Advantages and disadvantages of treatment of experimental ARDS by M2-polarized RAW 264.7 macrophages.
ARDS
Immune system
Inflammation
LPS
Lung
Macrophage
Polarization
Therapy
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
14
02
2023
revised:
20
09
2023
accepted:
31
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Innate immunity reactions are core to any immunological process, including systemic inflammation and such extremes as acute respiratory distress syndrome (ARDS) and cytokine storm. Macrophages, the key cells of innate immunity, show high phenotypic plasticity: depending on microenvironmental cues, they can polarize into M1 (classically activated, pro-inflammatory) or M2 (alternatively activated, anti-inflammatory). The anti-inflammatory M2 macrophage polarization-based cell therapies constitute a novel prospective modality. Systemic administration of 'educated' macrophages is intended at their homing in lungs in order to mitigate the pro-inflammatory cytokine production and reduce the risks of 'cytokine storm' and related severe complications. Acute respiratory distress syndrome (ARDS) is the main mortality factor in pneumonia including SARS-CoV-associated cases. This study aimed to evaluate the influence of infusions of RAW 264.7 murine macrophage cell line polarized towards M2 phenotype on the development of LPS-induced ARDS in mouse model. The results indicate that the M2-polarized RAW 264.7 macrophage infusions in the studied model of ARDS promote relocation of lymphocytes from their depots in immune organs to the lungs. In addition, the treatment facilitates expression of M2-polarization markers
Identifiants
pubmed: 38027880
doi: 10.1016/j.heliyon.2023.e21880
pii: S2405-8440(23)09088-6
pmc: PMC10658332
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e21880Informations de copyright
© 2023 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Timur Fatkhudinov reports financial support was provided by 10.13039/501100006769Russian Science Foundation.
Références
Chin Med J (Engl). 2021 Feb 17;134(6):699-707
pubmed: 33605598
Sci Rep. 2020 Sep 28;10(1):15884
pubmed: 32985516
Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53
pubmed: 22582175
JAMA. 2018 Feb 20;319(7):698-710
pubmed: 29466596
JCI Insight. 2020 Feb 27;5(4):
pubmed: 32102987
Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L379-99
pubmed: 18621912
J Immunol. 2021 Feb 1;206(3):540-553
pubmed: 33328213
Front Cell Infect Microbiol. 2020 Jun 12;10:340
pubmed: 32596170
Stem Cell Res Ther. 2015 May 20;6:97
pubmed: 25986930
Int J Mol Sci. 2021 Dec 24;23(1):
pubmed: 35008594
Onco Targets Ther. 2018 Oct 05;11:6579-6587
pubmed: 30323630
Cancer Immunol Immunother. 2021 May;70(5):1323-1339
pubmed: 33140190
Br J Pharmacol. 2020 Nov;177(22):5078-5095
pubmed: 32754917
Protein Cell. 2020 Oct;11(10):707-722
pubmed: 32519302
Signal Transduct Target Ther. 2022 Sep 5;7(1):307
pubmed: 36064538
Am J Physiol Cell Physiol. 2010 Dec;299(6):C1562-70
pubmed: 20861473
Blood. 2011 Oct 13;118(15):4199-208
pubmed: 21846901
Nat Commun. 2020 Feb 4;11(1):698
pubmed: 32019928
J Cardiovasc Transl Res. 2018 Jun;11(3):173-181
pubmed: 29392536
Cell Biol Int. 2017 Sep;41(9):960-968
pubmed: 28493530
J Immunol. 2010 Jun 1;184(11):6438-46
pubmed: 20483789
Mol Med Rep. 2017 Jan;15(1):131-138
pubmed: 27959438
Transl Res. 2022 Mar;241:13-24
pubmed: 34547499
Respir Care. 2017 Jan;62(1):113-122
pubmed: 27803355
J Immunol. 2016 Mar 1;196(5):2319-26
pubmed: 26800872
Trends Immunol. 2013 May;34(5):216-23
pubmed: 23218730
JAMA Oncol. 2017 Dec 1;3(12):1751
pubmed: 28750112
J Transl Med. 2017 Aug 29;15(1):181
pubmed: 28851381
J Control Release. 2020 Jul 10;323:179-190
pubmed: 32334322
Cell Signal. 2018 Jan;42:249-258
pubmed: 29080804
Ther Deliv. 2019 Apr;10(4):203-206
pubmed: 30991921
J Pharmacol Pharmacother. 2010 Jul;1(2):87-93
pubmed: 21350616
Front Pharmacol. 2023 Feb 24;14:1106733
pubmed: 36909201
Biomed Res Int. 2018 Aug 13;2018:7019759
pubmed: 30186866
N Engl J Med. 2000 May 4;342(18):1334-49
pubmed: 10793167
Cell Signal. 2018 Jun;46:43-51
pubmed: 29458096
Am Rev Respir Dis. 1986 May;133(5):913-27
pubmed: 3085564
J Leukoc Biol. 2021 Jan;109(1):13-22
pubmed: 33040384
Am J Med Sci. 2021 Jul;362(1):13-23
pubmed: 34090669
PLoS One. 2015 Dec 23;10(12):e0145342
pubmed: 26699615
Eur Respir J. 2022 Apr 14;59(4):
pubmed: 34446463
J Immunol. 2014 Jan 1;192(1):427-36
pubmed: 24337373
Biomed Pharmacother. 2019 Aug;116:109012
pubmed: 31146107
Stem Cell Res Ther. 2019 Nov 26;10(1):345
pubmed: 31771622
J Surg Res. 2020 Feb;246:450-456
pubmed: 31629496
Mol Med Rep. 2016 Aug;14(2):1681-92
pubmed: 27357811
Front Immunol. 2020 Jun 23;11:1298
pubmed: 32655570
Emerg Radiol. 2022 Feb;29(1):23-34
pubmed: 34698956
J Immunol. 2013 Sep 1;191(5):2290-8
pubmed: 23913966
Cells. 2019 Nov 27;8(12):
pubmed: 31783629
Front Immunol. 2019 Sep 04;10:2093
pubmed: 31552039
Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L711-8
pubmed: 22307908
Front Immunol. 2021 May 10;12:682871
pubmed: 34040616
Front Immunol. 2014 Oct 27;5:532
pubmed: 25386178
Respir Res. 2019 Jan 5;20(1):3
pubmed: 30611252
Ann Am Thorac Soc. 2016 Jul;13(7):1123-8
pubmed: 27159648
Cell Signal. 2014 Feb;26(2):192-7
pubmed: 24219909
Front Immunol. 2013 Aug 07;4:228
pubmed: 23966993
Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L733-46
pubmed: 26895644
Expert Rev Mol Med. 2005 Dec 02;7(27):1-26
pubmed: 16321172
Biomed Res Int. 2017;2017:4652695
pubmed: 28480221
J Cell Biochem. 2009 May 1;107(1):134-43
pubmed: 19241443
Stem Cells Transl Med. 2013 Nov;2(11):884-95
pubmed: 24089414
Oxid Med Cell Longev. 2021 Jun 13;2021:9973457
pubmed: 34234888
Semin Immunopathol. 2017 Jul;39(5):529-539
pubmed: 28466096
Front Oncol. 2022 Feb 17;12:775649
pubmed: 35251964
Bioinformatics. 2009 Nov 15;25(22):2906-12
pubmed: 19759197
J Cell Physiol. 2018 Sep;233(9):6425-6440
pubmed: 29319160
J Pathol. 2004 Feb;202(2):145-56
pubmed: 14743496
Nat Rev Immunol. 2005 Dec;5(12):917-27
pubmed: 16322745
Respir Res. 2021 Jul 3;22(1):194
pubmed: 34217280
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16766-71
pubmed: 25385603
Am J Respir Cell Mol Biol. 2005 Oct;33(4):319-27
pubmed: 16172252
Am J Physiol Lung Cell Mol Physiol. 2017 Feb 01;312(2):L217-L230
pubmed: 27881407
J Cell Physiol. 2020 Jan;235(1):281-293
pubmed: 31215024
J Neurovirol. 2000 May;6 Suppl 1:S70-81
pubmed: 10871768
Inflamm Res. 2020 Sep;69(9):883-895
pubmed: 32647933
Cell Mol Immunol. 2011 Jul;8(4):305-14
pubmed: 21460863
Genome Biol. 2021 Jan 27;22(1):50
pubmed: 33504367
Semin Immunol. 2015 Aug;27(4):249-56
pubmed: 26303100
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Front Immunol. 2014 Oct 27;5:533
pubmed: 25386179
Genes (Basel). 2020 Aug 20;11(9):
pubmed: 32825525
Inflammopharmacology. 2021 Feb;29(1):91-100
pubmed: 33159646
Am J Respir Crit Care Med. 2017 Aug 1;196(3):266-273
pubmed: 28306336
Front Immunol. 2017 Jul 06;8:774
pubmed: 28729866
Bioelectromagnetics. 2021 Sep;42(6):464-472
pubmed: 34130351
Crit Care. 2020 Jul 18;24(1):445
pubmed: 32682440
J Cytol Mol Biol. 2014 Jan 10;1(1):
pubmed: 24672807
Eur Respir J. 2011 Aug;38(2):318-28
pubmed: 21310883
Acta Pharm Sin B. 2022 Feb;12(2):600-620
pubmed: 34401226
PLoS One. 2018 Nov 5;13(11):e0206105
pubmed: 30395619
PLoS Med. 2007 Sep;4(9):e269
pubmed: 17803352
Stem Cell Res Ther. 2013 May 02;4(3):45
pubmed: 23673003
Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L709-25
pubmed: 24508730
Cancer Chemother Pharmacol. 2019 Feb;83(2):361-374
pubmed: 30506269
Respiration. 2014;87(4):329-42
pubmed: 24356493
J Clin Invest. 2012 Mar;122(3):787-95
pubmed: 22378047
Sci Rep. 2017 Aug 2;7(1):7143
pubmed: 28769058
Biomed Res Int. 2014;2014:462472
pubmed: 25133162
Br J Anaesth. 2004 Feb;92(2):277-9
pubmed: 14722184
J Inflamm Res. 2018 Nov 08;11:431-445
pubmed: 30519071
Dis Markers. 2016;2016:3501373
pubmed: 26980924
J Inflamm Res. 2019 Mar 11;12:73-86
pubmed: 30881082
Viruses. 2014 Feb 13;6(2):782-807
pubmed: 24531335
Immunobiology. 2010 Nov;215(11):884-93
pubmed: 20153075
Asian Pac J Allergy Immunol. 2020 Mar;38(1):1-9
pubmed: 32105090
J Acquir Immune Defic Syndr. 2017 Oct 1;76(2):219-224
pubmed: 28902679
Biochem Biophys Res Commun. 1995 Jan 17;206(2):667-73
pubmed: 7530004
ACS Cent Sci. 2020 Jul 22;6(7):1208-1222
pubmed: 32724855
Sci Rep. 2017 Jul 31;7(1):6877
pubmed: 28761077
Gut. 2010 Oct;59(10):1394-400
pubmed: 20675697
Methods Mol Biol. 2018;1809:17-30
pubmed: 29987779
Retrovirology. 2010 Apr 09;7:33
pubmed: 20380696
Am J Respir Crit Care Med. 2014 Apr 1;189(7):787-98
pubmed: 24559482
Pain Physician. 2020 Mar;23(2):E71-E83
pubmed: 32214286
Crit Care. 2018 Mar 8;22(1):60
pubmed: 29519254
Blood. 2010 Jan 14;115(2):353-62
pubmed: 19880493