Interference by piperacillin/tazobactam in the measurement of creatinine with the Jaffe method and of total protein with the biuret method.
Journal
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
ISSN: 1441-2772
Titre abrégé: Crit Care Resusc
Pays: Netherlands
ID NLM: 100888170
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
medline:
4
12
2023
pubmed:
4
12
2023
entrez:
4
12
2023
Statut:
epublish
Résumé
Serum creatinine and total protein are routinely measured biochemical parameters used in clinical medicine. An abnormal result caused by interference with the assay does not accurately reflect a patient's clinical state and therefore risks misleading clinicians. We report the case of a patient who had unexplainable high creatinine and total protein results. The blood collection was contaminated with intravenous fluid and the patient was receiving piperacillin/tazobactam. Additional laboratory studies demonstrated piperacillin/tazobactam was the cause of the false positive results and the elevation in both serum creatinine and protein level was dependent on the concentration of antibiotic present.
Identifiants
pubmed: 38045524
doi: 10.51893/2021.2.cr1
pii: S1441-2772(23)00419-2
pmc: PMC10692513
doi:
Types de publication
Case Reports
Langues
eng
Pagination
141-143Informations de copyright
© 2021 College of Intensive Care Medicine of Australia and New Zealand.
Déclaration de conflit d'intérêts
No relevant disclosures.
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