Health-related quality of life is linked to the gut microbiome in kidney transplant recipients.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 Dec 2023
02 Dec 2023
Historique:
received:
12
02
2023
accepted:
08
11
2023
medline:
4
12
2023
pubmed:
3
12
2023
entrez:
2
12
2023
Statut:
epublish
Résumé
Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = -0.20, P = 2.3 × 10
Identifiants
pubmed: 38042820
doi: 10.1038/s41467-023-43431-8
pii: 10.1038/s41467-023-43431-8
pmc: PMC10693618
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7968Investigateurs
C Annema
(C)
F A J A Bodewes
(FAJA)
M T de Boer
(MT)
K Damman
(K)
A Diepstra
(A)
G Dijkstra
(G)
C S E Doorenbos
(CSE)
M F Eisenga
(MF)
M E Erasmus
(ME)
C T Gan
(CT)
A W Gomes Neto
(AWG)
E Hak
(E)
B G Hepkema
(BG)
F Klont
(F)
H G D Leuvenink
(HGD)
W S Lexmond
(WS)
G J Nieuwenhuis-Moeke
(GJ)
H G M Niesters
(HGM)
L J van Pelt
(LJ)
A V Ranchor
(AV)
J S F Sanders
(JSF)
M J Siebelink
(MJ)
R J H J A Slart
(RJHJA)
D J Touw
(DJ)
M C van den Heuvel
(MC)
C van Leer-Buter
(C)
M van Londen
(M)
E A M Verschuuren
(EAM)
M J Vos
(MJ)
Informations de copyright
© 2023. The Author(s).
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