389/fcell.2023.1181145
pii: 1181145
pmc: PMC10651741
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1181145Informations de copyright
Copyright © 2023 Abo, Sultana and Kawashima.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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