Brain Representation of Animal and Non-Animal Images in Patients with Mild Cognitive Impairment and Alzheimer's Disease.
Alzheimer’s disease
functional MRI
high-level visual categorization
mild cognitive impairment
multivariate pattern analysis
Journal
Journal of Alzheimer's disease reports
ISSN: 2542-4823
Titre abrégé: J Alzheimers Dis Rep
Pays: Netherlands
ID NLM: 101705500
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
02
2023
accepted:
06
09
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
In early Alzheimer's disease (AD), high-level visual functions and processing speed are impacted. Few functional magnetic resonance imaging (fMRI) studies have investigated high-level visual deficits in AD, yet none have explored brain activity patterns during rapid animal/non-animal categorization tasks. To address this, we utilized the previously known Integrated Cognitive Assessment (ICA) to collect fMRI data and compare healthy controls (HC) to individuals with mild cognitive impairment (MCI) and mild AD. The ICA encompasses a rapid visual categorization task that involves distinguishing between animals and non-animals within natural scenes. To comprehensively explore variations in brain activity levels and patterns, we conducted both univariate and multivariate analyses of fMRI data. The ICA task elicited activation across a range of brain regions, encompassing the temporal, parietal, occipital, and frontal lobes. Univariate analysis, which compared responses to animal versus non-animal stimuli, showed no significant differences in the regions of interest (ROIs) across all groups, with the exception of the left anterior supramarginal gyrus in the HC group. In contrast, multivariate analysis revealed that in both HC and MCI groups, several regions could differentiate between animals and non-animals based on distinct patterns of activity. Notably, such differentiation was absent within the mild AD group. Our study highlights the ICA task's potential as a valuable cognitive assessment tool designed for MCI and AD. Additionally, our use of fMRI pattern analysis provides valuable insights into the complex changes in brain function associated with AD. This approach holds promise for enhancing our understanding of the disease's progression.
Sections du résumé
Background
UNASSIGNED
In early Alzheimer's disease (AD), high-level visual functions and processing speed are impacted. Few functional magnetic resonance imaging (fMRI) studies have investigated high-level visual deficits in AD, yet none have explored brain activity patterns during rapid animal/non-animal categorization tasks.
Objective
UNASSIGNED
To address this, we utilized the previously known Integrated Cognitive Assessment (ICA) to collect fMRI data and compare healthy controls (HC) to individuals with mild cognitive impairment (MCI) and mild AD.
Methods
UNASSIGNED
The ICA encompasses a rapid visual categorization task that involves distinguishing between animals and non-animals within natural scenes. To comprehensively explore variations in brain activity levels and patterns, we conducted both univariate and multivariate analyses of fMRI data.
Results
UNASSIGNED
The ICA task elicited activation across a range of brain regions, encompassing the temporal, parietal, occipital, and frontal lobes. Univariate analysis, which compared responses to animal versus non-animal stimuli, showed no significant differences in the regions of interest (ROIs) across all groups, with the exception of the left anterior supramarginal gyrus in the HC group. In contrast, multivariate analysis revealed that in both HC and MCI groups, several regions could differentiate between animals and non-animals based on distinct patterns of activity. Notably, such differentiation was absent within the mild AD group.
Conclusions
UNASSIGNED
Our study highlights the ICA task's potential as a valuable cognitive assessment tool designed for MCI and AD. Additionally, our use of fMRI pattern analysis provides valuable insights into the complex changes in brain function associated with AD. This approach holds promise for enhancing our understanding of the disease's progression.
Identifiants
pubmed: 38025804
doi: 10.3233/ADR-230132
pii: ADR230132
pmc: PMC10657719
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1133-1152Informations de copyright
© 2023 – The authors. Published by IOS Press.
Déclaration de conflit d'intérêts
SKR and CK are shareholders of Cognetivity ltd. MHM was Cognetivity’s employee. Other authors declared no conflict of interest.
Références
Neurology. 2000 Dec 12;55(11):1613-20
pubmed: 11113213
Nat Neurosci. 2005 May;8(5):679-85
pubmed: 15852014
Int J Geriatr Psychiatry. 2006 Nov;21(11):1078-85
pubmed: 16977673
J Alzheimers Dis. 2014;39(1):181-9
pubmed: 24121969
J Psychiatr Res. 1982-1983;17(1):37-49
pubmed: 7183759
Nat Neurosci. 2009 May;12(5):535-40
pubmed: 19396166
Int Psychogeriatr. 2012 Feb;24(2):223-30
pubmed: 21995955
Brain Struct Funct. 2010 Jun;214(5-6):655-67
pubmed: 20512370
Nat Rev Neurosci. 2014 Aug;15(8):536-48
pubmed: 24962370
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Nat Rev Neurol. 2019 Jan;15(1):11-24
pubmed: 30532084
Biol Psychiatry. 2014 Apr 1;75(7):565-73
pubmed: 24629669
AJNR Am J Neuroradiol. 2000 Nov-Dec;21(10):1869-75
pubmed: 11110539
Nat Neurosci. 2005 May;8(5):686-91
pubmed: 15852013
Brain. 2007 Jul;130(Pt 7):1745-58
pubmed: 17566054
Neuroimage. 2003 Jun;19(2 Pt 1):261-70
pubmed: 12814577
Neurocase. 2005 Feb;11(1):80-4
pubmed: 15804928
Alzheimers Dement. 2015 Jan;11(1):70-98
pubmed: 25022540
Neuropsychologia. 2004;42(3):335-45
pubmed: 14670572
Neuropsychologia. 2008 Apr;46(5):1193-200
pubmed: 18067929
Cereb Cortex. 1994 Mar-Apr;4(2):138-50
pubmed: 8038565
J Alzheimers Dis. 2010;21(1):15-34
pubmed: 20182034
Neurology. 1990 Mar;40(3 Pt 1):439-43
pubmed: 2314585
J Alzheimers Dis. 2016;51(1):263-75
pubmed: 26836171
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
J Cogn Neurosci. 2018 Nov;30(11):1559-1576
pubmed: 29877767
J Alzheimers Dis Rep. 2021 Jul 08;5(1):549-562
pubmed: 34514338
Brain. 2005 Apr;128(Pt 4):773-87
pubmed: 15705615
Front Psychiatry. 2021 Jul 22;12:706695
pubmed: 34366938
Neuron. 2009 Apr 16;62(1):42-52
pubmed: 19376066
Brain. 2006 Jul;129(Pt 7):1780-8
pubmed: 16670180
Front Integr Neurosci. 2014 Jul 25;8:60
pubmed: 25120440
Neurobiol Aging. 2012 Aug;33(8):1564-78
pubmed: 21813210
Ann N Y Acad Sci. 2007 Feb;1097:146-55
pubmed: 17413017
J Geriatr Psychiatry Neurol. 2017 Jul;30(4):220-227
pubmed: 28639877
Alzheimers Res Ther. 2012 Jan 10;4(1):2
pubmed: 22236691
Neuron. 2008 Dec 26;60(6):1126-41
pubmed: 19109916
Dement Geriatr Cogn Disord. 2009;28(4):343-7
pubmed: 19864908
J Clin Exp Neuropsychol. 2004 Feb;26(1):11-23
pubmed: 14972690
J Neurosci. 1987 Jun;7(6):1799-808
pubmed: 2439665
Arch Neurol. 1985 Jul;42(7):667-71
pubmed: 4015463
Age Ageing. 1996 Mar;25(2):113-20
pubmed: 8670538
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
PLoS One. 2022 Feb 23;17(2):e0264058
pubmed: 35196356
Neurology. 1994 Dec;44(12):2308-14
pubmed: 7991117
Science. 2001 Sep 28;293(5539):2425-30
pubmed: 11577229
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Annu Rev Psychol. 1995;46:329-53
pubmed: 7872732
Alzheimers Res Ther. 2012 Mar 15;4(2):8
pubmed: 22423634
Psychol Rev. 1996 Jul;103(3):403-28
pubmed: 8759042
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1829-1838
pubmed: 33313639
Biol Psychol. 2000 Oct;54(1-3):35-54
pubmed: 11035219
Brain. 2010 May;133(Pt 5):1352-67
pubmed: 20410145
Nebr Symp Motiv. 1991;39:1-37
pubmed: 1843133
Sci Rep. 2019 Jan 31;9(1):1102
pubmed: 30705371
Neurol Clin. 2003 Aug;21(3):709-28
pubmed: 13677819
J Neurol Neurosurg Psychiatry. 2003 Jan;74(1):44-50
pubmed: 12486265
Brain. 2006 May;129(Pt 5):1113-24
pubmed: 16520329
Neurology. 2003 Aug 26;61(4):500-6
pubmed: 12939424
Neurotox Res. 2016 Oct;30(3):295-337
pubmed: 27339162
Appl Neuropsychol. 2010 Jul;17(3):190-5
pubmed: 20799110
Vision Res. 2013 Sep 20;90:52-6
pubmed: 23231958
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Int J Geriatr Psychiatry. 2006 Jun;21(6):588-93
pubmed: 16783767
J Neuropsychiatry Clin Neurosci. 2000 Spring;12(2):233-9
pubmed: 11001602
J Alzheimers Dis. 2020;77(3):1025-1042
pubmed: 32804125
Dement Geriatr Cogn Dis Extra. 2021 Mar 19;11(1):51-57
pubmed: 33976692
Cereb Cortex. 1991 Jan-Feb;1(1):103-16
pubmed: 1822725