Associatons Between Ageing And Vitamin D Status With Whole-Body Nitric Oxide Production And Markers Of Endothelial Function.
ageing
endothelial function
nitric oxide
pulse wave velocity
vitamin D
Journal
The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243
Informations de publication
Date de publication:
02 Dec 2023
02 Dec 2023
Historique:
received:
17
10
2023
revised:
23
11
2023
accepted:
01
12
2023
medline:
5
12
2023
pubmed:
5
12
2023
entrez:
4
12
2023
Statut:
aheadofprint
Résumé
Ageing and vitamin D deficiency have been associated with reduced nitric oxide (NO) synthesis and impaired endothelial function (EF) but the evidence in humans remains weak. Two independent cross-sectional studies were designed to evaluate the association between age, sex and plasma vitamin D concentrations with physiological and biochemical biomarkers of NO synthesis and EF in young and older healthy participants (Study-1) and in overweight and obese post-menopausal women (Study-2). In Study-1, forty young (20-49years) and older (50-75years) males and females (10 participants per age and sex group) were included. Resting blood pressure and ear-to-finger peripheral pulse wave velocity (PWV) were measured. A stable isotopic method was used to determine whole-body NO production. Plasma 25-hydroxyvitamin D (25(OH)D), nitrate, nitrite, and asymmetric dimethyl-arginine (ADMA) concentrations were determined. In Study-2, eighty older overweight and obese women (age 61.2±6.2years, BMI 29.5±4.4kg/m In Study-1, whole-body NO production was significantly greater in young compared with older participants (0.61±0.30μmol·hr Older age was associated with lower whole-body NO production. Plasma vitamin D concentrations were not associated with NO production or markers of EF but showed a weak, significant correlation with oxidative stress in post-menopausal overweight women.
Sections du résumé
BACKGROUND
BACKGROUND
Ageing and vitamin D deficiency have been associated with reduced nitric oxide (NO) synthesis and impaired endothelial function (EF) but the evidence in humans remains weak.
OBJECTIVES
OBJECTIVE
Two independent cross-sectional studies were designed to evaluate the association between age, sex and plasma vitamin D concentrations with physiological and biochemical biomarkers of NO synthesis and EF in young and older healthy participants (Study-1) and in overweight and obese post-menopausal women (Study-2).
METHODS
METHODS
In Study-1, forty young (20-49years) and older (50-75years) males and females (10 participants per age and sex group) were included. Resting blood pressure and ear-to-finger peripheral pulse wave velocity (PWV) were measured. A stable isotopic method was used to determine whole-body NO production. Plasma 25-hydroxyvitamin D (25(OH)D), nitrate, nitrite, and asymmetric dimethyl-arginine (ADMA) concentrations were determined. In Study-2, eighty older overweight and obese women (age 61.2±6.2years, BMI 29.5±4.4kg/m
RESULTS
RESULTS
In Study-1, whole-body NO production was significantly greater in young compared with older participants (0.61±0.30μmol·hr
CONCLUSIONS
CONCLUSIONS
Older age was associated with lower whole-body NO production. Plasma vitamin D concentrations were not associated with NO production or markers of EF but showed a weak, significant correlation with oxidative stress in post-menopausal overweight women.
Identifiants
pubmed: 38048992
pii: S0022-3166(23)72784-3
doi: 10.1016/j.tjnut.2023.12.002
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. None to declare