Optoacoustic biomarkers of lipids, hemorrhage and inflammation in carotid atherosclerosis.
MSOT
RSOM
carotid artery disease
molecular imaging
stroke
unstable plaque
vulnerable plaque
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
04
2023
accepted:
18
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Imaging plays a critical role in exploring the pathophysiology and enabling the diagnostics and therapy assessment in carotid artery disease. Ultrasonography, computed tomography, magnetic resonance imaging and nuclear medicine techniques have been used to extract of known characteristics of plaque vulnerability, such as inflammation, intraplaque hemorrhage and high lipid content. Despite the plethora of available techniques, there is still a need for new modalities to better characterize the plaque and provide novel biomarkers that might help to detect the vulnerable plaque early enough and before a stroke occurs. Optoacoustics, by providing a multiscale characterization of the morphology and pathophysiology of the plaque could offer such an option. By visualizing endogenous (e.g., hemoglobin, lipids) and exogenous (e.g., injected dyes) chromophores, optoacoustic technologies have shown great capability in imaging lipids, hemoglobin and inflammation in different applications and settings. Herein, we provide an overview of the main optoacoustic systems and scales of detail that enable imaging of carotid plaques
Identifiants
pubmed: 38028502
doi: 10.3389/fcvm.2023.1210032
pmc: PMC10666780
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1210032Informations de copyright
© 2023 Karlas, Fasoula, Kallmayer, Schäffer, Angelis, Katsouli, Reidl, Duelmer, Al Adem, Hadjileontiadis, Eckstein and Ntziachristos.
Déclaration de conflit d'intérêts
VN discloses financial interests to iThera Medical GmbH, Spear UG, i3 Inc and sThesis GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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