Optimizing Immature Testicular Tissue and Cell Transplantation Results: Comparing Transplantation Sites and Scaffolds.

Injection Scaffold Spermatogonial Stem Cells Transplantation

Journal

International journal of fertility & sterility
ISSN: 2008-076X
Titre abrégé: Int J Fertil Steril
Pays: Iran
ID NLM: 101487941

Informations de publication

Date de publication:
01 Nov 2023
Historique:
received: 10 08 2022
pmc-release: 01 01 2024
medline: 2 12 2023
pubmed: 2 12 2023
entrez: 2 12 2023
Statut: epublish

Résumé

For patients who had testicular tissue cryopreserved before receiving gonadotoxic therapies, transplantation of testicular tissues and cells has been recommended as a potential therapeutic option. There are no studies that indicate the generation of sperm after human immature testicular tissue (ITT) or spermatogonial stem cells (SSCs) transplantation. The use of releasing scaffolds and localized drug delivery systems as well as the optimizing transplantation site can play an effective role in increasing the efficiency and improving the quality of testicular tissue and cell transplantation in animal models. Current research is focused on optimizing ITT and cell transplantation, the use of releasing scaffolds, and the selection of the right transplantation site that might restore sperm production or male infertility treatment. By searching the PubMed and Google Scholar databases, original and review papers were collected. Search terms were relevant for SSCs and tissue transplantation. In this review, we'll focus on the potential advantages of using scaffolds and choosing the right transplantation site to improve transplantation outcomes.

Identifiants

pubmed: 38041454
doi: 10.22074/ijfs.2023.559999.1350
pmc: PMC10692742
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

12-19

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Auteurs

Alireza Anvari (A)

Department of Anatomical Sciences, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.

Mansoureh Movahedin (M)

Department of Anatomical Sciences, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran. Email: movahed.m@modares.ac.ir.

Maedeh Hamzeh (M)

Department of Anatomical Sciences, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.

Classifications MeSH