Acute and Sub-Acute Toxicity Evaluation of the Crude Methanolic Extract of
Justicia schimperiana
acute toxicity
crude extract
rats
sub-acute toxicity
Journal
Journal of experimental pharmacology
ISSN: 1179-1454
Titre abrégé: J Exp Pharmacol
Pays: New Zealand
ID NLM: 101530345
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
10
2023
accepted:
09
11
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
This study evaluates the acute and sub-acute toxicity of 80% methanolic extracts of the leaves of Dried powdered leaves of The single-dose oral administration of the plant resulted in no deaths or serious morbidity. The median lethal dose was >5000 mg/kg. The 28-day oral treatment of the plant extract had no significant effect on general behavior, food intake, organ weight, biochemical parameters, or the majority of the hematological markers, with the exception of the decrease in hemoglobin and hematocrit in the 1000 mg/kg extract-treated groups compared to the controls. Both sexes experienced significant weight increases at all dosage levels. With the exception of minor alterations in a few of the organs, no significant histological change was identified. It is concluded that the single-dose and repeated-dose 28-day oral administration of the methanolic leaf extract of
Identifiants
pubmed: 38026231
doi: 10.2147/JEP.S441273
pii: 441273
pmc: PMC10664716
doi:
Types de publication
Journal Article
Langues
eng
Pagination
467-483Informations de copyright
© 2023 Jegnie et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in this work.
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