Randomized trial of dyadic-report vs. proxy-report/self-report symptom assessment for pediatric patients receiving cancer treatments.
Journal
Journal of the National Cancer Institute
ISSN: 1460-2105
Titre abrégé: J Natl Cancer Inst
Pays: United States
ID NLM: 7503089
Informations de publication
Date de publication:
04 Dec 2023
04 Dec 2023
Historique:
received:
26
09
2023
revised:
17
11
2023
accepted:
27
11
2023
medline:
4
12
2023
pubmed:
4
12
2023
entrez:
4
12
2023
Statut:
aheadofprint
Résumé
We validated different approaches to symptom assessment for pediatric cancer patients based on Symptom Screening in Pediatrics Tool (SSPedi) for self-report (SSPedi and mini-SSPedi), proxy-report (proxy-SSPedi) and a structured dyadic-report (co-SSPedi). Objective was to compare co-SSPedi scores vs proxy-report (proxy-SSPedi) and self-report (SSPedi/mini-SSPedi) scores for pediatric patients receiving cancer treatments. This was a single center, randomized cross-over study enrolling English-speaking dyads of pediatric patients with cancer or hematopoietic cell transplant recipients 4-18 years old and their guardians. Dyads were randomized to first complete dyadic-report (co-SSPedi) or self-report (patients: SSPedi or mini-SSPedi) and proxy-report (guardians: proxy-SSPedi). Dyads then crossed over to the alternate approach. Primary analysis compared total SSPedi scores between randomized groups. We enrolled 420 dyads that were randomized to co-SSPedi first (n = 213) or proxy-SSPedi and self-report SSPedi first (n = 207). Mean total SSPedi scores (± standard deviation) were: co-SSPedi (9.6 ± 7.1), proxy-SSPedi (9.7 ± 7.5; P = .950 for comparison vs co-SSPedi) and self-report SSPedi (9.7 ± 8.2; P = .981 for comparison vs co-SSPedi). Co-SSPedi scores were significantly different than proxy-SSPedi for feeling disappointed or sad, feeling cranky or angry, feeling tired, mouth sores and changes in taste. Co-SSPedi scores were significantly different than self-report SSPedi scores for problems with thinking or remembering things, feeling tired, mouth sores, tingly or numb hand or feet and diarrhea. Total co-SSPedi scores were not significantly different compared with proxy-report or self-report scores although there were differences in specific symptom scores. If different reporter types are used during clinical implementation, specifying reporter type will be important.The study was registered at clinicaltrials.gov (NCT #05012917).
Sections du résumé
BACKGROUND
BACKGROUND
We validated different approaches to symptom assessment for pediatric cancer patients based on Symptom Screening in Pediatrics Tool (SSPedi) for self-report (SSPedi and mini-SSPedi), proxy-report (proxy-SSPedi) and a structured dyadic-report (co-SSPedi). Objective was to compare co-SSPedi scores vs proxy-report (proxy-SSPedi) and self-report (SSPedi/mini-SSPedi) scores for pediatric patients receiving cancer treatments.
METHODS
METHODS
This was a single center, randomized cross-over study enrolling English-speaking dyads of pediatric patients with cancer or hematopoietic cell transplant recipients 4-18 years old and their guardians. Dyads were randomized to first complete dyadic-report (co-SSPedi) or self-report (patients: SSPedi or mini-SSPedi) and proxy-report (guardians: proxy-SSPedi). Dyads then crossed over to the alternate approach. Primary analysis compared total SSPedi scores between randomized groups.
RESULTS
RESULTS
We enrolled 420 dyads that were randomized to co-SSPedi first (n = 213) or proxy-SSPedi and self-report SSPedi first (n = 207). Mean total SSPedi scores (± standard deviation) were: co-SSPedi (9.6 ± 7.1), proxy-SSPedi (9.7 ± 7.5; P = .950 for comparison vs co-SSPedi) and self-report SSPedi (9.7 ± 8.2; P = .981 for comparison vs co-SSPedi). Co-SSPedi scores were significantly different than proxy-SSPedi for feeling disappointed or sad, feeling cranky or angry, feeling tired, mouth sores and changes in taste. Co-SSPedi scores were significantly different than self-report SSPedi scores for problems with thinking or remembering things, feeling tired, mouth sores, tingly or numb hand or feet and diarrhea.
CONCLUSIONS
CONCLUSIONS
Total co-SSPedi scores were not significantly different compared with proxy-report or self-report scores although there were differences in specific symptom scores. If different reporter types are used during clinical implementation, specifying reporter type will be important.The study was registered at clinicaltrials.gov (NCT #05012917).
Identifiants
pubmed: 38048622
pii: 7458447
doi: 10.1093/jnci/djad251
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.