Orexin deficiency modulates the dipsogenic effects of angiotensin II in a sex-dependent manner.
Angiotensin II
Drinking
Hypocretin
Orexin
Polydipsia
Sex differences
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
12
08
2023
revised:
10
11
2023
accepted:
28
11
2023
pubmed:
4
12
2023
medline:
4
12
2023
entrez:
3
12
2023
Statut:
aheadofprint
Résumé
The orexin (hypocretin) neuropeptide system is an important regulator of ingestive behaviors, i.e., it promotes food and water intake. Here, we investigated the role of orexin in drinking induced by the potent dipsogen angiotensin II (ANG II). Specifically, male and female orexin-deficient mice received intracerebroventricular (ICV) injections of ANG II, followed by measuring their water intake within 15 min. We found that lower doses of ANG II (100 ng) significantly stimulated drinking in males but not in females, indicating a general sex-dependent effect that was not affected by orexin deficiency. However, higher doses of ANG II (500 ng) were sufficient to induce drinking in female wild-type mice, while female orexin-deficient mice still did not respond to the dipsogenic properties of ANG II. In conclusion, these results suggest sex-dependent effects in ANG II-induced drinking and further support the sexual dimorphism of orexin system functions.
Identifiants
pubmed: 38043589
pii: S0196-9781(23)00192-4
doi: 10.1016/j.peptides.2023.171127
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
171127Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.