Homologous chromosome pairing: The linchpin of accurate segregation in meiosis.
Linker of nucleoskeleton and cytoskeleton complex
homolog pairing
homologous recombination
meiosis
synapsis
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
30 Nov 2023
30 Nov 2023
Historique:
revised:
13
11
2023
received:
09
09
2023
accepted:
20
11
2023
medline:
30
11
2023
pubmed:
30
11
2023
entrez:
30
11
2023
Statut:
aheadofprint
Résumé
Meiosis is a specialized cell division that occurs in sexually reproducing organisms, generating haploid gametes containing half the chromosome number through two rounds of cell division. Homologous chromosomes pair and prepare for their proper segregation in subsequent divisions. How homologous chromosomes recognize each other and achieve pairing is an important question. Early studies showed that in most organisms, homologous pairing relies on homologous recombination. However, pairing mechanisms differ across species. Evidence indicates that chromosomes are dynamic and move during early meiotic stages, facilitating pairing. Recent studies in various model organisms suggest conserved mechanisms and key regulators of homologous chromosome pairing. This review summarizes these findings and compare similarities and differences in homologous chromosome pairing mechanisms across species.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31900557
Organisme : National Natural Science Foundation of China
ID : 32370780
Organisme : National Natural Science Foundation of China
ID : 32022018
Organisme : China Postdoctoral Science Foundation Grant
ID : 2019M662431
Informations de copyright
© 2023 Wiley Periodicals LLC.
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