Cohort-based reference values for serum ferritin and transferrin and longitudinal determinants of iron status in European children aged 3 to 15 years.

child health ferritin iron deficiency reference percentiles transferrin

Journal

The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243

Informations de publication

Date de publication:
02 Dec 2023
Historique:
received: 24 07 2023
revised: 10 11 2023
accepted: 01 12 2023
medline: 5 12 2023
pubmed: 5 12 2023
entrez: 4 12 2023
Statut: aheadofprint

Résumé

Reference values of ferritin and transferrin for European children do not exist. We aimed to provide sex-, age- and BMI-specific serum ferritin and transferrin reference percentiles of 3-15 years old children based on cohort data and to investigate determinants of iron status. A total of 3,390 ferritin and 3,416 transferrin measurements from children residing in eight European countries participating in the IDEFICS/I.Family cohort (https://www.isrctn.com/ISRCTN62310987) at baseline (W0) and 6 years later (W3) were used to estimate percentiles using the generalized additive model for location, scale and shape. Associations of serum ferritin and transferrin concentrations with total iron intake, total iron intake additionally adjusted for vitamin C intake, and iron from heme sources were investigated separately with adjustment for sex, age, country of residence, parental education, usual energy intake and BMI z-score in regression models using cross-sectional and longitudinal data. The age-specific ferritin and transferrin 5 Age-, sex- and BMI-specific reference percentiles of serum ferritin and transferrin concentrations based on cohort data are provided for European children aged 3 to 15 years and may be used in clinical practice.

Sections du résumé

BACKGROUND BACKGROUND
Reference values of ferritin and transferrin for European children do not exist.
OBJECTIVE OBJECTIVE
We aimed to provide sex-, age- and BMI-specific serum ferritin and transferrin reference percentiles of 3-15 years old children based on cohort data and to investigate determinants of iron status.
METHODS METHODS
A total of 3,390 ferritin and 3,416 transferrin measurements from children residing in eight European countries participating in the IDEFICS/I.Family cohort (https://www.isrctn.com/ISRCTN62310987) at baseline (W0) and 6 years later (W3) were used to estimate percentiles using the generalized additive model for location, scale and shape. Associations of serum ferritin and transferrin concentrations with total iron intake, total iron intake additionally adjusted for vitamin C intake, and iron from heme sources were investigated separately with adjustment for sex, age, country of residence, parental education, usual energy intake and BMI z-score in regression models using cross-sectional and longitudinal data.
RESULTS RESULTS
The age-specific ferritin and transferrin 5
CONCLUSIONS CONCLUSIONS
Age-, sex- and BMI-specific reference percentiles of serum ferritin and transferrin concentrations based on cohort data are provided for European children aged 3 to 15 years and may be used in clinical practice.

Identifiants

DOI: 10.1016/j.tjnut.2023.12.001 PMID: 38048991
pubmed: 38048991
pii: S0022-3166(23)72783-1
doi: 10.1016/j.tjnut.2023.12.001
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Auteurs

Anna Floegel (A)

Section of Dietetics, Faculty of Agriculture and Food Sciences, Hochschule Neubrandenburg - University of Applied Sciences, 17033 Neubrandenburg, Germany; Leibniz Institute for Prevention Research and Epidemiology - BIPS, 28359 Bremen, Germany.

Timm Intemann (T)

Leibniz Institute for Prevention Research and Epidemiology - BIPS, 28359 Bremen, Germany.

Alfonso Siani (A)

Institute of Food Sciences, National Research Council, 83100 Avellino, Italy.

Luis A Moreno (LA)

GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), 50009 Zaragoza, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Dénes Molnár (D)

Department of Pediatrics, Medical School, University of Pécs, 7623 Pécs, Hungary.

Tomaas Veidebaum (T)

National Institute for Health Development, Estonian Centre of Behavioral and Health Sciences, 11619 Tallinn, Estonia.

Charalambos Hadjigeorgiou (C)

Research and Education Institute of Child Health, 2035 Strovolos, Cyprus.

Stefaan De Henauw (S)

Department of Public Health and Primary Care, Ghent University, 9000 Ghent, Belgium.

Monica Hunsberger (M)

Section for Epidemiology and Social Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.

Gabriele Eiben (G)

Department of Public Health, School of Health Sciences, University of Skövde, Skövde, Sweden.

Wolfgang Ahrens (W)

Leibniz Institute for Prevention Research and Epidemiology - BIPS, 28359 Bremen, Germany; Institute of Statistics, Faculty of Mathematics and Computer Science, University of Bremen, 28359 Bremen, Germany.

Maike Wolters (M)

Leibniz Institute for Prevention Research and Epidemiology - BIPS, 28359 Bremen, Germany. Electronic address: wolters@leibniz-bips.de.
Section of Dietetics, Faculty of Agriculture and Food Sciences, Hochschule Neubrandenburg - University of Applied Sciences, 17033 Neubrandenburg, Germany.

Classifications MeSH