Standardized and simplified reporting of next-generation sequencing results in advanced non-small-cell lung cancer: practical indications from an Italian multidisciplinary group.

Molecular biomarker testing is increasingly becoming standard of care for advanced non-small cell lung cancer (NSCLC). Tissue and liquid biopsy-based next-generation sequencing (NGS) is now highly recommended and has become an integral part of the routine management of advanced NSCLC patients. This highly sensitive approach can simultaneously and efficiently detect multiple biomarkers even in scant samples. However full optimization of NGS in clinical practice requires accurate reporting and interpretation of NGS findings. Indeed, as the number of NSCLC biomarkers continues to grow, clinical reporting of NGS data is becoming increasingly complex. In this scenario, achieving standardization, simplification, and improved readability of NGS reports is key to ensuring timely and appropriate treatment decisions. In an effort to address the complexity and lengthy reporting of NGS mutation results, an Italian group of 14 healthcare professionals involved in NSCLC management convened in 2023 to address the content, structure, and ease-of-use of NGS reporting practices and proposed a standard report template for clinical use This article presents the key discussion points addressed by the Italian working group and describes the essential elements of the report template.

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Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Umberto Malapelle has received personal fees (as consultant and/or speaker bureau) from Boehringer Ingelheim, Roche, MSD, Amgen, Thermo Fisher Scientific, Eli Lilly, Diaceutics, GSK, Merck and AstraZeneca, Janssen, Diatech, Novartis and Hedera unrelated to the current work. Fabio Pagni received personal fees (as consultant and/or speaker bureau) from, MSD, GSK, Merck and AstraZeneca, unrelated to the current work. Elena Guerini Rocco has relevant relationship (advisory fees, honoraria, travel accommodation and expenses, grants and non-financial support) with AstraZeneca, Exact Sciences, GlaxoSmithKline (GSK), Novartis, Roche, Thermo Fisher Scientific unrelated to the current work. Giulia Pasello has received personal fees (as consultant and/or speaker bureau) from Amgen; Astrazeneca; BMS; Lilly; MSD; Roche; Jansenn Research support: Astrazeneca; Roche unrelated to the current work. Giuseppe Perrone has received personal fees (as consultant and/or speaker bureau) from AstraZeneca, Amgen, Boehringer Ingelheim, Daiichi-Sankyo, Diatech Pharmacogenomics, Eli Lilly, Incyte, GSK, Janssen, Merck Serono, MSD, Novartis, Roche unrelated to the current work. Francesco Pepe has received personal fees (as consultant and/or speaker bureau) from Menarini Stemline unrelated to the current work. Giancarlo Pruneri has received personal fees (as consultant and/or speaker bureau) from Lilly, Roche Foundation One, Bayer, Novartis unrelated to the current work. Giancarlo Troncone reports personal fees (as speaker bureau or advisor) from Roche, MSD, Pfizer and Bayer, unrelated to the current work. Silvia Novello reports personal fees (as speaker bureau or advisor) from Eli Lilly, MSD, Roche, BMS, Takeda, Pfizer, Astra Zeneca and Boehringer Ingelheim, unrelated to the current work. No relevant conflict of interest declared by Alessandro Delle Donne, Filippo Fraggetta, Simona Vatrano, Sandro Pignata, Carmine Pinto, Antonio Russo, Hector J Soto Parra, Stefania Vallone, Antonio Marchetti related to the current work.