Strategies and Progress of Raman Technologies for Cellular Uptake Analysis of the Drug Delivery Systems.

coherence Raman scattering drug delivery systems nanoparticle spontaneous Raman scattering surface-enhanced Raman scattering

Journal

International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847

Informations de publication

Date de publication:
2023
Historique:
received: 07 09 2023
accepted: 06 11 2023
medline: 1 12 2023
pubmed: 29 11 2023
entrez: 29 11 2023
Statut: epublish

Résumé

Nanoparticle (NP)-based drug delivery systems have the potential to significantly enhance the pharmacological and therapeutic properties of drugs. These systems enhance the bioavailability and biocompatibility of pharmaceutical agents via enabling targeted delivery to specific tissues or organs. However, the efficacy and safety of these systems are largely dependent on the cellular uptake and intracellular transport of NPs. Thus, it is crucial to monitor the intracellular behavior of NPs within a single cell. Yet, it is challenging due to the complexity and size of the cell. Recently, the development of the Raman instrumentation offers a versatile tool to allow noninvasive cellular measurements. The primary objective of this review is to highlight the most recent advancements in Raman techniques (spontaneous Raman scattering, bioorthogonal Raman scattering, coherence Raman scattering, and surface-enhanced Raman scattering) when it comes to assessing the internalization of NP-based drug delivery systems and their subsequent movement within cells.

Identifiants

pubmed: 38026519
doi: 10.2147/IJN.S435087
pii: 435087
pmc: PMC10674749
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

6883-6900

Informations de copyright

© 2023 Liu et al.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.

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Auteurs

Yajuan Liu (Y)

Key Laboratory of Molecular Target & Clinical Pharmacology, and the NMPA & State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.

Mei Li (M)

School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, People's Republic of China.

Haisha Liu (H)

School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, People's Republic of China.

Chao Kang (C)

School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, People's Republic of China.

Xiyong Yu (X)

Key Laboratory of Molecular Target & Clinical Pharmacology, and the NMPA & State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.

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Classifications MeSH