Metabolic tagging of extracellular vesicles and development of enhanced extracellular vesicle based cancer vaccines.

Humans Cancer Vaccines / metabolism Extracellular Vesicles / metabolism Cell Communication Skin Neoplasms / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
05 Dec 2023
Historique:
received: 06 05 2023
accepted: 23 11 2023
medline: 7 12 2023
pubmed: 6 12 2023
entrez: 5 12 2023
Statut: epublish

Résumé

As key mediators of cellular communication, extracellular vesicles (EVs) have been actively explored for diagnostic and therapeutic applications. However, effective methods to functionalize EVs and modulate the interaction between EVs and recipient cells are still lacking. Here we report a facile and universal metabolic tagging technology that can install unique chemical tags (e.g., azido groups) onto EVs. The surface chemical tags enable conjugation of molecules via efficient click chemistry, for the tracking and targeted modulation of EVs. In the context of tumor EV vaccines, we show that the conjugation of toll-like receptor 9 agonists onto EVs enables timely activation of dendritic cells and generation of superior antitumor CD8

Identifiants

DOI: 10.1038/s41467-023-43914-8 PMID: 38052869 PMC: PMC10697976
pubmed: 38052869
doi: 10.1038/s41467-023-43914-8
pii: 10.1038/s41467-023-43914-8
pmc: PMC10697976
doi:

Substances chimiques

Cancer Vaccines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8047

Subventions

Organisme : NCI NIH HHS
ID : R21 CA270872
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA234025
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA274738
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB019944
Pays : United States

Informations de copyright

© 2023. The Author(s).

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Auteurs

Rimsha Bhatta (R)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Joonsu Han (J)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
ORCID: 0000-0002-7794-0661

Yusheng Liu (Y)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Yang Bo (Y)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

David Lee (D)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Jiadiao Zhou (J)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Yueji Wang (Y)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.

Erik Russell Nelson (ER)

Cancer Center at Illinois (CCIL), Urbana, IL, 61801, USA.
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Department of Molecular and Integrative Physiology, University of Illinois at Urbana-, Champaign, IL, USA.
ORCID: 0000-0002-8887-1905

Qian Chen (Q)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
ORCID: 0000-0002-1968-441X

Xiaojia Shelly Zhang (XS)

Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
National Center for Supercomputing Applications, Urbana, IL, 61801, USA.
ORCID: 0000-0003-4878-8637

Wael Hassaneen (W)

Carle College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Carle Foundation Hospital, Urbana, IL, 61801, USA.

Hua Wang (H)

Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. huawang3@illinois.edu.
Cancer Center at Illinois (CCIL), Urbana, IL, 61801, USA. huawang3@illinois.edu.
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. huawang3@illinois.edu.
Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. huawang3@illinois.edu.
Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. huawang3@illinois.edu.
Carle College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. huawang3@illinois.edu.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. huawang3@illinois.edu.
ORCID: 0000-0002-1157-8786

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolic tagging of extracellular vesicles...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins anticancéreux › Metabolic tagging of extracellular vesicles...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Metabolic tagging of extracellular vesicles...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Metabolic tagging of extracellular vesicles...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Metabolic tagging of extracellular vesicles...