Surfactant as a drug carrier.

Corticosteroids Drug delivery Lung injury Respiratory distress syndrome Surfactant

Journal

Seminars in fetal & neonatal medicine
ISSN: 1878-0946
Titre abrégé: Semin Fetal Neonatal Med
Pays: Netherlands
ID NLM: 101240003

Informations de publication

Date de publication:
Dec 2023
Historique:
pubmed: 2 12 2023
medline: 2 12 2023
entrez: 1 12 2023
Statut: ppublish

Résumé

Drug delivery using a surfactant vehicle has the potential to prevent systemic side effects by delivering therapeutic agents directly to the respiratory system. The inherent chemical properties of surfactant allows it to readily distribute throughout the respiratory system. Therapeutic agents delivered by surfactant can primarily confer additional benefits but have potential to improve surfactant function. It is critically important that additional agents do not interefere with the innate surface tension lowering function of surfactant. Systemic evaluation through benchtop, translational and human trials are required to translate this potential technique into clinical practice.

Identifiants

DOI: 10.1016/j.siny.2023.101499 PMID: 38040583
pubmed: 38040583
pii: S1744-165X(23)00075-6
doi: 10.1016/j.siny.2023.101499
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101499

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Arun Sett (A)

Newborn Research, The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Melbourne, Australia; Neonatal Research, Murdoch Children's Research Institute, Melbourne, Australia; Newborn Services, Joan Kirner Women's and Children's, Sunshine Hospital, Victoria, Australia. Electronic address: Arun.Sett@wh.org.au.

Charles C Roehr (CC)

Newborn Services, Southmead Hospital, North Bristol NHS Trust Bristol, Bristol, UK; Faculty of Health Sciences, University of Bristol, Bristol, UK; Oxford Population Health, National Perinatal Epidemiology Unit, Medical Sciences Division, University of Oxford, Oxford, UK.

Brett J Manley (BJ)

Newborn Research, The Royal Women's Hospital, Melbourne, Australia; Department of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Melbourne, Australia; Neonatal Research, Murdoch Children's Research Institute, Melbourne, Australia.

Classifications MeSH