Gut microbiota signatures and modulation in irritable bowel syndrome.
Gut microbiota
diarrhea
irritable bowel syndrome
metabolome
Journal
Microbiome research reports
ISSN: 2771-5965
Titre abrégé: Microbiome Res Rep
Pays: United States
ID NLM: 9918681186206676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
14
12
2021
revised:
27
01
2022
accepted:
15
02
2022
medline:
5
3
2022
pubmed:
5
3
2022
entrez:
4
12
2023
Statut:
epublish
Résumé
Irritable bowel syndrome (IBS) affects approximately one tenth of the general population and is characterized by abdominal pain associated with abnormalities in bowel habits. Visceral hypersensitivity, abnormal intestinal motor function, mucosal immune activation, and increased intestinal permeability concur to its pathophysiology. Psychological factors can influence symptom perception at the central nervous system level. In addition, recent evidence suggests that dysbiosis may be a key pathophysiological factor in patients with IBS. Increasing understanding of the pathophysiological mechanisms translates into new and more effective therapeutic approaches. Indeed, in line with this evidence, IBS therapies nowadays include agents able to modulate gut microbiota function and composition, such as diet, prebiotics, probiotics, and antibiotics. In addition, in the last decade, an increasing interest in fecal microbiota transplantation has been paid. An in-depth understanding of the intestinal microenvironment through accurate faucal microbiota and metabolite analysis may provide valuable insights into the pathophysiology of IBS, finally shaping new tailored IBS therapies.
Identifiants
pubmed: 38045643
doi: 10.20517/mrr.2021.12
pmc: PMC10688783
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
11Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
All authors declared that there are no conflicts of interest.
Références
Sci Rep. 2015 Aug 04;5:12693
pubmed: 26239401
J Pak Med Assoc. 2007 Jun;57(6):285-7
pubmed: 17629228
J Gastroenterol Hepatol. 2021 Feb;36(2):446-454
pubmed: 32666516
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
Gut. 2017 Jun;66(6):1075-1082
pubmed: 26818616
Curr Opin Pharmacol. 2018 Dec;43:87-92
pubmed: 30219638
Gut. 2012 Sep;61(9):1284-90
pubmed: 22234979
Medicine (Baltimore). 2019 Feb;98(7):e14513
pubmed: 30762787
Science. 2012 Jun 8;336(6086):1268-73
pubmed: 22674334
Curr Opin Biotechnol. 2013 Apr;24(2):160-8
pubmed: 22940212
Neurogastroenterol Motil. 2018 Dec;30(12):e13513
pubmed: 30460770
Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2986-3000
pubmed: 31002149
Lancet Gastroenterol Hepatol. 2020 Jul;5(7):658-666
pubmed: 32277872
Clin Transl Gastroenterol. 2019 Feb;10(2):e00012
pubmed: 30829919
Dig Liver Dis. 2018 Aug;50(8):741-749
pubmed: 29807873
Gastroenterology. 2020 Mar;158(4):1016-1028.e8
pubmed: 31843589
JAMA. 2021 Mar 02;325(9):865-877
pubmed: 33651094
Adv Immunol. 2014;121:91-119
pubmed: 24388214
Nat Rev Immunol. 2010 Oct;10(10):735-44
pubmed: 20865020
Gut. 2017 Apr;66(4):569-580
pubmed: 28087657
Gastroenterology. 2021 Jan;160(1):99-114.e3
pubmed: 32294476
Gastroenterology. 2019 Jul;157(1):97-108
pubmed: 30940523
Gut. 2020 May;69(5):795-796
pubmed: 32102925
Inflamm Bowel Dis. 2012 Apr;18(4):649-56
pubmed: 21826768
Gastroenterology. 2020 Aug;159(2):708-738.e4
pubmed: 32531292
Aliment Pharmacol Ther. 2014 Nov;40(9):1094-102
pubmed: 25175998
Neurogastroenterol Motil. 2020 Sep;32(9):e13874
pubmed: 32431019
Gut. 2018 May;67(5):872-881
pubmed: 28416515
Am J Gastroenterol. 2018 Jan;113(1):86-96
pubmed: 29134969
Neurogastroenterol Motil. 2012 Jun;24(6):521-30, e248
pubmed: 22339879
Aliment Pharmacol Ther. 2019 Aug;50(3):240-248
pubmed: 31136009
Aliment Pharmacol Ther. 2015 Mar;41(5):449-58
pubmed: 25586008
Gut. 2022 Sep;71(9):1821-1830
pubmed: 34810234
Am J Gastroenterol. 2012 Feb;107(2):286-95
pubmed: 22068664
Scand J Gastroenterol. 2003 Oct;38(10):1031-8
pubmed: 14621276
Immunity. 2015 Nov 17;43(5):845-58
pubmed: 26588778
Clin Gastroenterol Hepatol. 2012 Jul;10(7):712-721.e4
pubmed: 22426087
United European Gastroenterol J. 2018 May;6(4):604-613
pubmed: 29881616
Aliment Pharmacol Ther. 2018 Nov;48(10):1044-1060
pubmed: 30294792
Gastroenterology. 2016 Dec;151(6):1113-1121
pubmed: 27528177
Gastroenterol Clin North Am. 2021 Sep;50(3):523-545
pubmed: 34304786
Gut. 2020 May;69(5):859-867
pubmed: 31852769
Lancet. 2020 Nov 21;396(10263):1675-1688
pubmed: 33049223
Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G52-G62
pubmed: 27881403
Gastroenterology. 2014 Jul;147(1):69-77
pubmed: 24657623
Am J Gastroenterol. 2018 Sep;113(9):1290-1300
pubmed: 30046155
Science. 2005 Mar 25;307(5717):1915-20
pubmed: 15790844
Nature. 2016 Jul 06;535(7610):85-93
pubmed: 27383983
World J Gastroenterol. 2017 Jul 7;23(25):4491-4499
pubmed: 28740337
Gastroenterology. 2019 Jan;156(1):46-58.e7
pubmed: 30009817
Adv Exp Med Biol. 2008;635:15-28
pubmed: 18841700
Eur J Nutr. 2021 Sep;60(6):3505-3522
pubmed: 33585949
Cells. 2021 Jun 10;10(6):
pubmed: 34200772
FEMS Microbiol Rev. 2014 Sep;38(5):996-1047
pubmed: 24861948
United European Gastroenterol J. 2018 Oct;6(8):1245-1253
pubmed: 30288287
Environ Microbiol. 2018 Sep;20(9):3201-3213
pubmed: 29749705
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502
pubmed: 28611480
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
Science. 2009 Dec 18;326(5960):1694-7
pubmed: 19892944
Am J Gastroenterol. 2015 Feb;110(2):278-87
pubmed: 25623659
Cell. 2020 Sep 17;182(6):1460-1473.e17
pubmed: 32916129
Aliment Pharmacol Ther. 2019 Jul;50(2):132-143
pubmed: 31157418
Cell Host Microbe. 2019 Oct 9;26(4):527-541.e5
pubmed: 31600503
Am J Gastroenterol. 2021 Jan 1;116(1):17-44
pubmed: 33315591
Health Qual Life Outcomes. 2017 Feb 14;15(1):35
pubmed: 28196491
Gastroenterology. 2017 Jan;152(1):111-123.e8
pubmed: 27725146
EFSA J. 2021 Jun 11;19(6):e06641
pubmed: 34136006
Gut. 2021 Jul;70(7):1214-1240
pubmed: 33903147
N Engl J Med. 2011 Jan 6;364(1):22-32
pubmed: 21208106
Gastroenterology. 2016 Feb 18;:
pubmed: 27144620
Gastroenterology. 2016 Feb 19;:
pubmed: 27144617
Microb Ecol Health Dis. 2015 Feb 02;26:26191
pubmed: 25651997
J Clin Gastroenterol. 2020 Feb;54(2):175-183
pubmed: 30148765
Front Nutr. 2021 Sep 13;8:718356
pubmed: 34589512
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14
pubmed: 24912386
Am J Gastroenterol. 2002 Jan;97(1):104-8
pubmed: 11808932
Pain. 2008 Jul;137(1):147-155
pubmed: 17928145
Gastroenterology. 2016 Feb 18;:
pubmed: 27144627
Gut. 2018 Jun;67(6):1078-1086
pubmed: 28601847
Gastroenterology. 2020 Aug;159(2):697-705
pubmed: 32531291