Transcranial direct current stimulation of the right temporoparietal junction facilitates hippocampal spatial learning in Alzheimer's disease and mild cognitive impairment.

Alzheimer’s disease Hippocampal place cells Navigation network Spatial memory Transcranial direct current stimulation

Journal

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ISSN: 1872-8952
Titre abrégé: Clin Neurophysiol
Pays: Netherlands
ID NLM: 100883319

Informations de publication

Date de publication:
15 Nov 2023
Historique:
received: 22 05 2023
revised: 11 10 2023
accepted: 05 11 2023
medline: 7 12 2023
pubmed: 7 12 2023
entrez: 6 12 2023
Statut: aheadofprint

Résumé

Spatial memory deficits are an early symptom in Alzheimer's disease (AD), reflecting the neurodegenerative processes in the neuronal navigation network such as in hippocampal and parietal cortical areas. As no effective treatment options are available, neuromodulatory interventions are increasingly evaluated. Against this backdrop, we investigated the neuromodulatory effect of anodal transcranial direct current stimulation (tDCS) on hippocampal place learning in patients with AD or mild cognitive impairment (MCI). In this randomized, double-blind, sham-controlled study with a cross-over design anodal tDCS of the right temporoparietal junction (2 mA for 20 min) was applied to 20 patients diagnosed with AD or MCI and in 22 healthy controls while they performed a virtual navigation paradigm testing hippocampal place learning. We show an improved recall performance of hippocampal place learning after anodal tDCS in the patient group compared to sham stimulation but not in the control group. These results suggest that tDCS can facilitate spatial memory consolidation via stimulating the parietal-hippocampal navigation network in AD and MCI patients. Our findings suggest that tDCS of the temporoparietal junction may restore spatial navigation and memory deficits in patients with AD and MCI.

Identifiants

DOI: 10.1016/j.clinph.2023.11.003 PMID: 38056370
pubmed: 38056370
pii: S1388-2457(23)00771-X
doi: 10.1016/j.clinph.2023.11.003
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

48-60

Informations de copyright

Copyright © 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Auteurs

S Philippen (S)

Dept. of Neurology, Memory Disorder and Plasticity Group, University Hospital Schleswig-Holstein, Kiel, Germany.

A Hanert (A)

Dept. of Neurology, Memory Disorder and Plasticity Group, University Hospital Schleswig-Holstein, Kiel, Germany.

R Schönfeld (R)

Psychology Department, Halle University, Germany.

O Granert (O)

Dept. of Neurology, Memory Disorder and Plasticity Group, University Hospital Schleswig-Holstein, Kiel, Germany.

R Yilmaz (R)

Dept. of Neurology, University of Ankara, Medical School, Ankara, Turkey.

U Jensen-Kondering (U)

Dept. of Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel, Germany; Dept. of Neuroradiology, University Hospital Schleswig-Holstein, Lübeck, Germany.

M Splittgerber (M)

Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Germany.

V Moliadze (V)

Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Germany.

M Siniatchkin (M)

Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Germany; Clinic for Child and Adolescent Psychiatry and Psychotherapy, Medical Center Bethel, University Clinics OWL, Bielefeld University, Germany.

D Berg (D)

Dept. of Neurology, Memory Disorder and Plasticity Group, University Hospital Schleswig-Holstein, Kiel, Germany.

T Bartsch (T)

Dept. of Neurology, Memory Disorder and Plasticity Group, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address: t.bartsch@neurologie.uni-kiel.de.

Classifications MeSH