AAA ATPase protein-protein interactions as therapeutic targets in cancer.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
05 Dec 2023
05 Dec 2023
Historique:
received:
30
06
2023
revised:
30
10
2023
accepted:
09
11
2023
medline:
7
12
2023
pubmed:
7
12
2023
entrez:
6
12
2023
Statut:
aheadofprint
Résumé
AAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic targets because of their role in cancers which rely on increased AAA ATPase activities for maintenance of genomic stability. Two well-characterized members of this family are p97/VCP and RUVBL ATPases where there is a growing understanding of their structure and function, as well as an emerging landscape of selective inhibitors. Here we highlight recent progress in this field, with particular emphasis on structural advances enabled by cryo-electron microscopy (cryo-EM).
Identifiants
pubmed: 38056141
pii: S0955-0674(23)00140-0
doi: 10.1016/j.ceb.2023.102291
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102291Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: S.S. is the founder and CEO of Gandeeva Therapeutics, a drug discovery company based in Vancouver. Remaining authors declare no conflict of interest.