Multidisciplinary Treatment of Hepatocellular Carcinoma in 2023: Italian practice Treatment Guidelines of the Italian Association for the Study of the Liver (AISF), Italian Association of Medical Oncology (AIOM), Italian Association of Hepato-Bilio-Pancreatic Surgery (AICEP), Italian Association of Hospital Gastroenterologists (AIGO), Italian Association of Radiology and Clinical Oncology (AIRO), Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP), Italian Society of Surgery (SIC), Italian Society of Gastroenterology (SIGE), Italian Society of Medical and Interventional Radiology (SIRM), Italian Organ Transplant Society (SITO), and Association of Patients with Hepatitis and Liver Disease (EpaC) - Part I - Surgical treatments.

Adjuvant therapy Cirrhosis Guideline GRADE Hepatocellular carcinoma Immunotherapy Liver cancer Liver transplant Multidisciplinary board PICO Recurrence Resection Surgery Survival Transplant benefit

Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 20 06 2023
revised: 07 10 2023
accepted: 30 10 2023
medline: 30 11 2023
pubmed: 30 11 2023
entrez: 29 11 2023
Statut: aheadofprint

Résumé

Worldwide, hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. The remarkable improvements in treating HCC achieved in the last years have increased the complexity of HCC management. Following the need to have updated guidelines on the multidisciplinary treatment management of HCC, the Italian Scientific Societies involved in the management of this cancer have promoted the drafting of a new dedicated document. This document was drawn up according to the GRADE methodology needed to produce guidelines based on evidence. Here is presented the first part of guidelines, focused on the multidisciplinary tumor board of experts and surgical treatments of HCC.

Identifiants

DOI: 10.1016/j.dld.2023.10.029 PMID: 38030455
pubmed: 38030455
pii: S1590-8658(23)01019-8
doi: 10.1016/j.dld.2023.10.029
pii:
doi:

Types de publication

Practice Guideline

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest Giuseppe Cabibbo: Bayer, Eisai, Ipsen, MSD, AstraZeneca, Roche. Bruno Daniele: Astrazeneca, IPSEN, EISAI, MSD, Roche, Amgen, Incyte, Sanofi Mauro Borzio: none Andrea Casadei-Gardini: AstraZeneca, Bayer, Eisai, Incyte, Ipsen, IQVIA, MSD, Roche, Servier Umberto Cillo: none Agostino Colli: none Massimiliano Conforti: none Vincenzo Dadduzio: MSD, Ipsen, AstraZeneca, Amgen Francesco Dionisi: none Fabio Farinati: none Ivan Gardini: none Edoardo Giovanni Giannini: Rita Golfieri: Bayer, Bracco, Astra Zeneca Maria Guido: none Andrea Mega: none Silvia Minozzi: none Fabio Piscaglia: Astrazeneca, Bayer, Bracco, ESAOTE, EISAI, Exact Sciences, IPSEN, MSD, Roche, Samsung, Siemens Healthineers Lorenza Rimassa: LR reports consulting fees from AstraZeneca, Basilea, Bayer, BMS, Eisai, Exelixis, Genenta, Hengrui, Incyte, Ipsen, IQVIA, Lilly, MSD, Nerviano Medical Sciences, Roche, Servier, Taiho Oncology, Zymeworks; lecture fees from AstraZeneca, Bayer, Eisai, Gilead, Incyte, Ipsen, Merck Serono, Roche, Sanofi, Servier; travel expenses from AstraZeneca; research grants (to Institution) from Agios, AstraZeneca, BeiGene, Eisai, Exelixis, Fibro-gen, Incyte, Ipsen, Lilly, MSD, Nerviano Medical Sciences, Roche, Zymeworks Laura Romanini: none Anna Pecorelli: none Rodolfo Sacco: none Marta Scorsetti: none Luca Viganò: none Alessandro Vitale: none Franco Trevisani: AstraZeneca, Abbvie, Bayer, BMS, Eisai, Gilead, MSD, Roche

Auteurs

Giuseppe Cabibbo (G)

Section of Gastroenterology and Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo, Italy; Gastroenterology Unit, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone", Palermo, Italy. Electronic address: giuseppe.cabibbo@unipa.it.

Bruno Daniele (B)

Oncology Unit, Ospedale del Mare, ASL Napoli 1 Centro, Napoli, Italy.

Mauro Borzio (M)

Centro Diagnostico Italiano (CDI), Milano, Italy.

Andrea Casadei-Gardini (A)

Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.

Umberto Cillo (U)

General Surgery 2-Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy.

Agostino Colli (A)

Dipartimento di Medicina Trasfusionale ed Ematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

Massimiliano Conforti (M)

EpaC Onlus, Italian Liver Patient Association, Turin, Italy.

Vincenzo Dadduzio (V)

Medical Oncology Unit, "Mons. A.R.Dimiccoli" Hospital, Barletta, ASL BT, Italy.

Francesco Dionisi (F)

Department of Radiation Oncology, IRCCS Regina Elena National Cancer Institute - Rome, Italy.

Fabio Farinati (F)

Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy; Gastroenterology Unit, Azienda Ospedale-Università di Padova, 35128 Padova, Italy.

Ivan Gardini (I)

EpaC Onlus, Italian Liver Patient Association, Turin, Italy.

Edoardo Giovanni Giannini (EG)

Gastroenterology Unit, Department of Internal Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Rita Golfieri (R)

Alma Mater Studiorum" Bologna University, Bologna, Italy; Radiology Unit Madre Fortunata Toniolo Private Hospital, coordinator of Radiology centers Medipass Bologna, Bologna, Italy.

Maria Guido (M)

Department of Medicine, University of Padova, Padova- Italy.

Andrea Mega (A)

Department of Gastronterology, Regional Hospital Bolzano, Italy.

Silvia Minozzi (S)

Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri, IRCCS, Milano, Italy.

Fabio Piscaglia (F)

Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Italy.

Lorenza Rimassa (L)

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy.

Laura Romanini (L)

Radiology Unit, Ospedale di Cremona, ASST Cremona, Cremona, Italy.

Anna Pecorelli (A)

Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Rodolfo Sacco (R)

Gastroenterology and Endoscopy Unit, Department of Surgical and Medical Sciences, University of Foggia, 71100 Foggia, Italy.

Marta Scorsetti (M)

Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy; Department of Radiotherapy and Radiosurgery, Humanitas Research Hospital IRCCS, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

Luca Viganò (L)

Hepatobiliary Unit, Department of Minimally Invasive General & Oncologic Surgery, Humanitas Gavazzeni University Hospital, Viale M. Gavazzeni 21, 24125 Bergamo, Italy; Department of Biomedical Sciences, Humanitas University, Viale Rita Levi Montalcini 4, 20090 Milan, Italy.

Alessandro Vitale (A)

General Surgery 2-Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy.

Franco Trevisani (F)

Department of Medical and Surgical Sciences, University of Bologna, Italy; Unit of Semeiotics, Liver and Alcohol-Related Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy. Electronic address: franco.trevisani@unibo.it.

Classifications MeSH