Crosstalk between GABA

GABA(A) receptor astrocyte crosstalk general anesthetic neuron

Journal

Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339

Informations de publication

Date de publication:
01 Dec 2023
Historique:
received: 18 08 2023
revised: 17 11 2023
accepted: 29 11 2023
pubmed: 3 12 2023
medline: 3 12 2023
entrez: 2 12 2023
Statut: aheadofprint

Résumé

General anesthetic drugs cause cognitive deficits that persist after the drugs have been eliminated. Astrocytes may contribute to such cognition-impairing effects through the release of one or more paracrine factors that increase a tonic inhibitory conductance generated by extrasynaptic γ-aminobutyric acid type A (GABA

Identifiants

DOI: 10.1016/j.trsl.2023.11.007 PMID: 38042478
pubmed: 38042478
pii: S1931-5244(23)00201-3
doi: 10.1016/j.trsl.2023.11.007
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors have read the journal's policy on disclosure of potential conflicts of interest. Dr. Beverley A. Orser serves as Chair of the Board of Trustees of the International Anesthesia Research Society (San Francisco, CA, USA) and is co-director of the Perioperative Brain Health Centre (Toronto, ON, Canada; http://www.perioperativebrainhealth.com). She is a named inventor on a Canadian patent (2,852,978) and two U.S. patents (9,517,265 and 10,981,954). The patents, which are held by the University of Toronto, are for new methods to prevent and treat delirium and persistent neurocognitive deficits after anesthesia and surgery, as well as to treat mood disorders. Dr. Beverley A. Orser also collaborates on clinical studies that are supported by in-kind software. All of the other authors declare no conflicts of interest.

Auteurs

Dian-Shi Wang (DS)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Li Ju (L)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Arsène G Pinguelo (AG)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Kirusanthy Kaneshwaran (K)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Sean C Haffey (SC)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Irene Lecker (I)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Himaben Gohil (H)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Michael B Wheeler (MB)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.

Lilia Kaustov (L)

Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Anthony Ariza (A)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

MeiFeng Yu (M)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Allen Volchuk (A)

Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.

Benjamin E Steinberg (BE)

Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Anesthesiology & Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Room 3318, Medical Sciences Building, 1 King's College Circle, Ontario M5S 1A8, Canada.

Neil M Goldenberg (NM)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Anesthesiology & Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Room 3318, Medical Sciences Building, 1 King's College Circle, Ontario M5S 1A8, Canada; Program in Neurosciences & Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

Beverley A Orser (BA)

Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Anesthesiology & Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Room 3318, Medical Sciences Building, 1 King's College Circle, Ontario M5S 1A8, Canada. Electronic address: beverley.orser@utoronto.ca.

Classifications MeSH