Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration.

Carbon tetrachloride Forkhead box A Liver regeneration Partial hepatectomy Proliferation

Journal

JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 18 12 2022
revised: 07 08 2023
accepted: 24 08 2023
medline: 29 11 2023
pubmed: 29 11 2023
entrez: 29 11 2023
Statut: epublish

Résumé

Liver regeneration is vital for the recovery of liver function after injury, yet the underlying mechanism remains to be elucidated. Forkhead box protein A3 (FOXA3), a member of the forkhead box family, plays important roles in endoplasmic reticulum stress sensing, and lipid and glucose homoeostasis, yet its functions in liver regeneration are unknown. Here, we explored whether Foxa3 regulates liver regeneration via acute and chronic liver injury mice models. We further characterised the molecular mechanism by chromatin immunoprecipitation sequencing and rescue experiments Foxa3 is dominantly expressed in hepatocytes and cholangiocytes and is induced upon partial hepatectomy (PH) or carbon tetrachloride (CCl These data characterise Foxa3 as a vital regulator of liver regeneration, which may represent an essential factor to maintain liver mass after liver injury by governing Cebpb transcription. Liver regeneration is vital for the recovery of liver function after chemical insults or hepatectomy, yet the underlying mechanism remains to be elucidated. Herein, via

Sections du résumé

Background & Aims UNASSIGNED
Liver regeneration is vital for the recovery of liver function after injury, yet the underlying mechanism remains to be elucidated. Forkhead box protein A3 (FOXA3), a member of the forkhead box family, plays important roles in endoplasmic reticulum stress sensing, and lipid and glucose homoeostasis, yet its functions in liver regeneration are unknown.
Methods UNASSIGNED
Here, we explored whether Foxa3 regulates liver regeneration via acute and chronic liver injury mice models. We further characterised the molecular mechanism by chromatin immunoprecipitation sequencing and rescue experiments
Results UNASSIGNED
Foxa3 is dominantly expressed in hepatocytes and cholangiocytes and is induced upon partial hepatectomy (PH) or carbon tetrachloride (CCl
Conclusions UNASSIGNED
These data characterise Foxa3 as a vital regulator of liver regeneration, which may represent an essential factor to maintain liver mass after liver injury by governing Cebpb transcription.
Impact and Implications UNASSIGNED
Liver regeneration is vital for the recovery of liver function after chemical insults or hepatectomy, yet the underlying mechanism remains to be elucidated. Herein, via

Identifiants

DOI: 10.1016/j.jhepr.2023.100906 PMID: 38023606 PMC: PMC10679869
pubmed: 38023606
doi: 10.1016/j.jhepr.2023.100906
pii: S2589-5559(23)00237-9
pmc: PMC10679869
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100906

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests. Please refer to the accompanying ICMJE disclosure forms for further details.

Références

Science. 2021 Feb 26;371(6532):
pubmed: 33632817
Signal Transduct Target Ther. 2020 Dec 26;5(1):296
pubmed: 33361765
Nat Protoc. 2008;3(7):1167-70
pubmed: 18600221
Nat Rev Gastroenterol Hepatol. 2016 Aug;13(8):473-85
pubmed: 27353402
J Biol Chem. 2001 Nov 16;276(46):42812-7
pubmed: 11546810
Cell Mol Life Sci. 2006 Oct;63(19-20):2317-28
pubmed: 16909212
Genes Dev. 2020 Aug 1;34(15-16):1039-1050
pubmed: 32561546
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3377-82
pubmed: 26957608
Hepatology. 2013 Dec;58(6):2089-98
pubmed: 23744762
Gastroenterology. 2005 Jan;128(1):33-42
pubmed: 15633121
Hepatology. 2012 Dec;56(6):2142-53
pubmed: 22467277
Redox Biol. 2017 Apr;11:622-630
pubmed: 28126520
J Clin Invest. 1998 Sep 1;102(5):996-1007
pubmed: 9727068
Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1574-1587
pubmed: 31291759
Front Cell Dev Biol. 2022 May 05;10:903740
pubmed: 35721478
J Hepatol. 2004 Dec;41(6):983-91
pubmed: 15582132
Oncogene. 2015 Oct 29;34(44):5524-35
pubmed: 25684142
Biochem Biophys Res Commun. 2010 Jul 2;397(3):453-8
pubmed: 20510877
Transplantation. 2023 Apr 1;107(4):878-889
pubmed: 36413144
J Hepatol. 2013 Dec;59(6):1239-45
pubmed: 23872603
Cell Res. 2019 Feb;29(2):124-135
pubmed: 30560924
Hepatology. 1998 Sep;28(3):738-43
pubmed: 9731566
Science. 2000 Feb 18;287(5456):1253-8
pubmed: 10678830
Gastroenterology. 2014 Feb;146(2):349-56
pubmed: 24315991
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):40-55
pubmed: 32764740
Eur J Pharmacol. 2017 Nov 15;815:446-453
pubmed: 28966130
Biochem Biophys Res Commun. 2005 Apr 1;329(1):182-7
pubmed: 15721291
Gut. 2022 Nov;71(11):2325-2336
pubmed: 34996824
Am J Pathol. 2010 Jan;176(1):2-13
pubmed: 20019184
Nat Methods. 2019 Dec;16(12):1289-1296
pubmed: 31740819
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
Antioxidants (Basel). 2021 May 27;10(6):
pubmed: 34072123
Sci Rep. 2017 Nov 30;7(1):16675
pubmed: 29192290
Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14289-94
pubmed: 25225406
Hepatology. 2016 Oct;64(4):1388-9
pubmed: 27038241
Genomics. 1994 Apr;20(3):377-85
pubmed: 8034310
Nat Rev Gastroenterol Hepatol. 2020 Dec;17(12):755-772
pubmed: 32681074
Mol Cell Biol. 2013 Sep;33(17):3392-9
pubmed: 23798556
Front Pharmacol. 2020 Nov 13;11:601716
pubmed: 33364966
Nature. 2017 Jul 20;547(7663):350-354
pubmed: 28700576
Nat Rev Cancer. 2017 Jan 27;17(2):93-115
pubmed: 28127048
Hepatology. 2020 Apr;71(4):1421-1436
pubmed: 31469186
J Hepatol. 2021 Jul;75(1):150-162
pubmed: 33548387
Hepatology. 2004 Dec;40(6):1322-32
pubmed: 15565660
Mol Cell Biol. 1998 Jul;18(7):4245-51
pubmed: 9632808
Cell Res. 2017 May;27(5):642-656
pubmed: 28303890
Mol Endocrinol. 2010 May;24(5):886-97
pubmed: 20211986
J Hepatol. 2005 Aug;43(2):294-302
pubmed: 15922473
Hepatology. 2017 Apr;65(4):1384-1392
pubmed: 27997988
Gastroenterology. 2022 Aug;163(2):481-494
pubmed: 35489428
Gastroenterology. 2006 Nov;131(5):1561-72
pubmed: 17101329
Genes Dev. 2015 May 1;29(9):904-9
pubmed: 25934503
Cell Stem Cell. 2016 Jun 2;18(6):797-808
pubmed: 26923201
Nutrients. 2020 Jun 12;12(6):
pubmed: 32545423
Mol Cell. 2019 Aug 8;75(3):644-660.e5
pubmed: 31398325
Nat Cell Biol. 2015 Aug;17(8):971-983
pubmed: 26192438
Cancer Res. 2008 Dec 15;68(24):10154-62
pubmed: 19074882
J Hepatol. 2022 Aug;77(2):436-452
pubmed: 35276271
Nat Genet. 2000 Jul;25(3):254-5
pubmed: 10888866
Nature. 2005 Jun 16;435(7044):944-7
pubmed: 15959514
J Cardiovasc Pharmacol. 2001 May;37(5):596-606
pubmed: 11336110
Cell Death Differ. 2017 Jan;24(1):8-14
pubmed: 27768121
Hepatology. 2021 Dec;74(6):3345-3361
pubmed: 34320243
EMBO Mol Med. 2021 Apr 9;13(4):e13162
pubmed: 33751828
Cell Death Discov. 2020 Nov 1;6(1):116
pubmed: 33298860

Auteurs

Guoqiang Li (G)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Lijun Zhu (L)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Mingwei Guo (M)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Dongmei Wang (D)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Meiyao Meng (M)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Yinzhao Zhong (Y)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Zhijian Zhang (Z)

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai, China.

Yi Lin (Y)

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai, China.

Caizhi Liu (C)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jiawen Wang (J)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Yahui Zhang (Y)

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai, China.

Yining Gao (Y)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Yuxiang Cao (Y)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Zhirui Xia (Z)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Jin Qiu (J)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Yu Li (Y)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Shuang Liu (S)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Haibing Chen (H)

Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Wenyue Liu (W)

Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Yu Han (Y)

Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Minghua Zheng (M)

MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.

Xinran Ma (X)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China.
Chongqing Key Laboratory of Precision Optics, Chongqing Institute of East China Normal University, Chongqing, China.

Lingyan Xu (L)

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Classifications MeSH