Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD.
biomarkers
cardiovascular outcomes
cohort
eGFR
suPAR
uACR
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
04
08
2023
accepted:
28
08
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Soluble urokinase plasminogen activation receptor (suPAR) is an immune-derived pathogenic factor for kidney and atherosclerotic disease. Whether the association between suPAR and cardiovascular (CV) outcomes is dependent on the severity of underlying kidney disease is unclear. We measured serum suPAR levels in 4994 participants (mean age 60 years; 60% men; 36% with diabetes mellitus; mean estimated glomerular filtration rate (eGFR) 49 ml/min per 1.73 m The median suPAR level was 1771 pg/ml (interquartile range [IQR] 1447-2254 pg/ml). SuPAR levels were positively and independently correlated with age, eGFR, UACR, and parathyroid hormone levels. There were 573 deaths, including 190 CV deaths and 683 MACE events at a follow-up time of 6.5 years. In multivariable analyses, suPAR levels (log In a large cohort of individuals with chronic kidney disease (CKD), suPAR levels were associated with mortality and CV outcomes independently of indices of kidney function, consistent with its independent role in the pathogenesis of atherosclerosis.
Identifiants
pubmed: 38025216
doi: 10.1016/j.ekir.2023.08.038
pii: S2468-0249(23)01475-4
pmc: PMC10658273
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2265-2275Investigateurs
Kai-Uwe Eckardt
(KU)
Heike Meiselbach
(H)
Markus P Schneider
(MP)
Mario Schiffer
(M)
Hans-Ulrich Prokosch
(HU)
Barbara Bärthlein
(B)
Andreas Beck
(A)
Detlef Kraska
(D)
André Reis
(A)
Arif B Ekici
(AB)
Susanne Becker
(S)
Ulrike Alberth-Schmidt
(U)
Sabine Marschall
(S)
Eugenia Schefler
(E)
Anke Weigel
(A)
Gerd Walz
(G)
Anna Köttgen
(A)
Ulla T Schultheiß
(UT)
Fruzsina Kotsis
(F)
Simone Meder
(S)
Erna Mitsch
(E)
Ursula Reinhard
(U)
Jürgen Floege
(J)
Turgay Saritas
(T)
Elke Schaeffner
(E)
Seema Baid-Agrawal
(S)
Kerstin Theisen
(K)
Kai Schmidt-Ott
(K)
Martin Zeier
(M)
Claudia Sommerer
(C)
Mehtap Aykac
(M)
Gunter Wolf
(G)
Martin Busch
(M)
Rainer Paul
(R)
Thomas Sitter
(T)
Christoph Wanner
(C)
Vera Krane
(V)
Antje Börner-Klein
(A)
Britta Bauer
(B)
Florian Kronenberg
(F)
Julia Raschenberger
(J)
Barbara Kollerits
(B)
Lukas Forer
(L)
Sebastian Schönherr
(S)
Hansi Weissensteiner
(H)
Peter Oefner
(P)
Wolfram Gronwald
(W)
Matthias Schmid
(M)
Jennifer Nadal
(J)
Informations de copyright
© 2023 International Society of Nephrology. Published by Elsevier Inc.
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