Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.

biomarkers cardiovascular diseases fatty acids, unsaturated medical history taking precision medicine

Journal

Circulation
ISSN: 1524-4539
Titre abrégé: Circulation
Pays: United States
ID NLM: 0147763

Informations de publication

Date de publication:
04 Dec 2023
Historique:
medline: 4 12 2023
pubmed: 4 12 2023
entrez: 4 12 2023
Statut: aheadofprint

Résumé

It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction. After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.

Sections du résumé

BACKGROUND UNASSIGNED
It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.
METHODS UNASSIGNED
Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction.
RESULTS UNASSIGNED
After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16];
CONCLUSIONS UNASSIGNED
A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.

Identifiants

DOI: 10.1161/CIRCULATIONAHA.123.065530 PMID: 38047387
pubmed: 38047387
doi: 10.1161/CIRCULATIONAHA.123.065530
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

F Laguzzi (F)

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (F.L., A.A., U.D.F., K.L.).
ORCID: 0000-0003-3551-1348

A Åkesson (A)

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (F.L., A.A., U.D.F., K.L.).
ORCID: 0000-0001-9594-4140

M Marklund (M)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.M., W.S.P).
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.M.).
Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden (M.M., U.R).
ORCID: 0000-0002-3320-796X

F Qian (F)

Section of Cardiovascular Medicine, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, MA (F.Q.).
Department of Nutrition, Boston, MA. (F.Q.).
ORCID: 0000-0002-5579-3410

B Gigante (B)

Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. (B.G.).
ORCID: 0000-0003-4508-7990

T M Bartz (TM)

Cardiovascular Health Research Unit, Department of Biostatistics, University of Washington, Seattle. (T.M.B.).
Department of Medicine, University of Washington, Seattle. (T.M.B., R.N.L., B.M.P.).
ORCID: 0000-0003-3403-8763

J K Bassett (JK)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia (J.K.B., A.M.H., G.G.G.).

A Birukov (A)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal (A.K.B., S.J., M.B.S.).
German Center for Diabetes Research, Neuherberg (A.K.B., S.J., M.B.S.).
ORCID: 0000-0001-9594-4140

H Campos (H)

Harvard T.H. Chan School of Public Healt, Boston, MA. (H.C.).

Y Hirakawa (Y)

Departments of Epidemiology and Public Health and Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.H., T.N.).

F Imamura (F)

Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, UK (F.I., N.G.F., N.J.W.).
ORCID: 0000-0002-6841-8396

S Jäger (S)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal (A.K.B., S.J., M.B.S.).
German Center for Diabetes Research, Neuherberg (A.K.B., S.J., M.B.S.).

M Lankinen (M)

Institutes of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. (M. Lankinen, J.K.V., M.U.).
ORCID: 0000-0002-9158-283X

R A Murphy (RA)

Cancer Control Research, BC Cancer Agency, Vancouver, Canada (R.A.M.).
School of Population and Public Health, University of British Columbia, Vancouver, Canada (R.A.M.).
ORCID: 0000-0003-4383-5641

M Senn (M)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX (M.S., A.C.W.).
ORCID: 0000-0002-0298-8142

T Tanaka (T)

Longitudinal Study Section, National Institute on Aging, Baltimore, MD (T.T., L.F.).

N Tintle (N)

Departments of Epidemiology and Public Health and Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (Y.H., T.N.).
ORCID: 0000-0003-1447-9107

J K Virtanen (JK)

Institutes of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. (M. Lankinen, J.K.V., M.U.).
ORCID: 0000-0002-0648-999X

K Yamagishi (K)

Department of Public Health Medicine, Institute of Medicine, University of Tsukuba, Japan. (K.Y., H.K.).
Health Services Research and Development Center, University of Tsukuba, Japan. (K.Y., H.K.).

M Allison (M)

Department of Family Medicine, University of California, San Diego, La Jolla (M.A.).
ORCID: 0000-0003-0777-8272

I A Brouwer (IA)

Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (I.A.B.).
Amsterdam Public Health Research Institute, The Netherlands (I.A.B.).
ORCID: 0000-0002-8762-382X

U De Faire (U)

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (F.L., A.A., U.D.F., K.L.).
ORCID: 0000-0002-6000-3698

G Eiriksdottir (G)

Icelandic Heart Association, Kopavogur (G.E., V.G.).
ORCID: 0000-0002-8197-0652

L Ferrucci (L)

Longitudinal Study Section, National Institute on Aging, Baltimore, MD (T.T., L.F.).
ORCID: 0000-0002-6273-1613

N G Forouhi (NG)

Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, UK (F.I., N.G.F., N.J.W.).

J M Geleijnse (JM)

Division of Human Nutrition and Health, Wageningen University and Research, The Netherlands (J.M.G., A.C.v.W.).
ORCID: 0000-0001-7638-0589

A M Hodge (AM)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia (J.K.B., A.M.H., G.G.G.).
Centre for Epidemiology and Biostatistics, University of Melbourne, Victoria, Australia (A.M.H., G.G.G.).
ORCID: 0000-0001-5464-2197

H Kimura (H)

Department of Public Health Medicine, Institute of Medicine, University of Tsukuba, Japan. (K.Y., H.K.).
Health Services Research and Development Center, University of Tsukuba, Japan. (K.Y., H.K.).
ORCID: 0000-0001-9630-0099

M Laakso (M)

Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio. (M. Laakso).
Kuopio University Hospital, University of Eastern Finland, Kuopio. (M. Laakso).
ORCID: 0000-0002-3394-7749

U Risérus (U)

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Sweden (M.M., U.R).
ORCID: 0000-0002-8620-4586

A C van Westing (AC)

Division of Human Nutrition and Health, Wageningen University and Research, The Netherlands (J.M.G., A.C.v.W.).

S Bandinelli (S)

Geriatric Unit, Azienda USL Toscana Centro, Florence, Italy (S.B.).

A Baylin (A)

University of Michigan School of Public Health, Ann Arbor (A. Baylin).
ORCID: 0000-0001-9594-4140

G G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia (J.K.B., A.M.H., G.G.G.).
Centre for Epidemiology and Biostatistics, University of Melbourne, Victoria, Australia (A.M.H., G.G.G.).
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Victoria, Australia (G.G.G.).
ORCID: 0000-0003-4946-9099

V Gudnason (V)

Icelandic Heart Association, Kopavogur (G.E., V.G.).
Faculty of Medicine, University of Iceland, Reykjavik (V.G.).
ORCID: 0000-0001-5696-0084

H Iso (H)

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan (H.I.).
Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan (H.I.).
ORCID: 0000-0002-9241-7289

R N Lemaitre (RN)

Department of Medicine, University of Washington, Seattle. (T.M.B., R.N.L., B.M.P.).
ORCID: 0000-0002-7038-1844

T Ninomiya (T)

Fatty Acid Research Institute, Sioux Falls, SD (N.T., W.S.H.).
Department of Population Health Nursing Science, University of Illinois - Chicago (N.T.).

W S Post (WS)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.M., W.S.P).
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P.).
ORCID: 0000-0002-8655-5204

B M Psaty (BM)

Department of Medicine, University of Washington, Seattle. (T.M.B., R.N.L., B.M.P.).
Department of Epidemiology, University of Washington, Seattle. (B.M.P.).
Department of Health Systems and Population Health, University of Washington, Seattle. (B.M.P.).
ORCID: 0000-0002-7278-2190

J T Salonen (JT)

Metabolic Analytical Services Oy, Helsinki, Finland (J.T.S.).
University of Helsinki, the Faculty of Medicine, Department of Public Health, Finland (J.T.S.).

M B Schulze (MB)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal (A.K.B., S.J., M.B.S.).
German Center for Diabetes Research, Neuherberg (A.K.B., S.J., M.B.S.).
Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany (M.B.S.).
ORCID: 0000-0002-0830-5277

M Y Tsai (MY)

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (M.Y.T.).
ORCID: 0000-0001-7553-3408

M Uusitupa (M)

Institutes of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. (M. Lankinen, J.K.V., M.U.).
ORCID: 0000-0001-6052-2001

N J Wareham (NJ)

Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, UK (F.I., N.G.F., N.J.W.).
ORCID: 0000-0003-1422-2993

S W Oh (SW)

Department of Family Medicine, Seoul National University College of Medicine, and Healthcare System Gangnam Center, Seoul National University Hospital, Republic of Korea (S.W.O.).
ORCID: 0000-0003-3800-0754

A C Wood (AC)

United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX (M.S., A.C.W.).
ORCID: 0000-0001-7616-2119

W S Harris (WS)

Fatty Acid Research Institute, Sioux Falls, SD (N.T., W.S.H.).
Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls (W.S.H.).

D Siscovick (D)

The New York Academy of Medicine, New York (D.S.).
ORCID: 0000-0003-0461-175X

D Mozaffarian (D)

Food Is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.).
ORCID: 0000-0001-7958-9492

K Leander (K)

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (F.L., A.A., U.D.F., K.L.).
ORCID: 0000-0002-1404-9222

Classifications MeSH