Continuous vs Bolus Thermodilution to Assess Microvascular Resistance Reserve.
CFR
FFR
angina
coronary artery disease
coronary flow
microvascular dysfunction
Journal
JACC. Cardiovascular interventions
ISSN: 1876-7605
Titre abrégé: JACC Cardiovasc Interv
Pays: United States
ID NLM: 101467004
Informations de publication
Date de publication:
27 Nov 2023
27 Nov 2023
Historique:
received:
29
05
2023
revised:
14
09
2023
accepted:
19
09
2023
medline:
1
12
2023
pubmed:
30
11
2023
entrez:
29
11
2023
Statut:
ppublish
Résumé
Coronary flow reserve (CFR) and microvascular resistance reserve (MRR) can, in principle, be derived by any method assessing coronary flow. The aim of this study was to compare CFR and MRR as derived by continuous (CFR A total of 175 patients with chest pain and nonobstructive coronary artery disease were studied. Bolus and continuous thermodilution measurements were performed in the left anterior descending coronary artery. MRR was calculated as the ratio of CFR to fractional flow reserve and corrected for changes in systemic pressure. In 102 patients, bolus and continuous thermodilution measurements were performed in duplicate to assess test-retest reliability. Mean CFR Compared with bolus thermodilution, continuous thermodilution yields lower values of CFR and MRR accompanied by an almost 3-fold reduction of the variability in the measured results.
Sections du résumé
BACKGROUND
BACKGROUND
Coronary flow reserve (CFR) and microvascular resistance reserve (MRR) can, in principle, be derived by any method assessing coronary flow.
OBJECTIVES
OBJECTIVE
The aim of this study was to compare CFR and MRR as derived by continuous (CFR
METHODS
METHODS
A total of 175 patients with chest pain and nonobstructive coronary artery disease were studied. Bolus and continuous thermodilution measurements were performed in the left anterior descending coronary artery. MRR was calculated as the ratio of CFR to fractional flow reserve and corrected for changes in systemic pressure. In 102 patients, bolus and continuous thermodilution measurements were performed in duplicate to assess test-retest reliability.
RESULTS
RESULTS
Mean CFR
CONCLUSIONS
CONCLUSIONS
Compared with bolus thermodilution, continuous thermodilution yields lower values of CFR and MRR accompanied by an almost 3-fold reduction of the variability in the measured results.
Identifiants
pubmed: 38030361
pii: S1936-8798(23)01322-5
doi: 10.1016/j.jcin.2023.09.027
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2767-2777Informations de copyright
Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding Support and Author Disclosures Drs Paolisso and Esposito are supported by a research grant from the CardioPaTh PhD Program. Dr Barbato has received speaker fees from Abbott Vascular, Boston Scientific, and GE Healthcare. Dr Collet has received research grants from Biosensors, GE Healthcare, Medis Medical Imaging, Pie Medical Imaging, CathWorks, Boston Scientific, Siemens, HeartFlow, and Abbott Vascular; and has received consultancy fees from HeartFlow, Opsens, Pie Medical Imaging, Abbott Vascular, and Philips. Dr De Bruyne has institutional consulting relationships with Boston Scientific, Abbott Vascular, CathWorks, Siemens, GE Healthcare, and Coroventis Research; has received institutional research grants from Abbott Vascular, Coroventis Research, CathWorks, and Boston Scientific; and has minor equity holdings in Philips, Siemens, GE Healthcare, Edwards Lifesciences, HeartFlow, Opsens, Celiad, Bayer, and Sanofi. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.