Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
03
05
2023
accepted:
05
09
2023
medline:
4
12
2023
pubmed:
30
11
2023
entrez:
30
11
2023
Statut:
epublish
Résumé
The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and has been shown to reduce the transmission of dengue and other Aedes-borne viruses. Here we report the entomological results from phased, large-scale releases of Wolbachia infected Ae. aegypti mosquitoes throughout three contiguous cities located in the Aburrá Valley, Colombia. Local wMel Wolbachia-infected Ae. aegypti mosquitoes were generated and then released in an initial release pilot area in 2015-2016, which resulted in the establishment of Wolbachia in the local mosquito populations. Subsequent large-scale releases, mainly involving vehicle-based releases of adult mosquitoes along publicly accessible roads and streets, were undertaken across 29 comunas throughout Bello, Medellín and Itagüí Colombia between 2017-2022. In 9 comunas these were supplemented by egg releases that were undertaken by staff or community members. By the most recent monitoring, Wolbachia was found to be stable and established at consistent levels in local mosquito populations (>60% prevalence) in the majority (67%) of areas. These results, from the largest contiguous releases of wMel Wolbachia mosquitoes to date, highlight the operational feasibility of implementing the method in large urban settings. Based on results from previous studies, we expect that Wolbachia establishment will be sustained long term. Ongoing monitoring will confirm Wolbachia persistence in local mosquito populations and track its establishment in the remaining areas.
Sections du résumé
BACKGROUND
BACKGROUND
The wMel strain of Wolbachia has been successfully introduced into Aedes aegypti mosquitoes and has been shown to reduce the transmission of dengue and other Aedes-borne viruses. Here we report the entomological results from phased, large-scale releases of Wolbachia infected Ae. aegypti mosquitoes throughout three contiguous cities located in the Aburrá Valley, Colombia.
METHODOLOGY/PRINCIPAL FINDINGS
RESULTS
Local wMel Wolbachia-infected Ae. aegypti mosquitoes were generated and then released in an initial release pilot area in 2015-2016, which resulted in the establishment of Wolbachia in the local mosquito populations. Subsequent large-scale releases, mainly involving vehicle-based releases of adult mosquitoes along publicly accessible roads and streets, were undertaken across 29 comunas throughout Bello, Medellín and Itagüí Colombia between 2017-2022. In 9 comunas these were supplemented by egg releases that were undertaken by staff or community members. By the most recent monitoring, Wolbachia was found to be stable and established at consistent levels in local mosquito populations (>60% prevalence) in the majority (67%) of areas.
CONCLUSION
CONCLUSIONS
These results, from the largest contiguous releases of wMel Wolbachia mosquitoes to date, highlight the operational feasibility of implementing the method in large urban settings. Based on results from previous studies, we expect that Wolbachia establishment will be sustained long term. Ongoing monitoring will confirm Wolbachia persistence in local mosquito populations and track its establishment in the remaining areas.
Identifiants
pubmed: 38032856
doi: 10.1371/journal.pntd.0011642
pii: PNTD-D-23-00541
pmc: PMC10688688
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0011642Informations de copyright
Copyright: © 2023 Velez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Curr Biol. 2019 Dec 16;29(24):4241-4248.e5
pubmed: 31761702
Nature. 2019 Aug;572(7767):56-61
pubmed: 31316207
PLoS Negl Trop Dis. 2022 Apr 26;16(4):e0010324
pubmed: 35471983
PLoS Negl Trop Dis. 2022 Apr 20;16(4):e0010284
pubmed: 35442957
Trop Med Int Health. 2009 Nov;14(11):1351-5
pubmed: 19735371
PLoS Negl Trop Dis. 2020 Apr 17;14(4):e0008157
pubmed: 32302295
PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2688
pubmed: 24587459
Lancet Infect Dis. 2022 Nov;22(11):1587-1595
pubmed: 36182679
PLoS Biol. 2017 May 30;15(5):e2001894
pubmed: 28557993
Am J Trop Med Hyg. 2018 Feb;98(2):402-409
pubmed: 29313471
Gates Open Res. 2018 Nov 1;2:36
pubmed: 30596205
Nat Biotechnol. 2012 Sep;30(9):828-30
pubmed: 22965050
J Med Entomol. 1980 Dec 30;17(6):567-8
pubmed: 6111610
Trop Med Health. 2019 Jan 04;47:2
pubmed: 30787670
Insects. 2020 Nov 07;11(11):
pubmed: 33171885
Sci Rep. 2021 May 11;11(1):10039
pubmed: 33976301
Gates Open Res. 2020 May 11;4:50
pubmed: 32803130
PLoS Negl Trop Dis. 2019 Oct 28;13(10):e0007771
pubmed: 31658265
J Vector Ecol. 2016 Jun;41(1):1-10
pubmed: 27232118
PLoS Negl Trop Dis. 2017 Jul 20;11(7):e0005625
pubmed: 28727779
Parasit Vectors. 2015 Oct 28;8:563
pubmed: 26510523
PLoS Negl Trop Dis. 2021 Dec 14;15(12):e0010001
pubmed: 34905537
Parasit Vectors. 2014 Feb 03;7:58
pubmed: 24495395
Biomedica. 2023 Mar 30;43(1):131-144
pubmed: 37167464
PLoS One. 2013;8(3):e58824
pubmed: 23520534
PLoS Pathog. 2020 Apr 13;16(4):e1008433
pubmed: 32282862
Am Nat. 2011 Mar;177(3):323-33
pubmed: 21460541
Cell. 2009 Dec 24;139(7):1268-78
pubmed: 20064373
PLoS Negl Trop Dis. 2015 Jul 02;9(7):e0003864
pubmed: 26135160
Nature. 2011 Aug 24;476(7361):454-7
pubmed: 21866160
PLoS Negl Trop Dis. 2016 Apr 28;10(4):e0004677
pubmed: 27124663
Gates Open Res. 2021 Sep 24;5:147
pubmed: 35602266
PLoS Negl Trop Dis. 2019 Jan 8;13(1):e0007023
pubmed: 30620733
Gates Open Res. 2020 Jul 17;4:109
pubmed: 33103066
J Vis Exp. 2014 Jan 04;(83):e3579
pubmed: 24430003
Gates Open Res. 2019 Sep 26;3:1547
pubmed: 31667465
Front Microbiol. 2021 Jul 29;12:711107
pubmed: 34394061
Acta Trop. 2019 Mar;191:146-154
pubmed: 30552882
Nature. 2011 Aug 24;476(7361):450-3
pubmed: 21866159
Parasit Vectors. 2015 Jun 12;8:325
pubmed: 26068925
Nat Biotechnol. 2020 Apr;38(4):482-492
pubmed: 32265562
PLoS Negl Trop Dis. 2021 Jul 12;15(7):e0009556
pubmed: 34252106
J Virol. 2013 Nov;87(21):11945-9
pubmed: 23986574
Sci Rep. 2016 Jul 01;6:28792
pubmed: 27364935
Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):
pubmed: 34607949
Sci Adv. 2017 Feb 17;3(2):e1602024
pubmed: 28232955
PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3115
pubmed: 25211492
N Engl J Med. 2021 Jun 10;384(23):2177-2186
pubmed: 34107180
PLoS Negl Trop Dis. 2021 Sep 7;15(9):e0009752
pubmed: 34492017
J Med Entomol. 2019 Sep 3;56(5):1296-1303
pubmed: 31008514