Endothelial activation and damage as a common pathological substrate in different pathologies and cell therapy complications.
COVID-19
cardiovascular disease
chronic kidney disease
endothelial damage
hematopoietic stem cell transplantation
major depression
obesity
sepsis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
08
2023
accepted:
30
10
2023
medline:
30
11
2023
pubmed:
30
11
2023
entrez:
30
11
2023
Statut:
epublish
Résumé
The endothelium is a biologically active interface with multiple functions, some of them common throughout the vascular tree, and others that depend on its anatomical location. Endothelial cells are continually exposed to cellular and humoral factors, and to all those elements (biological, chemical, or hemodynamic) that circulate in blood at a certain time. It can adapt to different stimuli but this capability may be lost if the stimuli are strong enough and/or persistent in time. If the endothelium loses its adaptability it may become dysfunctional, becoming a potential real danger to the host. Endothelial dysfunction is present in multiple clinical conditions, such as chronic kidney disease, obesity, major depression, pregnancy-related complications, septic syndromes, COVID-19, and thrombotic microangiopathies, among other pathologies, but also in association with cell therapies, such as hematopoietic stem cell transplantation and treatment with chimeric antigen receptor T cells. In these diverse conditions, evidence suggests that the presence and severity of endothelial dysfunction correlate with the severity of the associated disease. More importantly, endothelial dysfunction has a strong diagnostic and prognostic value for the development of critical complications that, although may differ according to the underlying disease, have a vascular background in common. Our multidisciplinary team of women has devoted many years to exploring the role of the endothelium in association with the mentioned diseases and conditions. Our research group has characterized some of the mechanisms and also proposed biomarkers of endothelial damage. A better knowledge would provide therapeutic strategies either to prevent or to treat endothelial dysfunction.
Identifiants
pubmed: 38034541
doi: 10.3389/fmed.2023.1285898
pmc: PMC10682735
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1285898Informations de copyright
Copyright © 2023 Palomo, Moreno-Castaño, Salas, Escribano-Serrat, Rovira, Guillen-Olmos, Fernandez, Ventosa-Capell, Youssef, Crispi, Nomdedeu, Martinez-Sanchez, De Moner and Diaz-Ricart.
Déclaration de conflit d'intérêts
MD-R has received honoraria from Jazz and research funding from Zacros (Fujimori Kogyo Co., Ltd., Japan), Cellphire Therapeutics (USA), CSL Behring (Spain), and Sysmex Europe GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Immunol. 2019 Oct 11;10:2400
pubmed: 31681291
J Thromb Haemost. 2005 Jul;3(7):1392-406
pubmed: 15892866
Atherosclerosis. 2011 Jun;216(2):446-51
pubmed: 21414625
Diabetes. 2007 Apr;56(4):901-11
pubmed: 17395738
Lancet. 2016 Mar 5;387(10022):999-1011
pubmed: 26342729
Blood Adv. 2018 Jun 26;2(12):1495-1509
pubmed: 29945939
J Am Coll Cardiol. 2007 Jul 17;50(3):217-24
pubmed: 17631213
J Exp Med. 2005 Oct 3;202(7):907-12
pubmed: 16203864
Curr Stem Cell Res Ther. 2010 Dec;5(4):294-302
pubmed: 20528750
Circ Res. 2005 May 13;96(9):939-49
pubmed: 15890981
J Thromb Haemost. 2023 Aug;21(8):2020-2031
pubmed: 37178769
Blood. 2023 May 18;141(20):2430-2442
pubmed: 36989488
Blood Adv. 2021 Jan 26;5(2):593-601
pubmed: 33496754
Nat Med. 2010 Apr;16(4):396-9
pubmed: 20376052
Circulation. 2004 Oct 5;110(14):2003-9
pubmed: 15451797
Circ Res. 2007 Feb 2;100(2):158-73
pubmed: 17272818
Front Immunol. 2021 May 19;12:623610
pubmed: 34093519
Clin Chim Acta. 2019 Aug;495:606-610
pubmed: 31181192
Front Med (Lausanne). 2022 Apr 25;9:811504
pubmed: 35547236
Cardiol Clin. 2022 Aug;40(3):277-285
pubmed: 35851451
PLoS One. 2020 Nov 4;15(11):e0241778
pubmed: 33147257
Blood. 2002 Jul 1;100(1):334-40
pubmed: 12070045
Lancet. 2010 Jun 12;375(9731):2073-81
pubmed: 20483451
Bone Marrow Transplant. 2022 Aug;57(8):1217-1239
pubmed: 35589997
Bone Marrow Transplant. 2018 Apr;53(4):449-456
pubmed: 29330398
Arterioscler Thromb Vasc Biol. 2007 May;27(5):996-1003
pubmed: 17303782
Biol Blood Marrow Transplant. 2010 Oct;16(10):1463-6
pubmed: 20685260
Br J Haematol. 2021 Apr;193(1):43-51
pubmed: 33538335
Vascul Pharmacol. 2007 Jan;46(1):1-9
pubmed: 16920035
High Blood Press Cardiovasc Prev. 2023 Jan;30(1):45-54
pubmed: 36508151
Thromb Haemost. 2023 Oct;123(10):931-944
pubmed: 37172941
Front Cardiovasc Med. 2022 Mar 07;9:856923
pubmed: 35345482
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
EJHaem. 2021 Nov 24;3(Suppl 1):6-10
pubmed: 35844299
EJHaem. 2021 Jun 22;2(3):680-681
pubmed: 34518829
BMC Pregnancy Childbirth. 2018 Feb 27;18(1):60
pubmed: 29482567
J Clin Lab Anal. 2019 May;33(4):e22834
pubmed: 30666720
Nat Med. 2018 Jun;24(6):731-738
pubmed: 29808005
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Nephrol Dial Transplant. 2011 Nov;26(11):3537-43
pubmed: 21378154
J Clin Invest. 2007 Jan;117(1):175-84
pubmed: 17200717
Best Pract Res Clin Haematol. 2008 Jun;21(2):139-48
pubmed: 18503982
Kidney Int Rep. 2021 Jan;6(1):11-23
pubmed: 33102952
Bone Marrow Transplant. 2011 Dec;46(12):1495-502
pubmed: 21460864
Front Immunol. 2022 Jul 08;13:883404
pubmed: 35880174
Rev Med Virol. 2023 Jul;33(4):e2442
pubmed: 36943015
Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1719-1732
pubmed: 31694864
Toxins (Basel). 2018 Oct 12;10(10):
pubmed: 30322010
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Shock. 2009 Apr;31(4):335-41
pubmed: 18791498
Haematologica. 2023 Aug 01;108(8):2067-2079
pubmed: 36794498
J Am Coll Cardiol. 2005 Aug 16;46(4):656-9
pubmed: 16098431
Front Immunol. 2019 Oct 09;10:2339
pubmed: 31649666
Cardiovasc Res. 2009 Nov 1;84(2):309-16
pubmed: 19541671
J Leukoc Biol. 2008 Mar;83(3):536-45
pubmed: 18032692
Sci Rep. 2021 Feb 4;11(1):3048
pubmed: 33542402
Obstet Gynecol. 2019 Jan;133(1):1
pubmed: 30575675
J Thromb Haemost. 2021 Aug;19(8):1948-1958
pubmed: 33872468
J Virol. 2021 Aug 10;95(17):e0079421
pubmed: 34160250
Bone Marrow Transplant. 1996 Nov;18(5):955-9
pubmed: 8932851
Blood Adv. 2019 Aug 13;3(15):2424-2435
pubmed: 31409584
Cardiovasc Res. 2020 Dec 1;116(14):2177-2184
pubmed: 32750108
Rev Cardiovasc Med. 2020 Sep 30;21(3):315-319
pubmed: 33070537
Semin Thromb Hemost. 2007 Mar;33(2):128-35
pubmed: 17340460
Nefrologia. 2015;35(5):421-47
pubmed: 26456110
Biol Blood Marrow Transplant. 2020 May;26(5):865-875
pubmed: 31786240
Nephrol Dial Transplant. 2016 May;31(5):737-46
pubmed: 25883197
Lancet Haematol. 2021 May;8(5):e355-e364
pubmed: 33894170
Front Immunol. 2022 Apr 08;13:877477
pubmed: 35464403
Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):728-35
pubmed: 26891741
Int J Mol Sci. 2020 May 29;21(11):
pubmed: 32485958
Microvasc Res. 2021 Nov;138:104224
pubmed: 34273359
Nephrol Dial Transplant. 2010 Aug;25(8):2571-6
pubmed: 20179005
Clin Cardiol. 2018 Feb;41(2):239-246
pubmed: 29446836
Blood Adv. 2021 Jul 27;5(14):2799-2806
pubmed: 34264268
Front Oncol. 2020 Jun 24;10:885
pubmed: 32670871
Heart. 2000 Feb;83(2):205-9
pubmed: 10648498
Front Med (Lausanne). 2022 Mar 03;9:813343
pubmed: 35308523
Eur Heart J. 2020 Sep 1;41(32):3038-3044
pubmed: 32882706
Biol Blood Marrow Transplant. 2010 Jul;16(7):985-93
pubmed: 20167280
Oncogene. 2017 Sep 28;36(39):5445-5459
pubmed: 28534515
PLoS One. 2015 Jul 01;10(7):e0132047
pubmed: 26132137
Blood. 2017 Nov 23;130(21):2295-2306
pubmed: 28924019
Nat Rev Dis Primers. 2023 Feb 16;9(1):8
pubmed: 36797292
Int J Mol Sci. 2022 Sep 04;23(17):
pubmed: 36077539
J Immunother. 2010 Jan;33(1):1-7
pubmed: 19952961
Clin Dermatol. 2021 Nov-Dec;39(6):934-965
pubmed: 34920833
Front Immunol. 2023 May 15;14:1188049
pubmed: 37256141
Biol Blood Marrow Transplant. 2013 Oct;19(10):1439-45
pubmed: 23845694
J Immunother Cancer. 2023 Apr;11(4):
pubmed: 37045474
PLoS One. 2012;7(8):e43374
pubmed: 22937042
Ann Hematol. 2019 Jul;98(7):1721-1732
pubmed: 31055613
Blood. 2007 Jan 15;109(2):613-5
pubmed: 16990601
J Clin Med. 2023 Jan 18;12(3):
pubmed: 36769407
Shock. 2015 Jun;43(6):556-62
pubmed: 25643015
Bone Marrow Transplant. 1990 Jan;5(1):39-42
pubmed: 2137021
Sci Rep. 2021 Jul 13;11(1):14422
pubmed: 34257400
Toxins (Basel). 2020 Jun 01;12(6):
pubmed: 32492843
Front Immunol. 2020 Dec 16;11:577027
pubmed: 33391257
J Immunother Cancer. 2023 Jun;11(6):
pubmed: 37295816
Nephrol Dial Transplant. 2020 Sep 1;35(9):1478-1487
pubmed: 31071222
Nephrol Dial Transplant. 2003 Jun;18(6):1079-85
pubmed: 12748338
Intensive Care Med. 2010 Aug;36(8):1286-98
pubmed: 20443110
Blood. 1995 Dec 1;86(11):4184-93
pubmed: 7492776
Am J Hypertens. 2001 Jun;14(6 Pt 2):44S-54S
pubmed: 11411765
Am J Cardiol. 2005 Oct 1;96(7):1016-21
pubmed: 16188535
Ann Hematol. 1998 Feb;76(2):61-5
pubmed: 9540759
Innate Immun. 2015 Nov;21(8):827-46
pubmed: 26403174
Clin Kidney J. 2020 Nov 06;14(4):1055-1066
pubmed: 33841853
Bone Marrow Transplant. 1992 Sep;10(3):197-214
pubmed: 1422475
Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2404-2407
pubmed: 32762443
Shock. 2022 Jan 1;57(1):95-105
pubmed: 34172614
Nat Rev Immunol. 2007 Oct;7(10):803-15
pubmed: 17893694
Nat Rev Immunol. 2022 Feb;22(2):85-96
pubmed: 34002066
Nefrologia. 2017 Jan - Feb;37(1):9-19
pubmed: 27553986
Am J Obstet Gynecol. 2022 Aug;227(2):277.e1-277.e16
pubmed: 35351411
Hypertension. 2022 Oct;79(10):2274-2287
pubmed: 35993233
Circ Res. 2000 Sep 29;87(7):603-7
pubmed: 11009566
Transl Psychiatry. 2016 Sep 06;6(9):e886
pubmed: 27598970
J Thromb Haemost. 2011 Jun;9(6):1236-45
pubmed: 21481180
Biol Blood Marrow Transplant. 2015 Oct;21(10):1739-45
pubmed: 26172478
Glob Heart. 2020 Sep 22;15(1):64
pubmed: 33150129
Semin Thromb Hemost. 2022 Nov;48(8):978-987
pubmed: 36100234
Eur Respir J. 2021 Sep 9;58(3):
pubmed: 33958433
Bioessays. 1994 Dec;16(12):901-6
pubmed: 7840769
Reprod Sci. 2017 Oct;24(10):1362-1370
pubmed: 28891416
N Engl J Med. 2016 Jan 7;374(1):13-22
pubmed: 26735990
Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E735-48
pubmed: 19549791
Br J Haematol. 2023 Apr;201(1):86-94
pubmed: 36503182
Bone Marrow Transplant. 2020 Dec;55(12):2270-2278
pubmed: 32404979
Nat Rev Microbiol. 2010 Feb;8(2):93-104
pubmed: 20040916
J Intensive Care. 2015 Jan 07;3(1):1
pubmed: 25705426
Bone Marrow Transplant. 2018 Dec;53(12):1541-1547
pubmed: 29706650
Bone Marrow Transplant. 1996 Feb;17(2):277-80
pubmed: 8640179
Int J Mol Sci. 2023 Feb 20;24(4):
pubmed: 36835587
Mol Ther Methods Clin Dev. 2018 Dec 06;12:134-144
pubmed: 30623002
Biol Blood Marrow Transplant. 2020 Jul;26(7):1247-1256
pubmed: 32165328
Microcirculation. 2014 Jan;21(1):15-25
pubmed: 23981199
Front Med (Lausanne). 2023 Jun 02;10:1203827
pubmed: 37332755
Thromb Haemost. 2001 Oct;86(4):1099-105
pubmed: 11686330
Front Immunol. 2022 Nov 21;13:1050994
pubmed: 36479117
Bone Marrow Transplant. 2023 Apr;58(4):407-413
pubmed: 36639572
Int J Mol Sci. 2014 Jun 25;15(7):11324-49
pubmed: 24968272
FEBS J. 2020 Mar;287(6):1088-1100
pubmed: 31736207
Hematol Oncol. 2023 Oct;41(4):704-717
pubmed: 37186314
Cytokine. 2013 Apr;62(1):165-73
pubmed: 23523008
JAMA. 2012 Jun 20;307(23):2526-33
pubmed: 22797452
Lancet. 2020 Feb 29;395(10225):709-733
pubmed: 32061315
Thromb Haemost. 2009 Sep;102(3):511-9
pubmed: 19718472
J Cardiovasc Med (Hagerstown). 2015 Jan;16(1):37-44
pubmed: 24933198
Am J Kidney Dis. 2008 Apr;51(4):603-12
pubmed: 18371536
Crit Care. 2019 Jan 17;23(1):16
pubmed: 30654825
Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1703-9
pubmed: 21512165
Blood. 2019 Aug 29;134(9):776-781
pubmed: 31243040
Curr Treat Options Neurol. 2019 Jul 20;21(8):40
pubmed: 31327064
Basic Res Cardiol. 2008 Sep;103(5):398-406
pubmed: 18600364
J Am Coll Cardiol. 2020 Oct 6;76(14):1690-1702
pubmed: 33004135
Circ Res. 2019 Mar 29;124(7):1094-1112
pubmed: 30920918
Obes Rev. 2009 Sep;10(5):554-63
pubmed: 19460118
J Affect Disord. 2014 Apr;159:39-45
pubmed: 24679387
Eur J Haematol. 2000 Oct;65(4):215-20
pubmed: 11073162
Circ Res. 2007 Feb 2;100(2):174-90
pubmed: 17272819
Cardiovasc Res. 2018 Nov 1;114(13):1752-1763
pubmed: 29939250
J Pharmacol Exp Ther. 2003 Jul;306(1):103-8
pubmed: 12660308
BMJ. 2019 Jul 15;366:l2381
pubmed: 31307997
J Am Coll Surg. 2020 Aug;231(2):193-203.e1
pubmed: 32422349
Hypertension. 2016 Jun;67(6):1072-9
pubmed: 27067718
Am J Nephrol. 2010;31(5):435-41
pubmed: 20389059
Biol Blood Marrow Transplant. 2009 May;15(5):537-46
pubmed: 19361745
Cancer Discov. 2017 Dec;7(12):1371-1373
pubmed: 29208775
Int J Mol Sci. 2019 Jul 02;20(13):
pubmed: 31269775
Front Immunol. 2023 Apr 04;14:1144229
pubmed: 37081895
Int J Mol Sci. 2021 Apr 26;22(9):
pubmed: 33926110
Diabetes. 2010 Dec;59(12):3008-16
pubmed: 20841607
Bone Marrow Transplant. 2021 Mar;56(3):570-580
pubmed: 32943758
J Thromb Thrombolysis. 2003 Aug-Oct;16(1-2):43-7
pubmed: 14760211
Hypertension. 2018 Jul;72(1):24-43
pubmed: 29899139
Compr Physiol. 2015 Apr;5(2):531-59
pubmed: 25880504
Blood Adv. 2021 Sep 14;5(17):3397-3406
pubmed: 34432870
Bone Marrow Transplant. 2021 Jul;56(7):1651-1664
pubmed: 33623153
Blood. 2015 Jun 18;125(25):3905-16
pubmed: 25940712
Clin Kidney J. 2019 Jun 17;13(1):72-74
pubmed: 32082555
Clin J Am Soc Nephrol. 2008 Mar;3(2):505-21
pubmed: 18184879
J Cell Sci. 2005 Feb 1;118(Pt 3):623-32
pubmed: 15657074
Immunol Rev. 2007 Aug;218:178-96
pubmed: 17624953
Cancer Discov. 2017 Dec;7(12):1404-1419
pubmed: 29025771
Best Pract Res Clin Anaesthesiol. 2014 Sep;28(3):227-34
pubmed: 25208958
Crit Care. 2010;14(5):R182
pubmed: 20942957
Lab Chip. 2020 Mar 17;20(6):1153-1166
pubmed: 32100769
Lab Invest. 1999 Feb;79(2):213-23
pubmed: 10068209
Curr Opin Physiol. 2023 Aug;34:100670
pubmed: 37159613
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):729-36
pubmed: 12615672
Bone Marrow Transplant. 1991 Dec;8(6):497-502
pubmed: 1790430
Virulence. 2013 Aug 15;4(6):556-63
pubmed: 23955166
Cardiovasc Res. 2021 Jan 1;117(1):60-73
pubmed: 32215570
Cancer Discov. 2018 Aug;8(8):958-971
pubmed: 29880584
J Cell Mol Med. 2020 Jul;24(14):8031-8044
pubmed: 32519822
Cold Spring Harb Perspect Med. 2023 Aug 1;13(8):
pubmed: 37460157
Lancet Haematol. 2017 Sep;4(9):e414-e423
pubmed: 28733186
Pharmacol Rep. 2008 Jan-Feb;60(1):139-43
pubmed: 18276995
Lancet. 2013 Jul 20;382(9888):260-72
pubmed: 23727169
Curr Hematol Rep. 2005 Sep;4(5):359-67
pubmed: 16131436
Int J Biol Sci. 2013 Nov 09;9(10):1057-69
pubmed: 24250251
Clin Hematol Int. 2019 Mar 18;1(1):45-51
pubmed: 34595410
Clin Nephrol. 2022 May;97(5):261-272
pubmed: 34931610
Thromb Res. 1999 Jul 1;95(1):1-18
pubmed: 10403682
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Cardiovasc Drugs Ther. 2022 Jun;36(3):547-560
pubmed: 34097193
Bone Marrow Transplant. 2015 Jan;50(1):113-20
pubmed: 25243628
Angiogenesis. 2023 Apr 27;:
pubmed: 37103631
CMAJ. 2017 Jan 30;189(4):E153-E159
pubmed: 27754896
Vitam Horm. 2006;74:443-77
pubmed: 17027526
Blood. 2016 Jun 30;127(26):3321-30
pubmed: 27207799
Am J Obstet Gynecol. 2022 Feb;226(2S):S1019-S1034
pubmed: 33096092
Br J Haematol. 2020 Aug;190(4):508-519
pubmed: 32319084
Eur J Clin Invest. 2015 Feb;45(2):160-9
pubmed: 25496217
Blood. 1998 May 15;91(10):3527-61
pubmed: 9572988
Front Immunol. 2020 Aug 18;11:1864
pubmed: 33013837
Leuk Res. 2017 Apr;55:49-54
pubmed: 28122283
PLoS One. 2016 Feb 05;11(2):e0148142
pubmed: 26849138
Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E656-65
pubmed: 17578888
Cells. 2019 May 17;8(5):
pubmed: 31108880
Placenta. 2014 Feb;35 Suppl:S20-5
pubmed: 24477207
Front Immunol. 2017 Mar 20;8:79
pubmed: 28373870
Kidney Int. 2013 Oct;84(4):733-44
pubmed: 23636172
Front Cardiovasc Med. 2023 May 16;10:1162837
pubmed: 37260945
Lancet Respir Med. 2022 Dec;10(12):1178-1188
pubmed: 36335956
Kidney Int. 2019 Jun;95(6):1298-1300
pubmed: 31122707
Ultrasound Obstet Gynecol. 2019 Nov;54(5):609-616
pubmed: 31115105
J Clin Invest. 2011 Feb;121(2):593-603
pubmed: 21266777
Blood Rev. 2019 Mar;34:45-55
pubmed: 30528964
Haematologica. 2002 Oct;87(10):1053-61
pubmed: 12368160