Intraoperative Radioguided Localization of an Occult Neuroendocrine Tumor of the Ileum.

Journal

Clinical nuclear medicine

ISSN: 1536-0229

Titre abrégé: Clin Nucl Med

Pays: United States

ID NLM: 7611109

Informations de publication

Date de publication:
01 Jan 2024

Historique:

pubmed: 4 12 2023

medline: 4 12 2023

entrez: 4 12 2023

Statut: ppublish

Résumé

We report the intraoperative radioguided localization of an occult well-differentiated neuroendocrine tumor of the ileum in a patient with a known neuroendocrine lymphonodal metastasis in the mesentery. Preoperative imaging included CT, PET/CT with 68 Ga-DOTATOC, and SPECT/CT with 99m Tc-HYNICTOC. These scans revealed morphological and functional properties of the primary tumor localized in the ileum. The day after IV 99m Tc-HYNICTOC injection, the patient underwent surgery, and the target lesion was intraoperatively detected by a collimated handheld γ-probe. Postoperative pathology examination confirmed the target lesion to be a neuroendocrine tumor of the ileum.

Identifiants

DOI: 10.1097/RLU.0000000000004971 PMID: 38048563

pubmed: 38048563

doi: 10.1097/RLU.0000000000004971

pii: 00003072-990000000-00837

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

69-70

Informations de copyright

Déclaration de conflit d'intérêts

Conflicts of interest and sources of funding: none declared.

Références

Cockburn KC, Toumi Z, Mackie A, et al. Radioguided surgery for gastroenteropancreatic neuroendocrine tumours: a systematic literature review. J Gastrointest Surg . 2021;25:3244–3257.

Pavel M, Öberg K, Falconi M, et al. Gastroenteropancreatic neuroendocrine neoplasms: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol . 2020;31:844–860.

Pauwels E, Cleeren F, Bormans G, et al. Somatostatin receptor PET ligands—the next generation for clinical practice. Am J Nucl Med Mol Imaging . 2018;8:311–331.

Bozkurt MF, Virgolini I, Balogova S, et al. Guideline for PET/CT imaging of neuroendocrine neoplasms with 68 Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18 F-DOPA. Eur J Nucl Med Mol Imaging . 2017;44:1588–1601.

Cuccurullo V, Di Stasio GD, Mansi L. Radioguided surgery with radiolabeled somatostatin analogs: not only in GEP-NETs. Nucl Med Rev Cent East Eur . 2017;20:49–56.

Massironi S, Sciola V, Peracchi M, et al. Neuroendocrine tumors of the gastro-entero-pancreatic system. World J Gastroenterol . 2008;14:5377–5384.

Hubalewska-Dydejczyk A, Kulig J, Szybinski P, et al. Radio-guided surgery with the use of [ 99m Tc-EDDA/HYNIC]octreotate in intra-operative detection of neuroendocrine tumours of the gastrointestinal tract. Eur J Nucl Med Mol Imaging . 2007;34:1545–1555.

Decristoforo C, Mather SJ, Cholewinski W, et al. 99m Tc-EDDA/HYNIC-TOC: a new 99m Tc-labelled radiopharmaceutical for imaging somatostatin receptor-positive tumours; first clinical results and intra-patient comparison with 111In-labelled octreotide derivatives. Eur J Nucl Med . 2000;27:1318–1325.