Regional outcome disparities in German head and neck cancer patients: Shorter survival in Eastern Germany.
age
cancer registry data
demographic change
socioeconomic health disparity
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
16
10
2023
accepted:
27
10
2023
medline:
1
12
2023
pubmed:
1
12
2023
entrez:
1
12
2023
Statut:
aheadofprint
Résumé
Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in head and neck cancer (HNC) patients (HNCP) has not been performed previously. A retrospective analysis of data from the Center for Cancer Registry Data (ZfKD) and the Federal Statistical Office (Destatis) between 2002 and 2017 was performed. A total of 212'920 HNCP were included. Incidence, tumor stage, age development, sex distribution, age-, residence-, and diagnosis-time-specific survival were examined. Mean age of HNCP increased more rapidly than in the general population (slope coefficient: 0.29 vs. 0.20; p < 0.0001). Higher age and male sex were associated with a worse prognosis. Whereas overall survival (OS) increased from the early to the later observation period for HNCP <70 years, no OS improvement for HNCP >70 years was found. Furthermore, an OS disadvantage was observed for East Germany compared to West Germany (median 47 vs. 60 months; p < 0.0001). This disparity was associated with a disproportionately high ratio of men in East Germany (men/women: 4.4 vs. 3.1; p < 0.0001) and a lower mean age (61 vs. 63 years; p < 0.0001). In addition to stage, age and sex, residence in East Germany were confirmed as an independent factor for OS in a multivariate analysis. Finally, three decades after the German reunion, a survival disadvantage for patients in East Germany still exists. This discrepancy may be a result of socioeconomic disparities.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Références
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249.
Miranda-Galvis M, Loveless R, Kowalski LP, Teng Y. Impacts of environmental factors on head and neck cancer pathogenesis and progression. Cell. 2021;10(2):389.
Du E, Mazul AL, Farquhar D, et al. Long-term survival in head and neck cancer: impact of site, stage, smoking, and human papillomavirus status. Laryngoscope. 2019;129(11):2506-2513.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6(1):92.
Anisimov VN. Biology of aging and cancer. Cancer Control. 2007;14(1):23-31.
Fazel A, Quabius ES, Fabian A, et al. The impact of smoking habit alteration on prognosis of head and neck cancer patients. Laryngorhinootologie. 2021;100(8):634-643.
Tinhofer I, Jöhrens K, Keilholz U, et al. Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence. Eur J Cancer. 2015;51(4):514-521.
Nowossadeck E. Population aging and hospitalization for chronic disease in Germany. Dtsch Arztebl Int. 2012;109(9):151.
Mountzios G. Optimal management of the elderly patient with head and neck cancer: issues regarding surgery, irradiation and chemotherapy. World J Clin Oncol. 2015;6(1):7-15.
Vahl JM, Wigand MC, Denkinger M, et al. Increasing mean age of head and neck cancer patients at a German tertiary referral center. Cancers (Basel). 2021;13(4):832.
Dittberner A, Friedl B, Wittig A, et al. Gender disparities in epidemiology, treatment, and outcome for head and neck cancer in Germany: a population-based long-term analysis from 1996 to 2016 of the Thuringian cancer registry. Cancers (Basel). 2020;12(11):3418.
Woods LM, Rachet B, Coleman MP. Origins of socio-economic inequalities in cancer survival: a review. Ann Oncol. 2006;17(1):5-19.
Wienecke A, Kraywinkel K. Epidemiologie von Kopf-Hals-Tumoren in Deutschland. Der Onkologe. 2019;25(3):190-200.
Bayer O, Krüger M, Koutsimpelas D, et al. Veränderung von Inzidenz und Mortalität von Kopf-Hals-Malignomen in Rheinland-Pfalz, 2000-2009. Laryngorhinootologie. 2015;94(7):451-458.
Guntinas-Lichius O, Wendt T, Buentzel J, et al. Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database. J Cancer Res Clin Oncol. 2010;136(1):55-63.
Zentrum für Krebsregisterdaten (ZfKD) im Robert Koch-Institut. Datensatz des ZfKD auf Basis der epidemiologischen Landeskrebsregisterdaten, verfügbare Diagnosejahre Bis 2017. 2020. Epi2019_2. 2020.
Cline BJ, Simpson MC, Gropler M, et al. Change in age at diagnosis of oropharyngeal cancer in the United States, 1975-2016. Cancer. 2020;12(11):3191.
Hashim D, Carioli G, Malvezzi M, et al. Cancer mortality in the oldest old: a global overview. Aging (Albany NY). 2020;12(17):16744-16758.
Gollnitz I, Inhestern J, Wendt TG, et al. Role of comorbidity on outcome of head and neck cancer: a population-based study in Thuringia, Germany. Cancer Med. 2016;5(11):3260-3271.
Kouka M, Buentzel J, Kaftan H, et al. Early mortality among patients with head and neck cancer diagnosed in Thuringia, Germany, between 1996 and 2016-a population-based study. Cancers (Basel). 2022;14(13):3099.
Goldstein DP, Sklar MC, de Almeida JR, et al. Frailty as a predictor of outcomes in patients undergoing head and neck cancer surgery. Laryngoscope. 2020;130(5):E340-E345.
Li D, Sun C-L, Kim H, et al. Geriatric assessment-driven intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial. JAMA Oncol. 2021;7(11):e214158.
Mohile SG, Mohamed MR, Xu H, et al. Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study. Lancet. 2021;398(10314):1894-1904.
Richter M, Pförtner T-K, Lampert T. Veränderungen im Tabak-, Alkohol-und Cannabiskonsum von Jugendlichen im Zeitraum von 2002 bis 2010 in Deutschland. DasGesundheitswesen. 2012;74(S 01):S42-S48.
Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091-2098.
Forastiere AA, Zhang Q, Weber RS, et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013;31(7):845-852.
Vermorken JB, Stohlmacher-Williams J, Davidenko I, et al. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial. Lancet Oncol. 2013;14(8):697-710.
Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567-578.
Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937-1944.
Bernier J, Cooper JS, Pajak TF, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27(10):843-850.
Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350(19):1945-1952.
Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359(11):1116-1127.
Pignon JP, le Maitre A, Maillard E, Bourhis J. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009;92(1):4-14.
Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11(1):21-28.
White MC, Holman DM, Boehm JE, Peipins LA, Grossman M, Henley SJ. Age and cancer risk: a potentially modifiable relationship. Am J Prev Med. 2014;46(3 Suppl 1):S7-S15.
Derks W, De Leeuw J, Hordijk G, Winnubst J. Reasons for non-standard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol. 2005;262(1):21-26.
Baggio G, Corsini A, Floreani A, Giannini S, Zagonel V. Gender medicine: a task for the third millennium. Clin Chem Lab Med. 2013;51(4):713-727.
Takla A, Wiese-Posselt M, Harder T, et al. Background paper for the recommendation of HPV vaccination for boys in Germany. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz. 2018;61(9):1170-1186.
Razum O, Altenhöner T, Breckenkamp J, Voigtländer S. Social epidemiology after the German reunification: East vs. West or poor vs. rich? Int J Public Health. 2008;53(1):13-22.
Vogt TC. How many years of life did the fall of the Berlin Wall add? A projection of East German life expectancy. Gerontology. 2013;59(3):276-282.
Wenau G, Grigoriev P, Shkolnikov V. Socioeconomic disparities in life expectancy gains among retired German men, 1997-2016. J Epidemiol Community Health. 2019;73(7):605-611.
Mielck A, Helmert U. Soziale Ungleichheit und Gesundheit: na. 2000.
Hurst JW. Reform of health care in Germany. Health Care Financ Rev. 1991;12(3):73.
Redonnet B, Chollet A, Fombonne E, Bowes L, Melchior M. Tobacco, alcohol, cannabis and other illegal drug use among young adults: the socioeconomic context. Drug Alcohol Depend. 2012;121(3):231-239.
Goodwin WJ, Thomas GR, Parker DF, et al. Unequal burden of head and neck cancer in the United States. Head Neck. 2008;30(3):358-371.
Vahl JM, von Witzleben A, Welke C, et al. Influence of travel burden on tumor classification and survival of head and neck cancer patients. European archives of Oto-rhino-laryngology. Eur Arch Otorhinolaryngol. 2021;278(11):4535-4543.
BIB. Regionale Unterschiede in der Bevölkerungsentwicklung: Bundesinstitut für Bevölkerungsforschung. 2022. Available from: https://www.bib.bund.de/DE/Fakten/Regional/Bevoelkerungsentwicklung.html.
Staab A. Xenophobia, ethnicity and national identity in eastern Germany. German Politics. 1998;7(2):31-46.
Bambra C. Levelling up: global examples of reducing health inequalities. Scand J Public Health. 2021;50:908-913.
Vahl JM, Nagel G, Grages A, et al. Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany. Cancer Med. 2023;12:18826-18836.
Gurung-Schönfeld I, Kraywinkel K. Krebsregistrierung heute: zwischen Epidemiologie. Qualitätssicherung Und Forschung. 2021;4:3-9.
dos Santos MF, Fernandes GA, Antunes JLF, Villa LL, Toporcov TN. Global incidence trends in head and neck cancer for HPV-related and-unrelated subsites: a systematic review of population-based studies. Oral Oncol. 2021;115:105177.