Phytosterols: Potential Therapeutic Effects and Challenges in Food Industry.
Bioavailability
Fortification in food matrices
Human health
Phytosterols
Therapeutic effects
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
4
12
2023
pubmed:
1
12
2023
entrez:
30
11
2023
Statut:
ppublish
Résumé
Increases in serum total and low-density lipoprotein (LDL) cholesterol are known as hypercholesterolemia, and it is a significant risk factor for the emergence of cardiovascular illnesses. Any action strategy for lowering serum cholesterol is supported by lifestyle changes. Phytosterols are organic substances from the triterpene family. Phytosterols can lower serum LDL cholesterol levels because of their structural resemblance to cholesterol. Phytosterols are used to enrich or fortify a broad spectrum of food products. Phytosterols are quickly oxidized, just like cholesterol and unsaturated fatty acids. The utilization of free phytosterols for the manufacture of functional meals is highlighted in this chapter, which also focuses on the therapeutic effects of phytosterols and their technological concerns in the industrial field.
Identifiants
pubmed: 38036893
doi: 10.1007/978-3-031-43883-7_22
doi:
Substances chimiques
Phytosterols
0
Cholesterol, LDL
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
453-462Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Abdelkrim YZ, Harigua-Souiai E, Bassoumi-Jamoussi I, Barhoumi M, Banroques J, Essafi-Benkhadir K, Nilges M, Blondel A, Tanner NK, Guizani I (2022) Enzymatic and molecular characterization of anti-leishmania molecules that differently target leishmania and mammalian eIF4A proteins, LieIF4A and eIF4AMus. Molecules 27:5890
pubmed: 36144626
pmcid: 9502374
doi: 10.3390/molecules27185890
Alvarez-Sala A, Garcia-Llatas G, Cilla A, Barbera R, Sanchez-Siles LM, Lagarda MJ (2016) Impact of lipid components and emulsifiers on plant sterols bioaccessibility from milk-based fruit beverages. J Agric Food Chem 64:5686–5691
pubmed: 27329567
doi: 10.1021/acs.jafc.6b02028
Amal AMN, Mahmoud AM, Zidan NS (2016) Fruit Flavored Yoghurt: chemical, functional and rheological properties
Babu S, Jayaraman S (2020) An update on β-sitosterol: a potential herbal nutraceutical for diabetic management. Biomed Pharmacother 131:110702
pubmed: 32882583
doi: 10.1016/j.biopha.2020.110702
Bao L, Li Y, Deng SX, Landry D, Tabas I (2006) Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages. J Biol Chem 281:33635–33649
pubmed: 16935859
doi: 10.1074/jbc.M606339200
Bazin MA, Loiseau PM, Bories C, Letourneux Y, Rault S, El Kihel L (2006) Synthesis of oxysterols and nitrogenous sterols with antileishmanial and trypanocidal activities. Eur J Med Chem 41:1109–1116
pubmed: 16949702
doi: 10.1016/j.ejmech.2006.03.033
Borel P (2003) Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols). Clin Chem Lab Med 41:979–994
pubmed: 12964802
doi: 10.1515/CCLM.2003.151
Botelho PB, Galasso M, Dias V, Mandrioli M, Lobato LP, Rodriguez-Estrada MT, Castro IA (2014) Oxidative stability of functional phytosterol-enriched dark chocolate. LWT Food Sci Technol 55:444–451
doi: 10.1016/j.lwt.2013.09.002
Citta A, Folda A, Scalcon V, Scutari G, Bindoli A, Bellamio M, Feller E, Rigobello MP (2017) Oxidative changes in lipids, proteins, and antioxidants in yogurt during the shelf life. Food Sci Nutr 5:1079–1087
pubmed: 29188035
pmcid: 5694872
doi: 10.1002/fsn3.493
Corrêa RCG, Peralta RM, Bracht A, Ferreira ICFR (2017) The emerging use of mycosterols in food industry along with the current trend of extended use of bioactive phytosterols. Trends Food Sci Technol 67:19–35
doi: 10.1016/j.tifs.2017.06.012
Demonty I, Ras RT, Van Der Knaap HC, Duchateau GS, Meijer L, Zock PL, Geleijnse JM, Trautwein EA (2009) Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. J Nutr 139:271–284
pubmed: 19091798
doi: 10.3945/jn.108.095125
Fahy DM, O’Callaghan YC, O’Brien NM (2004) Phytosterols: lack of cytotoxicity but interference with beta-carotene uptake in Caco-2 cells in culture. Food Addit Contam 21:42–51
pubmed: 14744679
doi: 10.1080/02652030310001636921
Genser B, Silbernagel G, De Backer G, Bruckert E, Carmena R, Chapman MJ, Deanfield J, Descamps OS, Rietzschel ER, Dias KC, März W (2012) Plant sterols and cardiovascular disease: a systematic review and meta-analysis. Eur Heart J 33:444–451
pubmed: 22334625
pmcid: 3279314
doi: 10.1093/eurheartj/ehr441
Ghosh P, Ghosh A, Mandal A, Sultana SS, Dey S, Pal C (2016) Oxysterols: synthesis and anti-leishmanial activities. Steroids 107:65–73
pubmed: 26742629
doi: 10.1016/j.steroids.2015.12.020
Gonzalez-Larena M, Cilla A, Garcia-Llatas G, Barbera R, Lagarda MJ (2012) Plant sterols and antioxidant parameters in enriched beverages: storage stability. J Agric Food Chem 60:4725–4734
pubmed: 22509888
doi: 10.1021/jf3002679
Gray J, Armstrong G, Farley H (2003) Opportunities and constraints in the functional food market. Nutr Food Sci 33:213–218
doi: 10.1108/00346650310499730
Gylling H, Plat J, Turley S, Ginsberg HN, Ellegård L, Jessup W, Jones PJ, Lütjohann D, Maerz W, Masana L, Silbernagel G, Staels B, Borén J, Catapano AL, De Backer G, Deanfield J, Descamps OS, Kovanen PT, Riccardi G, Tokgözoglu L, Chapman MJ (2014) Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis 232:346–360
pubmed: 24468148
doi: 10.1016/j.atherosclerosis.2013.11.043
Hasler CM (1998) Functional foods: their role in disease prevention and health promotion. Food Technol 52:63–70
Helal A, Rashid NN, Noha E, Dyab, Al-Otaibi M, Tareq M, Alnemr (2018) Enhanced functional, sensory, microbial and texture properties of low-fat set yogurt supplemented with high-density inulin. J Food Process Beverages
Ho SS, Pal S (2005) Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. Atherosclerosis 182:29–36
pubmed: 16115472
doi: 10.1016/j.atherosclerosis.2005.01.031
Huang J, Xu M, Fang YJ, Lu MS, Pan ZZ, Huang WQ, Chen YM, Zhang CX (2017) Association between phytosterol intake and colorectal cancer risk: a case-control study. Br J Nutr 117:839–850
pubmed: 28382872
doi: 10.1017/S0007114517000617
Izadi Z, Nasirpour A, Garoosi GA, Tamjidi F (2015) Rheological and physical properties of yogurt enriched with phytosterol during storage. J Food Sci Technol 52:5341–5346
pubmed: 26243963
doi: 10.1007/s13197-014-1593-2
Jesch ED, Carr TP (2017) Food ingredients that inhibit cholesterol absorption. Prev Nutr Food Sci 22:67–80
pubmed: 28702423
pmcid: 5503415
Jiang L, Zhao X, Xu J, Li C, Yu Y, Wang W, Zhu L (2019) The protective effect of dietary phytosterols on cancer risk: a systematic meta-analysis. J Oncol 2019:7479518
pubmed: 31341477
pmcid: 6612402
doi: 10.1155/2019/7479518
Jones PJH, Shamloo M, Mackay DS, Rideout TC, Myrie SB, Plat J, Roullet JB, Baer DJ, Calkins KL, Davis HR, Barton Duell P, Ginsberg H, Gylling H, Jenkins D, Lütjohann D, Moghadasian M, Moreau RA, Mymin D, Ostlund RE Jr, Ras RT, Ochoa Reparaz J, Trautwein EA, Turley S, Vanmierlo T, Weingärtner O (2018) Progress and perspectives in plant sterol and plant stanol research. Nutr Rev 76:725–746
pubmed: 30101294
pmcid: 6130982
doi: 10.1093/nutrit/nuy032
Li X, Xin Y, Mo Y, Marozik P, He T, Guo H (2022) The bioavailability and biological activities of phytosterols as modulators of cholesterol metabolism. Molecules 27:523
pubmed: 35056839
pmcid: 8781140
doi: 10.3390/molecules27020523
Lucey JA, Singh H (1997) Formation and physical properties of acid milk gels: a review. Food Res Int 30:529–542
doi: 10.1016/S0963-9969(98)00015-5
Lye H-S, Rahmat-Ali GR, Liong M-T (2010) Mechanisms of cholesterol removal by lactobacilli under conditions that mimic the human gastrointestinal tract. Int Dairy J 20:169–175
doi: 10.1016/j.idairyj.2009.10.003
Majid Shah S, Ullah F, Ayaz M, Sadiq A, Hussain S, Ali Shah AU, Adnan Ali Shah S, Wadood A, Nadhman A (2019) β-Sitosterol from Ifloga spicata (Forssk.) Sch. Bip. as potential anti-leishmanial agent against leishmania tropica: docking and molecular insights. Steroids 148:56–62
pubmed: 31085212
doi: 10.1016/j.steroids.2019.05.001
Makhmudova U, Schulze PC, Lütjohann D, Weingärtner O (2021) Phytosterols and cardiovascular disease. Curr Atheroscler Rep 23:68
pubmed: 34468867
pmcid: 8410723
doi: 10.1007/s11883-021-00964-x
Mandlik Ingawale DS, Namdeo AG (2021) Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. J Diet Suppl 18:183–226
pubmed: 32242751
doi: 10.1080/19390211.2020.1741484
Merah O, Mouloungui Z (2019) Tetraploid wheats: valuable source of phytosterols and phytostanols. Agronomy 9:201
doi: 10.3390/agronomy9040201
Monu E, Blank G, Holley R, Zawistowski J (2008) Phytosterol effects on milk and yogurt microflora. J Food Sci 73:M121–M126
pubmed: 18387114
doi: 10.1111/j.1750-3841.2008.00668.x
Moreau RA (2015) Composition of plant sterols and stanols in supplemented food products. J AOAC Int 98:685–690
pubmed: 25942633
doi: 10.5740/jaoacint.SGEMoreau
Olfa BM, Marwa M, Moncef C, Mouna B, Mnasser H (2019) The combined effect of phytosterols and lactulose supplementation on yoghurt quality. J Food Nutr Res 7:261–269
Oshadi J, Sumali F, Vijith J, Deepika H (2015) Production of a novel fruit-yoghurt using dragon fruit (Hylocereus Undatus L.). Eur Sci J (ESJ), 11
Poli A, Marangoni F, Corsini A, Manzato E, Marrocco W, Martini D, Medea G, Visioli F (2021) Phytosterols, cholesterol control, and cardiovascular disease. Nutrients 13:2810
pubmed: 34444970
pmcid: 8399210
doi: 10.3390/nu13082810
Racette SB, Lin X, Lefevre M, Spearie CA, Most MM, Ma L, Ostlund RE Jr (2010) Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr 91:32–38
pubmed: 19889819
doi: 10.3945/ajcn.2009.28070
Rezig L, Ghzaiel I, Ksila M, Yammine A, Nury T, Zarrouk A, Samadi M, Chouaibi M, Vejux A, Lizard G (2022) Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol-and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases Steroids 109093
Rudzinska M, Przybylski R, Wasowicz E (2014) Degradation of phytosterols during storage of enriched margarines. Food Chem 142:294–298
pubmed: 24001844
doi: 10.1016/j.foodchem.2013.07.041
Semeniuc CA, Cardenia V, Mandrioli M, Muste S, Borsari A, Rodriguez-Estrada MT (2016) Stability of flavoured phytosterol-enriched drinking yogurts during storage as affected by different packaging materials. J Sci Food Agric 96:2782–2787
pubmed: 26332790
doi: 10.1002/jsfa.7443
Serra M, Trujillo AJ, Pereda J, Guamis B, Ferragut V (2008) Quantification of lipolysis and lipid oxidation during cold storage of yogurts produced from milk treated by ultra-high pressure homogenization. J Food Eng 89:99–104
doi: 10.1016/j.jfoodeng.2008.04.010
Sharmila R, Sindhu G (2017) Evaluate the antigenotoxicity and anticancer role of β-sitosterol by determining oxidative DNA damage and the expression of phosphorylated mitogen-activated protein kinases’, C-fos, C-Jun, and endothelial growth factor receptor. Pharmacogn Mag 13:95–101
pubmed: 28216890
pmcid: 5307922
Tolve R, Cela N, Condelli N, Di Cairano M, Caruso MC, Galgano F (2020) Microencapsulation as a tool for the formulation of functional foods: the phytosterols’ case study. Foods 9:470
pubmed: 32283860
pmcid: 7230576
doi: 10.3390/foods9040470
Vaghini S, Cilla A, Garcia-Llatas G, Lagarda MJ (2016) Bioaccessibility study of plant sterol-enriched fermented milks. Food Funct 7:110–117
pubmed: 26447847
doi: 10.1039/C5FO00458F
WHO (2021) Cardiovascular diseases (CVDs). https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) . Accessed 12 May 2023