The role of the fracture liaison service in the prevention of atypical femoral fractures.

atypical femoral fractures bisphosphonate drug holiday fracture liaison service fragility fractures prevention

Journal

Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322

Informations de publication

Date de publication:
2023
Historique:
received: 16 03 2023
accepted: 29 09 2023
medline: 30 11 2023
pubmed: 30 11 2023
entrez: 30 11 2023
Statut: epublish

Résumé

Osteoporosis and fragility fractures (FFs) are considered critical health problems by the World Health Organization (WHO) because of high morbidity, mortality, and healthcare costs. The occurrence of a FF raises the risk of a subsequent fracture (refracture). The hip is the most common site of fragility refracture, and its onset is associated with a further increase in patient's morbidity, mortality, and socioeconomic burden. Therefore, the prevention of refracture is essential. In this context, fracture liaison service (FLS) demonstrated to be able to reduce FF risk and also improve patients' adherence to anti-osteoporotic treatments, particularly for bisphosphonates (BPs). However, long-term and high adherence to BPs may lead to atypical femoral fractures (AFFs). These latter are tensile side stress fractures of the femur, with high rates of complications, including delayed and non-healing. An effective FLS should be able to prevent both FF and AFF. A comprehensive and interdisciplinary approach, through the involvement and education of a dedicated team of healthcare professionals (i.e. orthopedic, geriatrician, primary care physician, rehabilitation team, and bone nurse) for evaluating both FF and AFF risks might be useful to improve the standard of care.

Identifiants

pubmed: 38035253
doi: 10.1177/1759720X231212747
pii: 10.1177_1759720X231212747
pmc: PMC10685792
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1759720X231212747

Informations de copyright

© The Author(s), 2023.

Déclaration de conflit d'intérêts

UT serves on the Advisory Board for Abiogen, AMGEN, and Eli-Lilly. GI serves on the Advisory Board for UCB Pharma, AMGEN, and Eli-Lilly. The other authors declare that there is no conflict of interest.

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Auteurs

Giuseppe Toro (G)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 4, Naples 80138, Italy.

Adriano Braile (A)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Unit of Orthopaedics and Traumatology, Ospedale del Mare, Naples, Italy.

Sara Liguori (S)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Antimo Moretti (A)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Giovanni Landi (G)

Unit of Orthopaedics and Traumatology, Santa Maria della Speranza Hospital, Battipaglia, Italy.

Antonio Benedetto Cecere (AB)

Unit of Orthopaedics and Traumatology, San Giuliano Hospital, Giugliano, Italy.

Gianluca Conza (G)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Annalisa De Cicco (A)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Unit of Orthopaedics and Traumatology, Santa Maria delle Grazie Hospital, Pozzuoli, Italy.

Umberto Tarantino (U)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.

Giovanni Iolascon (G)

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Classifications MeSH