Metabolites 13,14-Dihydro-15-keto-PGE2 Participates in Bifidobacterium animalis F1-7 to Alleviate Opioid-Induced Constipation by 5-HT Pathway.
13,14-Dihydro-15-keto-PGE2
5-HT pathway
Bifidobacterium animalis F1-7
constipation
metabolites
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
06 Dec 2023
06 Dec 2023
Historique:
revised:
13
07
2023
received:
03
12
2022
medline:
6
12
2023
pubmed:
6
12
2023
entrez:
6
12
2023
Statut:
aheadofprint
Résumé
People suffer from constipation caused by many factors, including constipation (Opioid-Induced Constipation, OIC) during analgesic treatment. Microorganisms may be a potent solution to this problem, but the mechanism is still unclear. Based on models in vivo and in vitro, the potential mechanism involving Bifidobacterium animalis F1-7 (B. animalis F1-7), screened in the previous studies, is explored through non-targeted metabonomics, electrophysiological experiment and molecular level docking. The results showed that B. animalis F1-7 effectively alleviates OIC and promotes the expression of chromogranin A (CGA) and 5-hydroxytryptamine (5-HT). The metabolite 13,14-dihydro-15-keto-PGE2 related to B. animalis F1-7 is found, which has a potential improvement effect on OIC at 20 mg kg BW The results demonstrate that metabolite 13,14-dihydro-15-keto-PGE2 participated in B. animalis F1-7 to alleviate OIC via the 5-HT pathway.
Identifiants
pubmed: 38054625
doi: 10.1002/mnfr.202200846
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200846Subventions
Organisme : National Natural Science Foundation of China
ID : 32202061
Organisme : Natural Science Foundation of Hubei Province of China
ID : 2022CFB763
Organisme : Fundamental Research Funds for the Central Universities
ID : 2662022SPQD001
Organisme : Project of Taishan Industry Leading Talent of Shandong Province
ID : LJNY202101
Organisme : National Key Research and Development Program of China
ID : 2018YFC1604300
Informations de copyright
© 2023 Wiley-VCH GmbH.
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