Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
30 Nov 2023
30 Nov 2023
Historique:
received:
03
11
2022
accepted:
16
10
2023
medline:
1
12
2023
pubmed:
1
12
2023
entrez:
30
11
2023
Statut:
aheadofprint
Résumé
Experimental work across species has demonstrated that spontaneously generated behaviors are robustly coupled to variations in neural activity within the cerebral cortex. Functional magnetic resonance imaging data suggest that temporal correlations in cortical networks vary across distinct behavioral states, providing for the dynamic reorganization of patterned activity. However, these data generally lack the temporal resolution to establish links between cortical signals and the continuously varying fluctuations in spontaneous behavior observed in awake animals. Here, we used wide-field mesoscopic calcium imaging to monitor cortical dynamics in awake mice and developed an approach to quantify rapidly time-varying functional connectivity. We show that spontaneous behaviors are represented by fast changes in both the magnitude and correlational structure of cortical network activity. Combining mesoscopic imaging with simultaneous cellular-resolution two-photon microscopy demonstrated that correlations among neighboring neurons and between local and large-scale networks also encode behavior. Finally, the dynamic functional connectivity of mesoscale signals revealed subnetworks not predicted by traditional anatomical atlas-based parcellation of the cortex. These results provide new insights into how behavioral information is represented across the neocortex and demonstrate an analytical framework for investigating time-varying functional connectivity in neural networks.
Identifiants
pubmed: 38036743
doi: 10.1038/s41593-023-01498-y
pii: 10.1038/s41593-023-01498-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH099045
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH121841
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH113852
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : EY033975
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : EY022951
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : EY029581
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : EY031133
Organisme : U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI)
ID : EY026878
Organisme : U.S. Department of Health && Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : EB026936
Organisme : National Science Foundation (NSF)
ID : CCF-2217058
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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