Comprehensive bioinformatics analysis revealed potential key genes and pathways underlying abdominal aortic aneurysm.
Abdominal aortic aneurysm
Comprehensive bioinformatics analysis
Key genes
RNA-seq analysis
ScRNA-seq analysis
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
07
2023
revised:
30
10
2023
accepted:
30
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Abdominal aortic aneurysm (AAA) is a permanent, asymptomatic segmental dilatation of the abdominal aorta, with a high mortality risk upon rupture. Identification of potential key genes and pathways may help to develop curative drugs for AAA. We conducted RNA-seq on abdominal aortic tissues from both AAA patients and normal individuals as a control group. Integrated bioinformatic analysis was subsequently performed to comprehensively reveal potential key genes and pathways. A total of 1148 differential expressed genes (DEGs) (631 up-regulated and 517 down-regulated) were identified in our study. Gene Ontology (GO) analysis revealed enrichment in terms related to extracellular matrix organization, while KEGG analysis indicated enrichment in hematopoietic cell lineage and ECM-receptor interaction. Protein-protein interaction (PPI) network analysis revealed several candidate key genes, and differential expression of 6 key genes (
Identifiants
pubmed: 38022704
doi: 10.1016/j.csbj.2023.10.052
pii: S2001-0370(23)00409-9
pmc: PMC10665597
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5423-5433Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that there are no commercial or financial relationships that could be perceived as a potential conflict of interest in relation to this research.
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