E670G PCSK9 polymorphism in HeFH & CAD with diabetes: is the bridge to personalized therapy within reach?
CAD
Uzbek population
heterozygous familial hypercholesterolemia
pcsk9
type 2 diabetes mellitus
Journal
Frontiers in clinical diabetes and healthcare
ISSN: 2673-6616
Titre abrégé: Front Clin Diabetes Healthc
Pays: Switzerland
ID NLM: 9918266295306676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
08
2023
accepted:
11
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
To assess the distribution of PCSK9 E670G genetic polymorphism and PCSK9 levels in patients with Coronary Artery Disease (CAD) and Heterozygous Familial Hypercholesterolemia (HeFH), based on the presence of type 2 Diabetes Mellitus (T2DM). The study included 201 patients with chronic CAD, including those with HeFH (n=57, group I) and without it (n=144, group II). DLCN was used to diagnose HeFH. The PCSK9 E670G (rs505151) polymorphism was genetically typed using the PCR-RFLP procedure. In both the patient and control groups, the genotype frequency matched the Hardy-Weinberg equilibrium distribution (P>0.05). There were twice more G alleles in group I (13, 11.4%) than in group II (17, 6.0%), and thrice more (1, 3.0%) than in the healthy control group; nevertheless, these differences weren't statistically significant. Simultaneously, PCSK9 levels were higher in HeFH patients (P<0.05) compared to non-HeFH patients not taking statins (n=63). T2DM was equally represented in groups I and II (31.6% T2DM in patients with CAD, both with HeFH and non-HeFH, in the Uzbek population was significantly more often associated with the presence of the "gain-of-function" G allele of the PCSK9 E670G genetic polymorphism.
Identifiants
pubmed: 38028979
doi: 10.3389/fcdhc.2023.1277288
pmc: PMC10646404
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1277288Informations de copyright
Copyright © 2023 Alieva, Shek, Abdullaev, Fozilov, Khoshimov, Abdullaeva, Zakirova, Kurbanova, Kan and Kim.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Clin Endocrinol Metab. 2009 Jul;94(7):2537-43
pubmed: 19351729
Clin Investig Arterioscler. 2016 Mar-Apr;28(2):71-8
pubmed: 26743379
Diabetes Care. 2019 Mar;42(3):457-465
pubmed: 30617142
Can J Cardiol. 2013 Aug;29(8):927-33
pubmed: 23743349
Diabetes Metab Res Rev. 2016 Feb;32(2):193-9
pubmed: 26377225
Lancet Diabetes Endocrinol. 2019 Aug;7(8):618-628
pubmed: 31272931
Asian Pac J Trop Med. 2016 Feb;9(2):172-6
pubmed: 26919950
Cardiovasc Diabetol. 2020 Oct 6;19(1):167
pubmed: 33023603
Circ J. 2016;80(2):512-8
pubmed: 26632531
Front Cardiovasc Med. 2020 Nov 05;7:582865
pubmed: 33244470
Curr Probl Cardiol. 2022 Jul;47(7):101043
pubmed: 34780866
Eur Heart J. 2013 Dec;34(45):3478-90a
pubmed: 23956253
J Int Med Res. 2020 Jan;48(1):300060519839519
pubmed: 30947598
Nat Genet. 2005 Feb;37(2):161-5
pubmed: 15654334
Eur J Prev Cardiol. 2021 Sep 20;28(11):1279-1289
pubmed: 33580789
Hum Mutat. 2009 Jul;30(7):E682-91
pubmed: 19319977
Lipids Health Dis. 2015 Nov 17;14:149
pubmed: 26576960
Lancet Diabetes Endocrinol. 2017 Dec;5(12):941-950
pubmed: 28927706
Atherosclerosis. 2010 May;210(1):166-72
pubmed: 20006333
N Engl J Med. 2006 Mar 23;354(12):1264-72
pubmed: 16554528
Circulation. 2016 Jun 14;133(24):2459-502
pubmed: 27297342
Nat Genet. 2003 Jun;34(2):154-6
pubmed: 12730697
Front Genet. 2020 Sep 23;11:1020
pubmed: 33173529
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1288-93
pubmed: 19878649
BMC Med Genet. 2006 Jul 31;7:66
pubmed: 16875509
J Mol Neurosci. 2014 Jun;53(2):150-7
pubmed: 24599757
Eur Heart J. 2019 Jan 21;40(4):357-368
pubmed: 29982592
Diabetologia. 2015 Sep;58(9):2051-5
pubmed: 26049403
J Am Coll Cardiol. 2005 May 17;45(10):1611-9
pubmed: 15893176
Eur Heart J. 2018 Feb 1;39(5):354-359
pubmed: 29020353
J Clin Lipidol. 2015 Nov-Dec;9(6):786-793.e1
pubmed: 26687699
Cardiovasc Diabetol. 2022 Nov 28;21(1):263
pubmed: 36443827
Genet Test Mol Biomarkers. 2021 Sep;25(9):615-623
pubmed: 34550777
Lipids Health Dis. 2017 Jun 12;16(1):111
pubmed: 28606094
Am J Prev Cardiol. 2020 May 01;1:100012
pubmed: 34327453
Eur Heart J. 2017 Aug 21;38(32):2459-2472
pubmed: 28444290
Lancet Diabetes Endocrinol. 2016 Jun;4(6):537-47
pubmed: 27156051
Lancet. 2021 Nov 6;398(10312):1713-1725
pubmed: 34506743
Arch Med Sci. 2021 Nov 08;17(6):1447-1547
pubmed: 34900032