Optimized peptide nanofibrils as efficient transduction enhancers for
CAR-NK cells
CAR-T cells
gene delivery
lentiviral vector
peptide nanofibrils
retroviral vector
transduction enhancer
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
07
2023
accepted:
24
10
2023
medline:
1
12
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Chimeric antigen receptor (CAR)-T cell therapy is a groundbreaking immunotherapy for cancer. However, the intricate and costly manufacturing process remains a hurdle. Improving the transduction rate is a potential avenue to cut down costs and boost therapeutic efficiency. Peptide nanofibrils (PNFs) serve as one such class of transduction enhancers. PNFs bind to negatively charged virions, facilitating their active engagement by cellular protrusions, which enhances virion attachment to cells, leading to increased cellular entry and gene transfer rates. While first-generation PNFs had issues with aggregate formation and potential immunogenicity, our study utilized
Identifiants
pubmed: 38022685
doi: 10.3389/fimmu.2023.1270243
pmc: PMC10666768
doi:
Substances chimiques
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1270243Informations de copyright
Copyright © 2023 Rauch-Wirth, Renner, Kaygisiz, Weil, Zimmermann, Rodriguez-Alfonso, Schütz, Wiese, Ständker, Weil, Schmiedel and Münch.
Déclaration de conflit d'intérêts
JM is inventor on patents that claim to use peptide nanofibrils as transduction enhancer. JM, DS, LR-W, KK and TW filed additional patents to use peptides as transduction enhancer. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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