Influence of blood hemodynamics on the treatment outcomes of limited fluid resuscitation in emergency patients with traumatic hemorrhagic shock.
Cytokine
Hemodynamics parameters
Limited fluid resuscitation
Mean arterial pressure
Traumatic hemorrhagic shock
Journal
Clinics (Sao Paulo, Brazil)
ISSN: 1980-5322
Titre abrégé: Clinics (Sao Paulo)
Pays: United States
ID NLM: 101244734
Informations de publication
Date de publication:
2023
2023
Historique:
received:
07
08
2023
revised:
02
10
2023
accepted:
25
10
2023
medline:
7
12
2023
pubmed:
3
12
2023
entrez:
2
12
2023
Statut:
epublish
Résumé
Traumatic hemorrhagic shock is a major death-related factor contributing to mortality in emergencies and can be effectively handled by the Limited Fluid Resuscitation (LFR) method. In the current investigation, the authors analyzed the influence of different administrating blood pressure on the treatment outcomes of LFR. 276 participants were enrolled in the current study retrospectively from January 2016 to December 2021 and were divided into three groups based on the administrating blood pressure of LFR. The difference among the three groups regarding serum levels of cytokines as well as blood hemodynamics parameters was analyzed. The results showed after the T2 stage treatment, cytokine levels in the three groups were all significantly influenced by different LFR strategies with medium MAP showing the strongest effects on the expression of all cytokine genes. Moreover, the MAP value was in positive correlation with IL-6, IL-10, and TNF-α levels, but showed no clear relation with IL-4 level in all three groups. Regarding the effects on hemodynamics parameters, the levels of CVP, CO, and CI were slightly increased by the different LFR administrating strategies, and the effect of medium and high MAP was statistically stronger than that of low MAP. The present results showed that LFR would influence serum inflammatory levels by improving blood hemodynamics parameters. Medium MAP showed the strongest improving effects with the least side effects, which can be employed as the optimal administrating strategy for LFR in the future.
Identifiants
pubmed: 38041986
pii: S1807-5932(23)00144-8
doi: 10.1016/j.clinsp.2023.100308
pmc: PMC10711384
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100308Informations de copyright
Copyright © 2023 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare no conflicts of interest.
Références
Front Immunol. 2022 Aug 25;13:918380
pubmed: 36091025
Eur J Trauma Emerg Surg. 2018 Apr;44(2):191-202
pubmed: 29079917
Comput Math Methods Med. 2022 Jul 6;2022:4982047
pubmed: 35844441
J Clin Med. 2023 May 31;12(11):
pubmed: 37297968
Front Immunol. 2018 Feb 05;8:1977
pubmed: 29459855
J Intensive Care. 2017 Jan 20;5(1):11
pubmed: 34798698
Semin Vasc Surg. 2023 Jun;36(2):283-299
pubmed: 37330241
Crit Care Clin. 2017 Jan;33(1):15-36
pubmed: 27894494
Microcirculation. 2020 Nov;27(8):e12650
pubmed: 32688443
Ann Emerg Med. 1993 Feb;22(2):155-63
pubmed: 8427424
Crit Care. 2013 Mar 05;17(2):208
pubmed: 23672729
Crit Care. 2016 Apr 12;20:100
pubmed: 27072503
Shock. 2016 Apr;45(4):338-48
pubmed: 26513707
Crit Care. 2015 Apr 20;19:170
pubmed: 25927673
Anesthesiology. 2012 Jan;116(1):103-12
pubmed: 22094312
Pak J Med Sci. 2018 Sep-Oct;34(5):1120-1124
pubmed: 30344561
JAMA. 2015 Feb 3;313(5):471-82
pubmed: 25647203
Intensive Care Med. 2014 Dec;40(12):1795-815
pubmed: 25392034
J Trauma Acute Care Surg. 2013 Jul;75(1 Suppl 1):S24-30
pubmed: 23778507