TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis.
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
28
08
2023
accepted:
16
11
2023
revised:
07
11
2023
medline:
2
12
2023
pubmed:
2
12
2023
entrez:
1
12
2023
Statut:
epublish
Résumé
The long non-coding RNA (lncRNA) TMEM44-AS1 is a novel lncRNA whose pro-carcinogenic role in gastric cancer and glioma has been demonstrated. However, its function in esophageal squamous cell carcinoma (ESCC) is unknown. In this study, we identified that TMEM44-AS1 was highly expressed in ESCC tissues and cells. Functionally, TMEM44-AS1 promoted ESCC cell proliferation, invasion and metastasis in vitro and in vivo. TMEM44-AS1 inhibited ferroptosis in ESCC cells, and ferroptosis levels were significantly increased after knockdown of TMEM44-AS1. Mechanistically, TMEM44-AS1 was positively correlated with GPX4 expression, and TMEM44-AS1 could bind to the RNA-binding protein IGF2BP2 to enhance the stability of GPX4 mRNA, thereby affecting ferroptosis and regulating the malignant progression of ESCC. In summary, this study reveals the TMEM44-AS1-IGF2BP2-GPX4 axis could influence cancer progression in ESCC. TMEM44-AS1 can be used as a potential treatment target against ESCC.
Identifiants
pubmed: 38040698
doi: 10.1038/s41420-023-01727-0
pii: 10.1038/s41420-023-01727-0
pmc: PMC10692126
doi:
Types de publication
Journal Article
Langues
eng
Pagination
431Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82172351
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82173018
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82002751
Organisme : Natural Science Foundation of Henan Province (Henan Province Natural Science Foundation)
ID : 212300410395
Informations de copyright
© 2023. The Author(s).
Références
Life Sci. 2020 Nov 1;260:118305
pubmed: 32827544
Cell Death Dis. 2021 Apr 6;12(4):349
pubmed: 33824282
J Hematol Oncol. 2019 Mar 29;12(1):34
pubmed: 30925886
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Cell Death Differ. 2016 Mar;23(3):369-79
pubmed: 26794443
World J Gastrointest Oncol. 2014 May 15;6(5):112-20
pubmed: 24834141
Mol Ther. 2021 Jul 7;29(7):2185-2208
pubmed: 33794363
Asian J Surg. 2018 May;41(3):210-215
pubmed: 27986415
Cell Death Dis. 2020 Feb 3;11(2):88
pubmed: 32015325
Nat Cell Biol. 2019 May;21(5):542-551
pubmed: 31048766
Semin Cancer Biol. 2014 Dec;29:3-12
pubmed: 25068994
Int J Mol Sci. 2020 Apr 23;21(8):
pubmed: 32340118
Free Radic Biol Med. 2020 May 20;152:175-185
pubmed: 32165281
Cell Death Dis. 2021 Aug 24;12(9):806
pubmed: 34429400
Nat Commun. 2021 Mar 11;12(1):1589
pubmed: 33707434
Int J Biochem Cell Biol. 2021 Jul;136:106015
pubmed: 34022433
J Exp Clin Cancer Res. 2021 Feb 1;40(1):52
pubmed: 33526059
Nat Rev Cancer. 2021 Jan;21(1):22-36
pubmed: 33082563
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Cell Death Differ. 2022 Sep;29(9):1850-1863
pubmed: 35338333
Cancer Cell Int. 2021 Feb 10;21(1):99
pubmed: 33568150
Gastroenterology. 2018 Jan;154(2):360-373
pubmed: 28823862
Nat Rev Mol Cell Biol. 2021 Apr;22(4):266-282
pubmed: 33495651
Immunol Rev. 2017 May;277(1):150-157
pubmed: 28462529
Oncogene. 2023 Jan;42(2):83-98
pubmed: 36369321
Cell Death Dis. 2022 Nov 18;13(11):967
pubmed: 36400758
Nat Rev Clin Oncol. 2021 May;18(5):280-296
pubmed: 33514910
Cell Death Dis. 2021 Nov 2;12(11):1043
pubmed: 34728613
J Exp Clin Cancer Res. 2021 Oct 25;40(1):337
pubmed: 34696771
Lancet. 2013 Feb 2;381(9864):400-12
pubmed: 23374478
Nat Rev Mol Cell Biol. 2016 Dec;17(12):756-770
pubmed: 27780979
Adv Sci (Weinh). 2022 Aug;9(22):e2105077
pubmed: 35717675
J Hematol Oncol. 2022 May 7;15(1):52
pubmed: 35526050
Cell Death Differ. 2018 Nov;25(11):1980-1995
pubmed: 29511340
Nat Rev Mol Cell Biol. 2021 Feb;22(2):96-118
pubmed: 33353982