Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections.
CXCR3
DENV
JEV
autophagy
infection
interferon
mice
patients
platelet factor 4
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
received:
28
07
2023
revised:
05
11
2023
accepted:
10
11
2023
pubmed:
30
11
2023
medline:
30
11
2023
entrez:
29
11
2023
Statut:
aheadofprint
Résumé
Activated platelets secrete platelet factor 4 (PF4), which contributes to viral pathogenesis. Recently, we reported the proviral role of PF4 in replication of closely related flaviviruses, Japanese encephalitis virus (JEV) and dengue virus (DENV). This study aimed to investigate the detailed mechanism of PF4-mediated virus replication. PF4 PF4 These studies suggest that PF4 deficiency or inhibition of the PF4:CXCR3 pathway prevents JEV and DENV infection. The studies also highlight the PF4:CXCR3 axis as a potential target to develop treatment regimens against flaviviruses.
Sections du résumé
BACKGROUND
BACKGROUND
Activated platelets secrete platelet factor 4 (PF4), which contributes to viral pathogenesis. Recently, we reported the proviral role of PF4 in replication of closely related flaviviruses, Japanese encephalitis virus (JEV) and dengue virus (DENV).
OBJECTIVES
OBJECTIVE
This study aimed to investigate the detailed mechanism of PF4-mediated virus replication.
METHODS
METHODS
PF4
RESULTS
RESULTS
PF4
CONCLUSION
CONCLUSIONS
These studies suggest that PF4 deficiency or inhibition of the PF4:CXCR3 pathway prevents JEV and DENV infection. The studies also highlight the PF4:CXCR3 axis as a potential target to develop treatment regimens against flaviviruses.
Identifiants
pubmed: 38029855
pii: S1538-7836(23)00853-X
doi: 10.1016/j.jtha.2023.11.015
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 International Society on Thrombosis and Haemostasis. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interests All authors have no competing interests to disclose.