Dysregulated wound healing in the pathogenesis of urogynecologic mesh complications.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 Dec 2023
05 Dec 2023
Historique:
received:
28
04
2023
accepted:
26
11
2023
medline:
7
12
2023
pubmed:
6
12
2023
entrez:
5
12
2023
Statut:
epublish
Résumé
To test the hypothesis that dysregulated wound healing is associated with Urogynecologic mesh complications, we collected vaginal cell secretions using vaginal swabs after polypropylene mesh implantation in patients with (N = 39) and without (N = 40) complication. A customized multiplex immunoassay measured markers of inflammation (MCP-1, IGFBP-1, IL-2, IL-10, IL-17, PDGF-BB, bFGF, IL-1b, IL-6, IL-12p70, TNF-α), neuroinflammation (IL-1RA, TGF-β, IL-15, IL-18, IL-3, M-CSF), angiogenesis (VEGF), and matrix proteins (fibronectin, tenasin c, thrombospondin-2, lumican) between groups. Patients with complications were younger, heavier, implanted with mesh longer, and more likely to be ever smokers. A 5 kg/m
Identifiants
pubmed: 38052928
doi: 10.1038/s41598-023-48388-8
pii: 10.1038/s41598-023-48388-8
pmc: PMC10698181
doi:
Substances chimiques
Fibronectins
0
Vascular Endothelial Growth Factor A
0
Thrombospondins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21437Subventions
Organisme : NIH HHS
ID : R21HD099549
Pays : United States
Organisme : NIH HHS
ID : R01 HD083383-01
Pays : United States
Organisme : NIH HHS
ID : NIH/ORWH Building Interdisciplinary Research Careers in Women's Health (BIRCWH) NIH K12HD043441
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD083383
Pays : United States
Organisme : NIH HHS
ID : NIH R01HD108666
Pays : United States
Informations de copyright
© 2023. The Author(s).
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