The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer.

Chi3l1 NETosis T cell stromal restriction TNBC breast cancer immune microenvironment immunotherapy mouse models neutrophils

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
12 Dec 2023
Historique:
received: 23 03 2023
revised: 22 09 2023
accepted: 05 11 2023
pubmed: 2 12 2023
medline: 2 12 2023
entrez: 1 12 2023
Statut: ppublish

Résumé

In triple-negative breast cancer (TNBC), stromal restriction of CD8

Identifiants

DOI: 10.1016/j.immuni.2023.11.002 PMID: 38039967
pubmed: 38039967
pii: S1074-7613(23)00483-1
doi: 10.1016/j.immuni.2023.11.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2755-2772.e8

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests J.A.E. is a co-founder of Elkurt Therapeutics and is a founder of and stockholder in and serves on the Scientific Advisory Board for Ocean Biomedical Inc., which develops inhibitors of 18-glycosyl hydrolases as therapeutics. C.G.L. and S.K. are consultants for Ocean Biomedical Inc. J.A.E., C.G.L., and S.K. have a patent entitled “methods and composition relating to anti-CHI3L1 antibody reagents” (US Patent 10253111).

Auteurs

Tarek Taifour (T)

McGill University, Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, Montreal, QC H4A 3J1, Canada; Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Sherif Samer Attalla (SS)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; McGill University, Department of Biochemistry, Faculty of Medicine, Montreal, QC H3A 1A3, Canada.

Dongmei Zuo (D)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Yu Gu (Y)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; McGill University, Department of Biochemistry, Faculty of Medicine, Montreal, QC H3A 1A3, Canada.

Virginie Sanguin-Gendreau (V)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Hailey Proud (H)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; McGill University, Department of Biochemistry, Faculty of Medicine, Montreal, QC H3A 1A3, Canada.

Emilie Solymoss (E)

McGill University, Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, Montreal, QC H4A 3J1, Canada; Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Tung Bui (T)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Hellen Kuasne (H)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Vasilios Papavasiliou (V)

Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada.

Chun Geun Lee (CG)

Brown University, Molecular Biology and Immunology, Faculty of Medicine, Providence, RI 02903, USA.

Suchitra Kamle (S)

Brown University, Molecular Biology and Immunology, Faculty of Medicine, Providence, RI 02903, USA.

Peter M Siegel (PM)

McGill University, Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, Montreal, QC H4A 3J1, Canada; Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; McGill University, Department of Biochemistry, Faculty of Medicine, Montreal, QC H3A 1A3, Canada.

Jack A Elias (JA)

Brown University, Molecular Biology and Immunology, Faculty of Medicine, Providence, RI 02903, USA.

Morag Park (M)

McGill University, Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, Montreal, QC H4A 3J1, Canada; Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; McGill University, Department of Biochemistry, Faculty of Medicine, Montreal, QC H3A 1A3, Canada.

William J Muller (WJ)

McGill University, Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, Montreal, QC H4A 3J1, Canada; Goodman Cancer Institute, Montreal, QC H3A 1A3, Canada; McGill University, Department of Biochemistry, Faculty of Medicine, Montreal, QC H3A 1A3, Canada. Electronic address: william.muller@mcgill.ca.

Classifications MeSH