Muscarinic acetylcholine receptors M
acetylcholine-dependent inwardly rectifying potassium channel
atrioventricular node
cardiac conduction
equine
muscarinic receptor
parasympathetic activity
second-degree AV block
vagus
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
11
2022
accepted:
30
10
2023
medline:
30
11
2023
pubmed:
30
11
2023
entrez:
30
11
2023
Statut:
epublish
Résumé
Second-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone. To assess whether AV block in horses is due to altered expression of the effectors of vagal signalling in the AV node, with specific emphasis on the muscarinic acetylcholine receptor (M Eighteen horses with a low burden of second-degree AV block (median 8 block per 20 h, IQR: 32 per 20 h) were assigned to the The AV block group had a significantly longer PR interval (mean ± SD, 0.40 ± 0.05 s; Here, we demonstrate the involvement of the m
Sections du résumé
Background
UNASSIGNED
Second-degree atrioventricular (AV) block at rest is very common in horses. The underlying molecular mechanisms are unexplored, but commonly attributed to high vagal tone.
Aim
UNASSIGNED
To assess whether AV block in horses is due to altered expression of the effectors of vagal signalling in the AV node, with specific emphasis on the muscarinic acetylcholine receptor (M
Method
UNASSIGNED
Eighteen horses with a low burden of second-degree AV block (median 8 block per 20 h, IQR: 32 per 20 h) were assigned to the
Results
UNASSIGNED
The AV block group had a significantly longer PR interval (mean ± SD, 0.40 ± 0.05 s;
Conclusion
UNASSIGNED
Here, we demonstrate the involvement of the m
Identifiants
pubmed: 38034369
doi: 10.3389/fcvm.2023.1102164
pmc: PMC10687567
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1102164Subventions
Organisme : British Heart Foundation
ID : FS/19/1/34035
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/22/10919
Pays : United Kingdom
Informations de copyright
© 2023 Nissen, Saljic, Carstensen, Braunstein, Hesselkilde, Kjeldsen, Hopster-Iversen, D'Souza, Jespersen and Buhl.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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