Triglyceride-Glucose Index and Cardiovascular Events in Kidney Transplant Recipients.
cardiovascular disease
kidney transplantation
metabolic syndrome
triglyceride glucose index
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
27
03
2023
revised:
20
07
2023
accepted:
16
08
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact of insulin resistance on CV risk after transplantation is not well defined. We tested whether triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, may predict posttransplant CVEs in a cohort of 715 consecutive KTRs all included 1 year after transplant. Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion was 4.75 ± 0.29 (median, 4.73 [4.14-5.84]). In multiple regression analysis, having a TyG above the median value was associated with higher body mass index (BMI), low high-density lipoprotein (HDL) cholesterol level, and greater urinary protein excretion. A total of 127 CVEs (17.7%) occurred during the study period. In univariate analysis, TyG was strongly associated with CVE occurrence (hazard ratio [HR] 2.06, 95% CI 1.42-3.50, for each increase of 0.1 in TyG, Insulin resistance, as measured by the TyG index is strongly associated with CVE in KTRs. Improving insulin sensitivity seems to be a major issue to prevent CV morbidity and mortality in this high-risk population.
Identifiants
pubmed: 38025208
doi: 10.1016/j.ekir.2023.08.021
pii: S2468-0249(23)01455-9
pmc: PMC10658270
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2307-2314Informations de copyright
© 2023 International Society of Nephrology. Published by Elsevier Inc.
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