The Eph/ephrin system symphony of gut inflammation.
Enteric nervous system
Enteric neuroimmune interaction
Eph/ephrin
Gut homeostasis
Gut inflammation
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
06
06
2023
revised:
15
10
2023
accepted:
26
10
2023
medline:
1
12
2023
pubmed:
30
11
2023
entrez:
30
11
2023
Statut:
ppublish
Résumé
The extent of gut inflammation depends largely on the gut barrier's integrity and enteric neuroimmune interactions. However, the factors and molecular mechanisms that regulate inflammation-related changes in the enteric nervous system (ENS) remain largely unexplored. Eph/ephrin signaling is critical for inflammatory response, neuronal activation, and synaptic plasticity in the brain, but its presence and function in the ENS have been largely unknown to date. This review discusses the critical role of Eph/ephrin in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways. Targeting the Eph/ephrin system offers innovative treatments for gut inflammation disorders, offering hope for enhanced patient prognosis, pain management, and overall quality of life.
Identifiants
pubmed: 38032293
pii: S1043-6618(23)00332-8
doi: 10.1016/j.phrs.2023.106976
pii:
doi:
Substances chimiques
Ephrins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106976Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.