Osteoimmunology: Interactions With the Immune System in Spinal Fusion.

Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the osteogenic, osteoconductive, and osteoinductive properties of bone grafts and substitutes and ultimately influences the success of spinal fusion. Macrophages have emerged as important cells for coordinating the immune response following spinal fusion surgery, and macrophage-derived cytokines impact each phase of bone graft healing. This review explores the cellular and molecular immune processes that regulate bone homeostasis and healing during spinal fusion.

Informations de copyright

This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2023 ISASS. To see more or order reprints or permissions, see http://ijssurgery.com.

Déclaration de conflit d'intérêts

Declaration of Conflicting Interests : Stephen Bergin, Carolyn Keeler, Brett Rocos, Michael Guo, Oren Gottfried, Michael Guo, and William Richardson have nothing to disclose. Clifford Crutcher discloses that he is a consultant for Alphatec and Depuy Synthes. Michael Haglund discloses that he received grants from Alphatec Spine and Medtronic, royalties from Alphatec Spine, and consulting fees from Alphatec, Providence, and Nuvasive. Khoi Than discloses that he is a consultant for DePuy Synthes, Nuvasive, Accelus, Bioventus, and Cerapedics and has received honoraria from SI-Bone.