Albumin Proteins as Delivery Vehicles for PFAS Contaminants into Respiratory Membranes.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
21 Nov 2023
21 Nov 2023
Historique:
received:
22
08
2023
revised:
20
10
2023
accepted:
25
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Poly- and perfluoroalkyl substances (PFAS) are a family of chemicals that have been used in a wide range of commercial products. While their use is declining, the prevalence of PFAS, combined with their chemical longevity, ensures that detectable levels will remain in the environment for years to come. As such, there is a pressing need to understand how PFAS contaminants interact with other elements of the human exposome and the consequences of these interactions for human health. Using serum albumin as a model system, we show that proteins can bind PFAS contaminants and facilitate their incorporation into model pulmonary surfactant systems and lipid bilayers. Protein-mediated PFAS delivery significantly altered the structure and function of both model membrane systems, potentially contributing to respiratory dysfunction and airway diseases in vivo. These results provide valuable insights into the synergistic interaction between PFAS contaminants and other elements of the human exposome and their potential consequences for human health.
Identifiants
pubmed: 38027323
doi: 10.1021/acsomega.3c06239
pmc: PMC10666230
doi:
Types de publication
Journal Article
Langues
eng
Pagination
44036-44043Informations de copyright
© 2023 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Environ Int. 2023 Mar;173:107857
pubmed: 36881956
Methods Mol Biol. 2021;2223:101-114
pubmed: 33226590
Chemosphere. 2015 Jun;129:217-24
pubmed: 25497588
Int J Hyg Environ Health. 2023 Jul;252:114219
pubmed: 37451108
Biophys J. 2008 Sep 15;95(6):2779-91
pubmed: 18539636
Nature. 1997 Dec 11;390(6660):618-22
pubmed: 9403692
Indoor Air. 2017 Mar;27(2):377-385
pubmed: 27538819
Mol Cell Ther. 2016 Feb 27;4:3
pubmed: 26925240
Biochim Biophys Acta Biomembr. 2020 Jun 1;1862(6):183258
pubmed: 32142819
Chemosphere. 2021 Jan;263:128083
pubmed: 33297081
Eur Ann Allergy Clin Immunol. 2013 Aug 01;45(4):144-7
pubmed: 24067340
Biochem J. 1991 Sep 15;278 ( Pt 3):843-8
pubmed: 1898370
Front Allergy. 2021 Oct 28;2:769728
pubmed: 35386965
Biochim Biophys Acta. 2005 Dec 30;1720(1-2):14-21
pubmed: 16376294
J Environ Chem Eng. 2022 Apr;10(2):
pubmed: 35463622
Environ Toxicol Chem. 2021 Mar;40(3):631-657
pubmed: 33201517
J Colloid Interface Sci. 2012 Dec 15;388(1):162-9
pubmed: 23010317
Pediatr Clin North Am. 2007 Apr;54(2):375-98, ix
pubmed: 17448365
Respir Physiol Neurobiol. 2011 Mar 15;175(3):316-21
pubmed: 21185407
FEBS Lett. 2022 Oct;596(19):2555-2565
pubmed: 35891619
Langmuir. 2016 Oct 25;32(42):11055-11062
pubmed: 27723354
Exp Lung Res. 1996 Jan-Feb;22(1):33-49
pubmed: 8838134
Am J Obstet Gynecol. 1991 Feb;164(2):477-81
pubmed: 1992687
ACS Omega. 2018 Nov 30;3(11):15353-15360
pubmed: 30556004
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):
pubmed: 33688047
Allergy. 2020 Aug;75(8):2073-2077
pubmed: 32141090
Toxicol In Vitro. 2020 Feb;62:104656
pubmed: 31536757
Biochim Biophys Acta. 2007 May;1768(5):1299-308
pubmed: 17349969
Mucosal Immunol. 2014 May;7(3):684-93
pubmed: 24172847
Environ Sci Technol Lett. 2021 Oct 12;8(10):897-902
pubmed: 35359817
Am J Clin Nutr. 2002 Jan;75(1):119-25
pubmed: 11756069
Prostaglandins Other Lipid Mediat. 2019 Aug;143:106340
pubmed: 31129176
Allergy Asthma Immunol Res. 2009 Oct;1(1):45-7
pubmed: 20224670
Am J Physiol. 1998 Oct;275(4):L740-7
pubmed: 9755106
Environ Sci Technol. 2010 Jul 1;44(13):5263-9
pubmed: 20540534
Int J Environ Res Public Health. 2015 May 29;12(6):6098-114
pubmed: 26035660
Antioxid Redox Signal. 2019 Nov 1;31(13):954-993
pubmed: 31184204
Biochim Biophys Acta. 2013 Oct;1828(10):2294-305
pubmed: 23816442
Bio Protoc. 2020 Jul 20;10(14):
pubmed: 32953942
Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1079-85
pubmed: 12376361
Curr Environ Health Rep. 2021 Dec;8(4):323-335
pubmed: 34985714
Sci Rep. 2022 Aug 18;12(1):14104
pubmed: 35982171
Chest. 2000 Jul;118(1):164-74
pubmed: 10893374