Malignancy in Thyroid Nodules with Bethesda III Category on Repeat Fine Needle Aspiration Biopsy.
AUS/FLUS
Bethesda III
malignancy
Journal
Journal of the ASEAN Federation of Endocrine Societies
ISSN: 2308-118X
Titre abrégé: J ASEAN Fed Endocr Soc
Pays: Philippines
ID NLM: 8608483
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
02
2023
accepted:
11
04
2023
medline:
5
12
2023
pubmed:
4
12
2023
entrez:
4
12
2023
Statut:
ppublish
Résumé
This study aimed to evaluate the risk of malignancy for nodules repeatedly classified as Bethesda category III on fine needle aspiration biopsy (FNAB). A chart review on a series of 59 patients seen with thyroid nodules who underwent both initial and repeat FNAB at the Diabetes, Thyroid and Endocrine Center of St. Luke's Medical Center, Quezon City was conducted. The Thyroid Registry was utilized to collect each patient's demographic and clinical characteristics, ultrasonographic features of thyroid nodules along with the cytopathologic and histopathologic results. The subclassification of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) were retrieved from the cytopathology reports using the institution's electronic Healthcare-Results Management System. A total of 59 adult patients with thyroid nodules were included. Nodules which were initially AUS/FLUS turned out to be malignant on repeat FNAB in 38 patients with a prevalence of 64.41% (95% CI: 50.87-76.45%). There was no significant difference with regards to clinical, ultrasonographic and cytopathologic features of malignancy between benign and malignant nodules. Findings of this study support surgical intervention as a reasonable option after a repeat Bethesda III classification on FNAB. However, the small sample size warrants confirmation in future studies with a representative sample of patients.
Identifiants
pubmed: 38045668
doi: 10.15605/jafes.038.02.19
pii: JAFES-38-2-86
pmc: PMC10692425
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-93Informations de copyright
© 2023 Journal of the ASEAN Federation of Endocrine Societies.
Déclaration de conflit d'intérêts
The authors declared no conflict of interest.
Références
Cytojournal. 2014 Aug 28;11:23
pubmed: 25210530
Gland Surg. 2020 Oct;9(5):1788-1796
pubmed: 33224855
Am J Clin Pathol. 2011 May;135(5):770-5
pubmed: 21502433
Int J Endocrinol. 2018 Jul 30;2018:4521984
pubmed: 30154840
Head Neck. 2017 Aug;39(8):1699-1710
pubmed: 28493558
Thyroid. 2009 Nov;19(11):1167-214
pubmed: 19860577
Cancer Cytopathol. 2017 Apr;125(4):245-256
pubmed: 28192631
Thyroid. 2017 Nov;27(11):1341-1346
pubmed: 29091573
Eur J Endocrinol. 2022 Jul 29;187(3):R41-R52
pubmed: 35900312
Endocr Pract. 2010 May-Jun;16(3):468-75
pubmed: 20551008
PLoS One. 2018 Aug 17;13(8):e0202687
pubmed: 30118506
Thyroid. 2012 May;22(5):468-75
pubmed: 22304417
Thyroid. 2014 May;24(5):832-9
pubmed: 24341462
Thyroid. 2019 Sep;29(9):1237-1243
pubmed: 31407625
Endocr J. 2012;59(3):205-12
pubmed: 22156326
Radiol Oncol. 2018 Sep 27;52(4):370-376
pubmed: 30265655
Surgery. 2012 Dec;152(6):1037-44
pubmed: 23040711
Thyroid. 2009 Nov;19(11):1159-65
pubmed: 19888858
J Clin Endocrinol Metab. 2016 Jul;101(7):2853-62
pubmed: 27014951
Surgery. 2013 Oct;154(4):730-6; discussion 736-8
pubmed: 24074409
PLoS One. 2015 Jun 26;10(6):e0130138
pubmed: 26115096
Acta Cytol. 2021;65(3):205-212
pubmed: 33524971
Clin Endocrinol (Oxf). 2014 May;80(5):735-42
pubmed: 24117478
Eur Thyroid J. 2020 Feb;9(2):92-98
pubmed: 32257958
Endocr Pathol. 2013 Jun;24(2):62-8
pubmed: 23595630
Thyroid. 2014 Jul;24(7):1115-20
pubmed: 24684285
Am J Clin Pathol. 2011 Jun;135(6):852-9
pubmed: 21571958
Ann Surg Oncol. 2013 Sep;20(9):3083-8
pubmed: 23700214
Eur J Endocrinol. 2021 Aug 27;185(4):497-506
pubmed: 34313606
World J Surg. 2014 Mar;38(3):628-33
pubmed: 24233659