Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson's disease.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
19
04
2023
accepted:
23
11
2023
medline:
4
12
2023
pubmed:
2
12
2023
entrez:
1
12
2023
Statut:
epublish
Résumé
Few studies have considered the influence of motor sign asymmetry on motivated behaviors in de novo drug-naïve Parkinson's disease (PD). We tested whether motor sign asymmetry could be associated with different motivated behavior patterns in de novo drug-naïve PD. We performed a cross-sectional study in 128 de novo drug-naïve PD patients and used the Ardouin Scale of Behavior in Parkinson's disease (ASBPD) to assess a set of motivated behaviors. We assessed motor asymmetry based on (i) side of motor onset and (ii) MDS-UPDRS motor score, then we compared right hemibody Parkinson's disease to left hemibody Parkinson's disease. According to the MDS-UPDRS motor score, patients with de novo right hemibody PD had significantly lower frequency of approach behaviors (p = 0.031), including nocturnal hyperactivity (p = 0.040), eating behavior (p = 0.040), creativity (p = 0.040), and excess of motivation (p = 0.017) than patients with de novo left hemibody PD. Patients with de novo left hemibody PD did not significantly differ from those with de novo right hemibody PD regarding avoidance behaviors including apathy, anxiety and depression. Our findings suggest that motor sign asymmetry may be associated with an imbalance between motivated behaviors in de novo drug-naïve Parkinson's disease.
Identifiants
pubmed: 38040775
doi: 10.1038/s41598-023-48188-0
pii: 10.1038/s41598-023-48188-0
pmc: PMC10692157
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21234Informations de copyright
© 2023. The Author(s).
Références
Transl Psychiatry. 2022 Jan 24;12(1):29
pubmed: 35075120
Brain. 2018 Jan 1;141(1):288-301
pubmed: 29228211
Brain Sci. 2021 Aug 03;11(8):
pubmed: 34439653
J Parkinsons Dis. 2022;12(4):1329-1337
pubmed: 35253781
Behav Cogn Neurosci Rev. 2005 Mar;4(1):3-20
pubmed: 15886400
Mov Disord. 2017 Dec;32(12):1679-1683
pubmed: 29150871
Brain. 2023 Oct 03;:
pubmed: 37787488
Mov Disord. 2015 Feb;30(2):229-37
pubmed: 25449044
Neuroimage. 2019 Apr 15;190:79-93
pubmed: 30465864
Brain Behav. 2016 Oct 19;7(1):e00590
pubmed: 28127512
Mov Disord. 2011 May;26(6):1022-31
pubmed: 21626547
J Clin Exp Neuropsychol. 2013;35(1):71-82
pubmed: 23320400
Cortex. 2014 Feb;51:82-91
pubmed: 24267688
J Neurosci. 2015 Oct 28;35(43):14491-500
pubmed: 26511241
Handb Clin Neurol. 2021;183:155-167
pubmed: 34389115
Lancet Neurol. 2006 Sep;5(9):796-802
pubmed: 16914408
Mov Disord. 2016 Aug;31(8):1103-13
pubmed: 27041545
Biol Psychol. 2004 Oct;67(1-2):219-33
pubmed: 15130532
Parkinsonism Relat Disord. 2015 Jun;21(6):590-6
pubmed: 25825242
Lancet Neurol. 2015 May;14(5):518-31
pubmed: 25895932
Mov Disord. 2021 Feb;36(2):327-339
pubmed: 33289195
Brain Cogn. 2008 Jun;67(1):1-10
pubmed: 18022303
Neuropsychologia. 1981;19(4):609-13
pubmed: 7279195
Rev Neurol (Paris). 2018 Nov;174(9):653-663
pubmed: 30224159
Lancet Neurol. 2009 Dec;8(12):1128-39
pubmed: 19909911
Neuropsychologia. 2013 Apr;51(5):818-24
pubmed: 23422331
Mov Disord. 2013 Dec;28(14):1920-9
pubmed: 24123087
Parkinsonism Relat Disord. 2013 Feb;19(2):256-9
pubmed: 23178144
J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):72-6
pubmed: 2709038
Parkinsonism Relat Disord. 2015 Sep;21(9):1096-100
pubmed: 26173702
Sci Rep. 2022 Feb 22;12(1):3007
pubmed: 35194127
Mov Disord. 2020 Jun;35(6):1080-1081
pubmed: 32311121
Rev Neurol (Paris). 2009 Nov;165(11):845-56
pubmed: 19683776
Mov Disord. 2015 Apr 15;30(5):705-13
pubmed: 25809278
Parkinsonism Relat Disord. 2012 Nov;18(9):1034-8
pubmed: 22789824
Brain. 2016 Sep;139(Pt 9):2486-502
pubmed: 27538418
NPJ Parkinsons Dis. 2020 Dec 15;6(1):41
pubmed: 33319786
Cell Tissue Res. 2018 Jul;373(1):297-312
pubmed: 29656343
Lancet Neurol. 2017 Mar;16(3):238-250
pubmed: 28229895
Mov Disord. 2021 Dec;36(12):2888-2900
pubmed: 34494685
Prog Neurobiol. 2015 Sep;132:96-168
pubmed: 26209473
Cells. 2023 Jun 10;12(12):
pubmed: 37371068